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Int J Nanomed：纳米结构羟基磷灰石微球负载BMP-2可实现快速骨再生

2018-08-05 MedSci MedSci原创

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组织工程是修复大块骨缺损的一种有前景的策略。植入材料的表面形态在骨愈合中起关键作用，这些材料结合了骨诱导因子，以提高骨再生的效率。 在目前的研究中，使用硅酸钙（CS）微球作为前体，通过水热转化法制备纳米结构羟基磷灰石（nHAp）微球；通过喷雾干燥法获得CS微球。由纳米晶须构建的nHAp微球显著提高了微球吸附生物活性蛋白（BMP-2）并减少其初始爆发释放的能力。为了评价微球的体内骨再生，常规羟

组织工程是修复大块骨缺损的一种有前景的策略。植入材料的表面形态在骨愈合中起关键作用，这些材料结合了骨诱导因子，以提高骨再生的效率。

在目前的研究中，使用硅酸钙（CS）微球作为前体，通过水热转化法制备纳米结构羟基磷灰石（nHAp）微球；通过喷雾干燥法获得CS微球。由纳米晶须构建的nHAp微球显著提高了微球吸附生物活性蛋白（BMP-2）并减少其初始爆发释放的能力。为了评价微球的体内骨再生，常规羟基磷灰石（HAp）和nHAp微球都装载有重组人骨形态发生蛋白-2（rhBMP-2）或不装载蛋白质，并将这些微球植入大鼠股骨缺损4周和8周。

三维（3D）微型计算机断层扫描（CT）和组织形态学观察结果表明，与载有rhBMP-2的常规HAp微球相比，纳米结构表面和rhBMP-2的组合明显改善了骨生成。

综上所述，该研究结果表明，具有纳米结构表面的nHAp微球吸附rhBMP-2以快速形成骨，因此，具有在骨组织再生中充当载体的潜力。

原始出处：

Zhou P, Wu J, et al., Loading BMP-2 on nanostructured hydroxyapatite microspheres for rapid bone regeneration. Int J Nanomedicine. 2018 Jul 11;13:4083-4092. doi: 10.2147/IJN.S158280. eCollection 2018.

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    2019-03-11 HNYYM

    #BMP#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1634039, encodeId=f05b1634039fa, content=<a href='/topic/show?id=596635e549' target=_blank style='color:#2F92EE;'>#BMP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3575, encryptionId=596635e549, topicName=BMP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d95322064897, createdName=HNYYM, createdTime=Mon Mar 11 01:47:00 CST 2019, time=2019-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1642654, encodeId=5e00164265481, content=<a href='/topic/show?id=814c35e6e2' target=_blank style='color:#2F92EE;'>#BMP-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3576, encryptionId=814c35e6e2, topicName=BMP-2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=120c22999408, createdName=12498f17m73暂无昵称, createdTime=Thu Sep 06 13:47:00 CST 2018, time=2018-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472142, encodeId=924b14e2142e9, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a4cf7208806, createdName=lsj630, createdTime=Tue Aug 07 05:47:00 CST 2018, time=2018-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609028, encodeId=efcd1609028b1, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Tue Aug 07 05:47:00 CST 2018, time=2018-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622129, encodeId=3cb5162212946, content=<a href='/topic/show?id=f41b8000867' target=_blank style='color:#2F92EE;'>#羟基磷灰石#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80008, encryptionId=f41b8000867, topicName=羟基磷灰石)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Tue Aug 07 05:47:00 CST 2018, time=2018-08-07, status=1, ipAttribution=)]
    2018-09-06 12498f17m73暂无昵称

    #BMP-2#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1634039, encodeId=f05b1634039fa, content=<a href='/topic/show?id=596635e549' target=_blank style='color:#2F92EE;'>#BMP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3575, encryptionId=596635e549, topicName=BMP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d95322064897, createdName=HNYYM, createdTime=Mon Mar 11 01:47:00 CST 2019, time=2019-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1642654, encodeId=5e00164265481, content=<a href='/topic/show?id=814c35e6e2' target=_blank style='color:#2F92EE;'>#BMP-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3576, encryptionId=814c35e6e2, topicName=BMP-2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=120c22999408, createdName=12498f17m73暂无昵称, createdTime=Thu Sep 06 13:47:00 CST 2018, time=2018-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472142, encodeId=924b14e2142e9, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a4cf7208806, createdName=lsj630, createdTime=Tue Aug 07 05:47:00 CST 2018, time=2018-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609028, encodeId=efcd1609028b1, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Tue Aug 07 05:47:00 CST 2018, time=2018-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622129, encodeId=3cb5162212946, content=<a href='/topic/show?id=f41b8000867' target=_blank style='color:#2F92EE;'>#羟基磷灰石#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80008, encryptionId=f41b8000867, topicName=羟基磷灰石)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Tue Aug 07 05:47:00 CST 2018, time=2018-08-07, status=1, ipAttribution=)]
    2018-08-07 lsj630

    #骨再生#

    0

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    2018-08-07 ms3994565386320060

    #Med#

    0

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    2018-08-07 爆笑小医

    #羟基磷灰石#

    0

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