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Clinica Chimica Acta:血清白介素-33作为重型颅脑损伤预后指标的有效性如何?

2019-11-23 gladiator MedSci原创

最近,白细胞介素-33被作为脑损伤的生物标志物。本研究检测了血清白细胞介素-33浓度是否与创伤性脑损伤(TBI)后的炎症、严重程度和预后相关。

最近,白细胞介素-33被作为脑损伤的生物标志物。本研究检测了血清白细胞介素-33浓度是否与创伤性脑损伤(TBI)后的炎症、严重程度和预后相关。

研究人员对 102健康对照组和102年的严重创伤性脑损伤的患者的血清浓度interlerukin-33以及102年严重的创伤性脑损伤的患者的3种炎症生物标志物的血清浓度(白细胞介素- 6、肿瘤坏死因子-α和c反应蛋白)7个特异性蛋白质(髓磷脂碱性蛋白、胶质纤丝的星形胶质细胞蛋白质、S100B、特异性神经元烯醇酶、磷酸化轴突神经丝亚基H,τ和泛素羧基末端水解酶L1)。记录的不良预后变量包括急性肺损伤、急性创伤性凝血障碍、进行性出血损伤、创伤后脑梗死和6个月死亡率以及不良预后(格拉斯哥评分1-3)

研究发现,于对照组相比,病例组的interlerukin-33浓度中位数(692pg / mL)显著提高。Interlerukin-33浓度>> 692692pg / mL成为独立的预后指标,其鉴别能力超过了上述炎症生物标志物的浓度,且在GCS评分和上述细胞特异性蛋白浓度范围内。

研究表明,血清白细胞介素-33浓度升高可以反映TBI后的炎症、严重程度和较差的预后。

原始出处:

Zu-Yong ZhangJun LiUsefulness of serum interleukin-33 as a prognostic marker of severe traumatic brain injury

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    2020-03-11 windight
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