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Cell Rep:惊人发现!维生素B3有望治疗帕金森!

2018-06-11 Zoe 转化医学网

导 读 颤颤巍巍的老人于我们的生活中随处可见,他们可能罹患了帕金森氏症。除了手抖之外,帕金森患者同时还伴有肌肉僵硬,动作迟缓等症状,无法彻底治愈是他们内心的隐痛。有关数据统计,德国约有22万人受到帕金森病的影响,而我国65岁以上人群患病率大约是1.7%,数值着实令人心惊!


导  读

颤颤巍巍的老人于我们的生活中随处可见,他们可能罹患了帕金森氏症。除了手抖之外,帕金森患者同时还伴有肌肉僵硬,动作迟缓等症状,无法彻底治愈是他们内心的隐痛。有关数据统计,德国约有22万人受到帕金森病的影响,而我国65岁以上人群患病率大约是1.7%,数值着实令人心惊!

Michela Deleidi博士领导的研究小组近日有了新的发现:维生素B3的一种形式——烟酰胺核糖体可以刺激神经细胞,并保护它们免于走上无可避免的死亡之途,这可能会为帕金森提供一种新型治疗方案,也为广大患者带来希望!

究竟是什么左右了帕金森病的发展?这个问题困扰了研究者多年!

根据他们以往的认知,帕金森病最主要的病理改变是中脑黑质多巴胺能神经元的变性死亡。但近日他们对此有了新的认识:

在神经元变性死亡的同时,这些神经细胞中的线粒体也会随之受到损害。

线粒体是细胞的能量来源和小型动力装置。当它们受到损害时,细胞便会死亡。

是否是这种受损的线粒体导致了帕金森氏症呢?

为了寻求答案,研究人员与国际同行合作,进行了一项针对性实验。该研究于近日以“The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson’s Disease”为题发表在《Cell Reports》上。

研究者从帕金森氏症患者身上采集了皮肤细胞样本。他们通过刺激这些细胞来将它们转化为干细胞,然后这些干细胞会发展成为神经细胞。这些细胞存在GBA基因缺陷—帕金森病最常见的风险基因。如同真正的神经细胞一样,它们的线粒体受到了损害。

维生素B3促进新的线粒体生成

随后,研究人员给这些细胞添加了烟酰胺核糖体,它既是维生素B3的一种形式,也是辅酶的初级阶段。这导致了细胞内辅酶NAD浓度的升高。结果显示:

新的线粒体形成,能量产生增加。

维生素B3减少神经细胞死亡

为了观察维生素在生物体内的作用,研究人员进一步研究了GBA基因缺陷果蝇。与帕金森氏症患者一样,果蝇的多巴胺能神经元逐渐消失,随着年龄的增长,果蝇在行走和攀爬上越来越困难。

Deleidi和她的同事将果蝇分为两组。一组接受富含维生素的饲料,另一组则不含维生素。他们发现:

在接受治疗的果蝇中,很少有神经细胞死亡。此外,它们的移动时间更长。

研究者表示:线粒体的缺失在帕金森病的发展中起着至关重要的作用,而烟酰胺核糖体可能会成为帕金森治疗的新希望。

虽然目前已有相关研究表明,烟酰胺核糖体能够促进健康人群的能量代谢。但是还需要进一步的研究来确定这种维生素是否对帕金森患者有真正的帮助。但这项研究无疑让失意的帕金森患者重燃希望!

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    2019-04-03 维他命
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    2018-06-12 1e1f732cm83(暂无匿称)

    不错

    0

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    2018-06-12 kafei

    学习了谢谢分享

    0

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    2018-06-11 329523732

    不错

    0

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    2018-06-11 wqkm

    ^_^^_^^_^

    0

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