Baidu
map

JACC:综述:抗血小板药治疗和预防冠状动脉粥样硬化

2017-11-03 吴刚 环球医学

2017年10月,意大利、葡萄牙和英国等国科学家在《J Am Coll Cardiol》发表了抗血小板药治疗和预防冠状动脉粥样硬化的综述

2017年10月,意大利、葡萄牙和英国等国科学家在《J Am Coll Cardiol》发表了抗血小板药治疗和预防冠状动脉粥样硬化的综述。

抗血小板药物是急性缺血综合征(冠脉和脑血管管理预防复发的抗血栓治疗的一线用药。由于抗血小板药与其他预防策略联合时,其潜在获益和风险的平衡存在不确定性,因此抗血小板药在动脉粥样硬化血栓形成一级预防中的作用仍有争议。本综述的目的为,综述抗血小板药的有效性和安全性证据,基于合并症和/或干预措施,为心血管医师提供更新的工具,帮助他们为不同临床表现的冠状动脉血栓形成患者选择最合适的抗血小板策略。

本综述对于不同类别抗血小板药物的临床药理学及作用靶点等进行了详细综述,对抗血小板治疗单药预防的一级预防和二级预防的现状、未来的挑战进行了描述。同时,对抗血小板联合治疗的不同组合方案,如阿司匹林和氯吡格雷、阿司匹林和替格瑞洛、以替格瑞洛为基础的方案以及其他联合方案进行综述。此外,还对出血风险的预测、特殊人群用药监测、停用抗血小板治疗和桥接治疗的不同情况进行了描述和分析。

原始出处:

Patrono C,et al.,Antiplatelet Agents for the Treatment and Prevention of Coronary Atherothrombosis.J Am Coll Cardiol. 2017 Oct 3;70(14):1760-1776.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1222969, encodeId=21fd1222969ed, content=<a href='/topic/show?id=98ba30898c7' target=_blank style='color:#2F92EE;'>#冠状动脉粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30898, encryptionId=98ba30898c7, topicName=冠状动脉粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=清风徐来2022, createdTime=Sat May 28 11:39:10 CST 2022, time=2022-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1944500, encodeId=0e2419445005d, content=<a href='/topic/show?id=411de6300ad' target=_blank style='color:#2F92EE;'>#粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76300, encryptionId=411de6300ad, topicName=粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b30d401, createdName=huangshifeng, createdTime=Thu Mar 01 09:22:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1853837, encodeId=f863185383e34, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Thu Aug 30 05:22:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2032552, encodeId=4106203255222, content=<a href='/topic/show?id=e00855e5387' target=_blank style='color:#2F92EE;'>#抗血小板药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55753, encryptionId=e00855e5387, topicName=抗血小板药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, createdName=shizhenshan, createdTime=Thu Mar 29 11:22:00 CST 2018, time=2018-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325593, encodeId=d99013255937c, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Sun Nov 05 05:22:00 CST 2017, time=2017-11-05, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1222969, encodeId=21fd1222969ed, content=<a href='/topic/show?id=98ba30898c7' target=_blank style='color:#2F92EE;'>#冠状动脉粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30898, encryptionId=98ba30898c7, topicName=冠状动脉粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=清风徐来2022, createdTime=Sat May 28 11:39:10 CST 2022, time=2022-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1944500, encodeId=0e2419445005d, content=<a href='/topic/show?id=411de6300ad' target=_blank style='color:#2F92EE;'>#粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76300, encryptionId=411de6300ad, topicName=粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b30d401, createdName=huangshifeng, createdTime=Thu Mar 01 09:22:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1853837, encodeId=f863185383e34, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Thu Aug 30 05:22:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2032552, encodeId=4106203255222, content=<a href='/topic/show?id=e00855e5387' target=_blank style='color:#2F92EE;'>#抗血小板药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55753, encryptionId=e00855e5387, topicName=抗血小板药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, createdName=shizhenshan, createdTime=Thu Mar 29 11:22:00 CST 2018, time=2018-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325593, encodeId=d99013255937c, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Sun Nov 05 05:22:00 CST 2017, time=2017-11-05, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1222969, encodeId=21fd1222969ed, content=<a href='/topic/show?id=98ba30898c7' target=_blank style='color:#2F92EE;'>#冠状动脉粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30898, encryptionId=98ba30898c7, topicName=冠状动脉粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=清风徐来2022, createdTime=Sat May 28 11:39:10 CST 2022, time=2022-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1944500, encodeId=0e2419445005d, content=<a href='/topic/show?id=411de6300ad' target=_blank style='color:#2F92EE;'>#粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76300, encryptionId=411de6300ad, topicName=粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b30d401, createdName=huangshifeng, createdTime=Thu Mar 01 09:22:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1853837, encodeId=f863185383e34, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Thu Aug 30 05:22:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2032552, encodeId=4106203255222, content=<a href='/topic/show?id=e00855e5387' target=_blank style='color:#2F92EE;'>#抗血小板药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55753, encryptionId=e00855e5387, topicName=抗血小板药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, createdName=shizhenshan, createdTime=Thu Mar 29 11:22:00 CST 2018, time=2018-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325593, encodeId=d99013255937c, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Sun Nov 05 05:22:00 CST 2017, time=2017-11-05, status=1, ipAttribution=)]
    2018-08-30 hbwxf
  4. [GetPortalCommentsPageByObjectIdResponse(id=1222969, encodeId=21fd1222969ed, content=<a href='/topic/show?id=98ba30898c7' target=_blank style='color:#2F92EE;'>#冠状动脉粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30898, encryptionId=98ba30898c7, topicName=冠状动脉粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=清风徐来2022, createdTime=Sat May 28 11:39:10 CST 2022, time=2022-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1944500, encodeId=0e2419445005d, content=<a href='/topic/show?id=411de6300ad' target=_blank style='color:#2F92EE;'>#粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76300, encryptionId=411de6300ad, topicName=粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b30d401, createdName=huangshifeng, createdTime=Thu Mar 01 09:22:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1853837, encodeId=f863185383e34, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Thu Aug 30 05:22:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2032552, encodeId=4106203255222, content=<a href='/topic/show?id=e00855e5387' target=_blank style='color:#2F92EE;'>#抗血小板药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55753, encryptionId=e00855e5387, topicName=抗血小板药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, createdName=shizhenshan, createdTime=Thu Mar 29 11:22:00 CST 2018, time=2018-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325593, encodeId=d99013255937c, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Sun Nov 05 05:22:00 CST 2017, time=2017-11-05, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1222969, encodeId=21fd1222969ed, content=<a href='/topic/show?id=98ba30898c7' target=_blank style='color:#2F92EE;'>#冠状动脉粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30898, encryptionId=98ba30898c7, topicName=冠状动脉粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=清风徐来2022, createdTime=Sat May 28 11:39:10 CST 2022, time=2022-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1944500, encodeId=0e2419445005d, content=<a href='/topic/show?id=411de6300ad' target=_blank style='color:#2F92EE;'>#粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76300, encryptionId=411de6300ad, topicName=粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b30d401, createdName=huangshifeng, createdTime=Thu Mar 01 09:22:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1853837, encodeId=f863185383e34, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Thu Aug 30 05:22:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2032552, encodeId=4106203255222, content=<a href='/topic/show?id=e00855e5387' target=_blank style='color:#2F92EE;'>#抗血小板药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55753, encryptionId=e00855e5387, topicName=抗血小板药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, createdName=shizhenshan, createdTime=Thu Mar 29 11:22:00 CST 2018, time=2018-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325593, encodeId=d99013255937c, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Sun Nov 05 05:22:00 CST 2017, time=2017-11-05, status=1, ipAttribution=)]

