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NEJM:Bimekizumab vs 阿达木单抗治疗中重度斑块性银屑病

2021-04-24 MedSci原创 MedSci原创

Bimekizumab对中重度斑块性银屑病的治疗效果由于阿达木单抗,但腹泻及感染风险增加

促炎症细胞因子白细胞介素12和肿瘤坏死因子(TNF)在银屑病的发病机制中发挥作用,而白介素17和白介素23也参与了银屑病的发病过程,但目前TNF抑制剂仍然是银屑病的主要治疗方法,阿达木单抗是其中的代表药物。Bimekizumab是一种新型人源化单克隆IgG1抗体,能强效、选择性地中和白介素17A和白介素17F。近日研究人员比较了 Bimekizumab与阿达木单抗对中重度斑块性银屑病的治疗效果。

中重度斑块性银屑病患者随机接受每4周320mg Bimekizumab治疗持续56周、每4周320mg Bimekizumab治疗持续16周,随后调整为每8周320mg Bimekizumab治疗持续至56周或每2周40mg阿达木单抗治疗持续24周,随后每4周接受320mg Bimekizumab治疗持续至56周。研究的主要终点为16周时,PASI90响应(银屑病面积和严重程度指数至少改善90%)和IGA0/1缓解(皮损完全清除或几乎清除),非劣性边界为10%。

478名患者参与研究,每4周Bimekizumab治疗组158人,每4周随后8周Bimekizumab治疗组161人,阿达木单抗治疗组159人。患者平均年龄44.9岁,基线平均PASI得分为19.8。16周时,2个剂量Bimekizumab组86.2%的患者实现PASI 90响应,而阿达木单抗组仅为47.2%,差异为39.3%。2个剂量Bimekizumab组85.3%的患者实现IGA 0/1缓解,而阿达木单抗组仅为57.2%,差异为28.2%。Bimekizumab治疗组最常见的不良事件为呼吸道感染、轻微口腔念珠菌病、高血压和腹泻。

研究认为,Bimekizumab对中重度斑块性银屑病的治疗效果由于阿达木单抗,但腹泻及感染风险增加

原始出处:

Richard B. Warren et al. Bimekizumab versus Adalimumab in Plaque Psoriasis. N Engl J Med, April 23, 2021.

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    2021-05-20 snf701207
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    2021-05-20 naiwu77
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    2021-06-06 zhu333

