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Braz Oral Res:白千层或可用于口腔抗菌,防治龋齿和牙周炎

2020-11-12 MedSci原创 MedSci原创

实验室证据已经证明了白千层(MEL)对口腔微生物具有抗菌作用。本项随机、双盲、交叉临床试验,旨在比较MEL纳米颗粒与0.12%葡萄糖酸洗必泰(CHX)对无生物膜(BF)和生物膜覆盖(BC)表面的抗生物

实验室证据已经证明了白千层(MEL)对口腔微生物具有抗菌作用。本项随机、双盲、交叉临床试验,旨在比较MEL纳米颗粒与0.12%葡萄糖酸洗必泰(CHX)对无生物膜(BF)和生物膜覆盖(BC)表面的抗生物膜和抗炎作用,研究结果已在线发表于Braz Oral Res
在每个实验期之前,参与者在72小时内避免一切口腔卫生行为。将60名参与者分组随机进行两个象限中的一个象限(Q1-Q3或Q2-Q4)的专业预防,并用MEL或CHX冲洗4天。评估了Quigley & Hein斑块指数(QHPI)、牙龈皱襞液(GCF)量和参与者的认知。
结果,CHX显示BF(2.65 ± 0.34 vs. 3.34 ± 0.33,p <0.05)和BC表面(2.84 ± 0.37 vs. 3.37 ± 0.33,p <0.05)的平均QHPI显著降低。组内比较结果显示,所有组的GCF均有减少,仅BF表面的CHX有显著差异(P <0.05)。组间比较显示无显著差异(p > 0.05)。基于个体感知,CHX具有更好的口感和生物膜控制,但导致口感变化较大。尽管如此,MEL表现出与CHX相似的抗炎作用。
但是仍需要进一步的临床试验,测试不同的方案、浓度和随访期,以确定其临床应用。
 
原始出处:
 
Maísa Casarin, Josiele Pazinatto, et al., Anti-biofilm and anti-inflammatory effect of a herbal nanoparticle mouthwash: a randomized crossover trial. Braz Oral Res. 2019 Dec 20;33:e062. doi: 10.1590/1807-3107bor-2019.vol33.0062. 
 

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    2021-01-22 小几洁
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    2020-12-01 370013075_39710255

    谢谢您的分享

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