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Stroke:脑出血前的认知障碍与脑淀粉样血管病相关!

2017-12-16 xing.T MedSci原创

由此可见,经磁共振成像标记确定的CAA与症状性ICH前认知功能下降有关。这提供了证据表明CAA中的小血管破裂除了ICH直接导致的脑损伤外,还对认知功能障碍有独立的作用。

虽然脑淀粉样血管病(CAA)和认知障碍之间的关联越来越受到认可,目前尚不清楚这是否是因为复发性脑出血(ICH)事件、脑小血管损伤引起的破裂或两者均参与的影响。近日,卒中领域权威杂志Stroke上发表了一篇研究文章,研究人员评估了ICH前认知障碍是否与磁共振成像上的CAA影像学特征有关。

研究人员对166例脑影像学确诊的ICH患者进行了前瞻性多中心观察性研究。利用老年人认知功能下降知情者问卷(IQCODE)来确定认知功能障碍。通过训练有素的观察员根据指南共识来评估包括CAA在内的脑小血管疾病的磁共振成像标记。

ICH前认知障碍的患病率为24.7%(n=41),在调整后的分析中,ICH前认知障碍与符合修改后的波士顿CAA标准(比值比为4.01;95%可信区间为1.53-10.51;P=0.005)和较高的复合CAA评分(每增加一点的比值比为1.42;95%可信区间为1.03-1.97;P=0.033)相关。研究人员还发现ICH前的认知能力下降与皮质表面铁沉积、严格脑叶微出血以及脑叶出血位置之间存在独立相关性,但与其他神经影像学标志或复合小血管疾病评分无关。

由此可见,经磁共振成像标记确定的CAA与症状性ICH前认知功能下降有关。这提供了证据表明CAA中的小血管破裂除了ICH直接导致的脑损伤外,还对认知功能障碍有独立的作用。

原始出处:

Gargi Banerjee,et al. Cognitive Impairment Before Intracerebral Hemorrhage Is Associated With Cerebral Amyloid Angiopathy.Stroke. 2017. https://doi.org/10.1161/STROKEAHA.117.019409

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    2018-06-02 飞雁出发

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    2017-12-16 明天会更好!

    学习了.学习了.

    0

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