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Immunity:中科大揭示Omega-3脂肪酸抗炎机制

2013-07-24 koo bio360

ω−3 脂肪酸(Omega-3 fatty acids)又称 n−3 脂肪酸,是一类不饱和脂肪酸,不仅对智力发育非常关键,临床和动物实验显示其对多种炎症相关疾病也具有潜在治疗和预防效果,但其抗炎机制并不清楚。 现在,中国科学技术大学生命科学学院周荣斌、江维和田志刚等人与瑞士洛桑大学(UNIL)的研究人员合作,揭示了 Omega-3(ω-3)脂肪酸抑制炎症和缓解 2 型糖尿病的新机制。相关研究论文

ω−3 脂肪酸(Omega-3 fatty acids)又称 n−3 脂肪酸,是一类不饱和脂肪酸,不仅对智力发育非常关键,临床和动物实验显示其对多种炎症相关疾病也具有潜在治疗和预防效果,但其抗炎机制并不清楚。

现在,中国科学技术大学生命科学学院周荣斌、江维和田志刚等人与瑞士洛桑大学(UNIL)的研究人员合作,揭示了 Omega-3(ω-3)脂肪酸抑制炎症和缓解 2 型糖尿病的新机制。相关研究论文刊登在了近期出版的《免疫》(Immunity)杂志上。

炎症小体是一种由细胞浆内天然免疫识别受体参与组装的多蛋白复合物,能够介导 IL-1 等多种炎症介质的产生,对炎症反应的发生至关重要,并参与肿瘤、神经退行性疾病、代谢性疾病等多种人类炎症相关重大疾病的发生发展。

在这项最新研究中,科研人员发现 Omega-3 脂肪酸能够抑制NLRP3炎症小体的活化,减少炎症关键因子 IL-1b 的分泌。此前的研究发现,NLRP3 炎症小体在高脂食物诱导的 2 型糖尿病发生过程中起到重要作用。此次研究人员进一步利用动物实验,发现 Omega-3 脂肪酸可以通过抑制 NLRP3 炎症小体相关炎症,从而缓解高脂食物诱发的Ⅱ型糖尿病。

研究人员表示,NLRP3 炎症小体可能成为对 2 型糖尿病进行干预的潜在靶标,从而为设计 2 型糖尿病药物提供新思路。

Yan Y, Jiang W, Spinetti T, Tardivel A, Castillo R, Bourquin C, Guarda G, Tian Z, Tschopp J, Zhou R.Omega-3 Fatty Acids Prevent Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome Activation.Immunity. 2013 Jun 27;38(6):1154-63. doi: 10.1016/j.immuni.2013.05.015.PMID:23809162

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Omega-3脂肪酸与前列腺癌风险增高有关(SELECT研究)

   Fred Hutchinson癌症研究中心的第二大前瞻性实验证明,高血药浓度的Omega-3脂肪酸与前列腺癌患病风险增加有关。  研究结果发表在7月11日在线的《美国国家癌症研究所杂志》上,最新发现表明高血药浓度EPA、DPA和DHA——三种抗炎药物以及来源于脂肪鱼和鱼油补充剂有关新城代谢脂肪酸——与71%高分化前列腺癌的增加有关。这项研究同时发现44%低分化前列腺癌的升

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