    未来可期

    0

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    2021-05-11 SR~young海东

    医学发展,科学进步

    0

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  6. [GetPortalCommentsPageByObjectIdResponse(id=1912589, encodeId=dc2519125897b, content=<a href='/topic/show?id=4de7112046c' target=_blank style='color:#2F92EE;'>#mAb#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11204, encryptionId=4de7112046c, topicName=mAb)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Thu May 20 10:19:23 CST 2021, time=2021-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1943927, encodeId=2a49194392e98, content=<a href='/topic/show?id=d2af1152597' target=_blank style='color:#2F92EE;'>#MEK#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11525, encryptionId=d2af1152597, topicName=MEK)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b0e350, createdName=naiwu77, createdTime=Thu May 20 01:19:23 CST 2021, time=2021-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=971242, encodeId=374b9e124252, content=未来可期, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd7e110192, createdName=zhu333, createdTime=Sun Jun 06 07:50:50 CST 2021, time=2021-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=964740, encodeId=203d964e404d, content=医学发展,科学进步, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210313/9df56058b3964a8cac82563f95f0389d/c1b478592e8e4463bef44d32712e98fd.jpg, createdBy=ea905324251, createdName=SR~young海东, createdTime=Tue May 11 22:06:00 CST 2021, time=2021-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1330177, encodeId=1fe813301e7a1, content=<a href='/topic/show?id=a91c5e92328' target=_blank style='color:#2F92EE;'>#斑块#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57923, encryptionId=a91c5e92328, topicName=斑块)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/4E6244DB7C1860858424437821E08291/100, createdBy=a6a52500039, createdName=ms3994565386320060, createdTime=Mon Apr 26 02:19:23 CST 2021, time=2021-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1615653, encodeId=4ae31615653fb, content=<a href='/topic/show?id=3eb39e945b2' target=_blank style='color:#2F92EE;'>#阿达木#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97945, encryptionId=3eb39e945b2, topicName=阿达木)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3dba19658752, createdName=1179102698_36768932, createdTime=Mon Apr 26 02:19:23 CST 2021, time=2021-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=960063, encodeId=f7289600631a, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sat Apr 24 17:03:10 CST 2021, time=2021-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035631, encodeId=540010356313c, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Sat Apr 24 14:19:23 CST 2021, time=2021-04-24, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1912589, encodeId=dc2519125897b, content=<a href='/topic/show?id=4de7112046c' target=_blank style='color:#2F92EE;'>#mAb#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11204, encryptionId=4de7112046c, topicName=mAb)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Thu May 20 10:19:23 CST 2021, time=2021-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1943927, encodeId=2a49194392e98, content=<a href='/topic/show?id=d2af1152597' target=_blank style='color:#2F92EE;'>#MEK#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11525, encryptionId=d2af1152597, topicName=MEK)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b0e350, createdName=naiwu77, createdTime=Thu May 20 01:19:23 CST 2021, time=2021-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=971242, encodeId=374b9e124252, content=未来可期, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd7e110192, createdName=zhu333, createdTime=Sun Jun 06 07:50:50 CST 2021, time=2021-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=964740, encodeId=203d964e404d, content=医学发展,科学进步, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210313/9df56058b3964a8cac82563f95f0389d/c1b478592e8e4463bef44d32712e98fd.jpg, createdBy=ea905324251, createdName=SR~young海东, createdTime=Tue May 11 22:06:00 CST 2021, time=2021-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1330177, encodeId=1fe813301e7a1, content=<a href='/topic/show?id=a91c5e92328' target=_blank style='color:#2F92EE;'>#斑块#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57923, encryptionId=a91c5e92328, topicName=斑块)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/4E6244DB7C1860858424437821E08291/100, createdBy=a6a52500039, createdName=ms3994565386320060, createdTime=Mon Apr 26 02:19:23 CST 2021, time=2021-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1615653, encodeId=4ae31615653fb, content=<a href='/topic/show?id=3eb39e945b2' target=_blank style='color:#2F92EE;'>#阿达木#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97945, encryptionId=3eb39e945b2, topicName=阿达木)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3dba19658752, createdName=1179102698_36768932, createdTime=Mon Apr 26 02:19:23 CST 2021, time=2021-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=960063, encodeId=f7289600631a, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sat Apr 24 17:03:10 CST 2021, time=2021-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035631, encodeId=540010356313c, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Sat Apr 24 14:19:23 CST 2021, time=2021-04-24, status=1, ipAttribution=)]
    2021-04-24 jyzxjiangqin

    好文章!

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1912589, encodeId=dc2519125897b, content=<a href='/topic/show?id=4de7112046c' target=_blank style='color:#2F92EE;'>#mAb#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11204, encryptionId=4de7112046c, topicName=mAb)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Thu May 20 10:19:23 CST 2021, time=2021-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1943927, encodeId=2a49194392e98, content=<a href='/topic/show?id=d2af1152597' target=_blank style='color:#2F92EE;'>#MEK#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11525, encryptionId=d2af1152597, topicName=MEK)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b0e350, createdName=naiwu77, createdTime=Thu May 20 01:19:23 CST 2021, time=2021-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=971242, encodeId=374b9e124252, content=未来可期, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd7e110192, createdName=zhu333, createdTime=Sun Jun 06 07:50:50 CST 2021, time=2021-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=964740, encodeId=203d964e404d, content=医学发展,科学进步, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210313/9df56058b3964a8cac82563f95f0389d/c1b478592e8e4463bef44d32712e98fd.jpg, createdBy=ea905324251, createdName=SR~young海东, createdTime=Tue May 11 22:06:00 CST 2021, time=2021-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1330177, encodeId=1fe813301e7a1, content=<a href='/topic/show?id=a91c5e92328' target=_blank style='color:#2F92EE;'>#斑块#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57923, encryptionId=a91c5e92328, topicName=斑块)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/4E6244DB7C1860858424437821E08291/100, createdBy=a6a52500039, createdName=ms3994565386320060, createdTime=Mon Apr 26 02:19:23 CST 2021, time=2021-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1615653, encodeId=4ae31615653fb, content=<a href='/topic/show?id=3eb39e945b2' target=_blank style='color:#2F92EE;'>#阿达木#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97945, encryptionId=3eb39e945b2, topicName=阿达木)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3dba19658752, createdName=1179102698_36768932, createdTime=Mon Apr 26 02:19:23 CST 2021, time=2021-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=960063, encodeId=f7289600631a, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sat Apr 24 17:03:10 CST 2021, time=2021-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035631, encodeId=540010356313c, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Sat Apr 24 14:19:23 CST 2021, time=2021-04-24, status=1, ipAttribution=)]
    2021-04-24 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

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