相关资讯

Pharmacotherapy:ACS:三种口服抗血小板药物治疗的临床结局

口服抗血小板治疗是急性冠脉综合征(ACS)治疗的基石,随着新型口服抗血小板逐步在临床应用,为依据ACS患者的不同类型进行合理的治疗带来了更多选择。2017年8月,发表在《Pharmacotherapy.》的一项研究比较了ACS患者口服抗血小板药物氯吡格雷、普拉格雷和替格瑞洛的临床结局。

NEJM:卵圆孔未闭封堵术vs抗血小板,抗血小板vs抗凝

病例对照研究显示卵圆孔未闭(PFO)与隐源性卒中有关,特别是年龄小于55岁和合并房间隔动脉瘤或大量右向左分流的患者。在这些患者中,关闭PFO预防卒中复发的疗效尚不清楚。闭合卵圆孔理论上应该能够降低卒中复发风险,但是几项随机对照试验并没有发现PFO闭合优于抗栓治疗。

Cardiovasc Ther:抗血小板治疗模式的临床结局是否受性别影响?

抗血小板治疗模式的结局是否受到性别影响?2017年8月,发表在《Cardiovasc Ther.》的一项前瞻性、观察性、多中心队列研究调查了接受氯吡格雷、普拉格雷或替卡格雷治疗的经历经皮冠状动脉介入治疗(PCI)的急性冠脉综合征(ACS)患者临床结局的性别差异。

双联抗血小板到底要吃多久?指南告诉你

借着2017年ESC抗血小板治疗指南公布的契机,我们一起学习下,双联抗血小板到底要吃多久?

NEJM:卵圆孔封闭联合抗血小板治疗可以有效抑制中风复发

研究认为对于卵圆孔未闭中风患者,接受卵圆孔封闭联合抗血小板治疗可以有效的抑制中风复发

Circulation刊登复旦大学研究:揭示糖尿病人心血管风险升高原因

近期,Circulation杂志刊登了复旦大学丁忠仁、胡亮等的研究成果,他们发现,糖尿病患者体内血小板P2Y12受体呈高表达、异常激活的现象。糖尿病患者的血小板P2Y12受体水平是一般健康人的4倍。

Baidu
map
Baidu
map
Baidu
map