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Neurology:登革热病毒感染引起的神经系统并发症

2014-11-13 功过不相抵 丁香园

近期,Neurology杂志刊登了一篇研究报道,来自印度乔治国王医科大学的Verma科研团队进行了一项研究,旨在评估登革热病毒感染累及中枢和周围神经系统的发生率、临床表现、预测因子和预后等情况。 为确定神经系统并发症的范畴,本试验采用基于医院的前瞻性队列研究,包括实验室诊断的登革热病毒感染患者,随访3个月。我们同时也分析临床和实验室数据,以评估神经系统受累的预测因子。 本试验共纳入

近期,Neurology杂志刊登了一篇研究报道,来自印度乔治国王医科大学的Verma科研团队进行了一项研究,旨在评估登革热病毒感染累及中枢和周围神经系统的发生率、临床表现、预测因子和预后等情况。

为确定神经系统并发症的范畴,本试验采用基于医院的前瞻性队列研究,包括实验室诊断的登革热病毒感染患者,随访3个月。我们同时也分析临床和实验室数据,以评估神经系统受累的预测因子。

本试验共纳入486例登革热病毒感染患者,其中有2例随访失败,45例出现神经系统并发症。在这45例患者中,28例为中枢神经系统并发症,17例为周围神经系统并发症,由此也可得出神经系统并发症的发生率为9.26%。

实验结果还显示,中枢神经系统并发症重要的预测因子有高热(p = 0.012),红细胞压积高(p = 0.009),血小板减少(p = 0.021)和肝功能异常(p < 0.001)。周围神经系统并发症重要的预测因子有高热(p = 0.031),皮疹 (p = 0.002)和红细胞压积高(p < 0.001)。死亡率为4.5%,其余患者均痊愈。

之前有报道过,登革热神经系统并发症日益广泛且高发。临床与实验室数据,如高热、皮疹、红细胞压积高、血小板减少,以及肝功能异常均是神经系统并发症的独立预测因子。

原始出处:

Ritesh Sahu, MD, Rajesh Verma, DM, DNB, Amita Jain, MD, Ravindra K. Garg, DM, Maneesh K. Singh, DM, Hardeep S. Malhotra, DM, Praveen K. Sharma, DM and Anit Parihar, MD.Neurologic complications in dengue virus infection.Neurology

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    2015-06-18 yinhl1978
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    2015-01-08 丁鹏鹏
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