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SCI REP:血清铁调素可能是一种新的尿毒症毒素,可能与促红细胞生成素抵抗有关!

2017-06-26 xing.T MedSci原创

这些研究结果表明血清铁调素可能是尿毒症毒素中的一种,并且在促红细胞生成素耐药中发挥着重要作用。然而,进一步进行前瞻性研究以确认这些研究结果是很有必要的。

血清铁调素在非透析的慢性肾脏病(CKD)患者中的临床意义尚不清楚。近日,Scientific reports 杂志上发表了一篇研究文章,研究人员针对这一问题对在2011年至2016年期间韩国2238名非透析CKD患者进行了一项大规模多中心前瞻性研究。

该项研究在纳入研究对象时将排除了缺少血清铁调素(n=125)和血红蛋白(n=23)数据的患者,最后这项研究纳入了2090例非透析CKD患者。

研究人员发现患者炎症和铁状态标志物水平与血清铁调素水平呈正相关,无论患者处于何种CKD阶段。然而,估计的肾小球滤过率与血清铁调素水平呈负相关,特别是在CKD为3b-5期的患者,而在CKD1-3a期的患者不存在这种相关性。红细胞生成刺激剂的使用与血清铁调素水平升高呈正相关,特别是与CKD 3b-5期的患者,而不是在那些与CKD 1-3a期的患者,并且血清铁调素水平与红细胞生成刺激剂的剂量呈正相关。

这些研究结果表明血清铁调素可能是尿毒症毒素中的一种,并且在促红细胞生成素耐药中发挥着重要作用。然而,进一步进行前瞻性研究以确认这些研究结果是很有必要的。

原始出处:


Sung Woo Lee,et al. Serum hepcidin may be a novel uremic toxin, which might be related to erythropoietin resistance.Scientific reports. 2017. https://www.nature.com/articles/s41598-017-04664-y

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    2017-07-16 mnda
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    2017-06-28 tcm99hq
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    2017-06-26 1e1a50a1m36(暂无匿称)

    炎症和铁状态标志物水平与血清铁调素水平呈正相关

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