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慢性移植物抗宿主病的治疗:Kadmon和Meiji宣布在日本合作开发ROCK2抑制剂KD025

2019-12-27 Allan MedSci原创

美国Kadmon和日本Meiji公司宣布,两家公司已建立战略合作关系,将在日本合作开发ROCK2抑制剂KD025用于治疗慢性移植物抗宿主病(cGVHD)。

急性和慢性移植物抗宿主病(GVHD)是多系统疾病,它是异基因造血干细胞移植的常见并发症。美国Kadmon和日本Meiji公司宣布,两家公司已建立战略合作关系,将在日本合作开发ROCK2抑制剂KD025用于治疗慢性移植物抗宿主病(cGVHD)。

Kadmon在美国正在进行一项关键临床试验,以验证ROCK2抑制剂KD025治疗慢性移植物抗宿主病(cGVHD)的有效性和安全性。201810月,美国食品药品监督管理局(FDA)向KD025授予了突破性治疗法称号,用于在两次或两次以上全身性治疗后治疗cGVHD


原始出处:

http://www.firstwordpharma.com/node/1690086?tsid=4#axzz69CnI0iLA

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    2020-02-20 anminleiryan
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    2020-07-13 xuyong535
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createdName=手留余香, createdTime=Sun Dec 29 09:33:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578849, encodeId=1e8715e8849de, content=<a href='/topic/show?id=7e74536097a' target=_blank style='color:#2F92EE;'>#慢性移植物抗宿主病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53609, encryptionId=7e74536097a, topicName=慢性移植物抗宿主病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2dc16449103, createdName=丁鹏鹏, createdTime=Sun Dec 29 09:33:00 CST 2019, time=2019-12-29, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1647690, encodeId=97d4164e690b3, content=<a href='/topic/show?id=d8a01999d2' target=_blank style='color:#2F92EE;'>#ADM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1999, encryptionId=d8a01999d2, topicName=ADM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=596423466663, createdName=anminleiryan, createdTime=Thu Feb 20 16:33:00 CST 2020, time=2020-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1745335, encodeId=19b71e453356e, content=<a href='/topic/show?id=bdc262694bb' target=_blank style='color:#2F92EE;'>#植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62694, encryptionId=bdc262694bb, topicName=植物)], attachment=null, authenticateStatus=null, createdAvatar=null, 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href='/topic/show?id=1a4f4649925' target=_blank style='color:#2F92EE;'>#宿主#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46499, encryptionId=1a4f4649925, topicName=宿主)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/08904ED76550A0090DB220A7FB81D755/100, createdBy=78512492586, createdName=wincls, createdTime=Sun Dec 29 09:33:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419728, encodeId=b73c1419e28e7, content=<a href='/topic/show?id=a798e520582' target=_blank style='color:#2F92EE;'>#移植物抗宿主病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75205, encryptionId=a798e520582, topicName=移植物抗宿主病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4d6c3527534, createdName=手留余香, createdTime=Sun Dec 29 09:33:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578849, encodeId=1e8715e8849de, content=<a href='/topic/show?id=7e74536097a' target=_blank style='color:#2F92EE;'>#慢性移植物抗宿主病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53609, encryptionId=7e74536097a, topicName=慢性移植物抗宿主病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2dc16449103, createdName=丁鹏鹏, createdTime=Sun Dec 29 09:33:00 CST 2019, time=2019-12-29, status=1, ipAttribution=)]
    2020-08-07 linlin2312
  6. [GetPortalCommentsPageByObjectIdResponse(id=1647690, encodeId=97d4164e690b3, content=<a href='/topic/show?id=d8a01999d2' target=_blank style='color:#2F92EE;'>#ADM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1999, encryptionId=d8a01999d2, topicName=ADM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=596423466663, createdName=anminleiryan, createdTime=Thu Feb 20 16:33:00 CST 2020, time=2020-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1745335, encodeId=19b71e453356e, content=<a href='/topic/show?id=bdc262694bb' target=_blank style='color:#2F92EE;'>#植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62694, encryptionId=bdc262694bb, topicName=植物)], attachment=null, authenticateStatus=null, createdAvatar=null, 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createdName=手留余香, createdTime=Sun Dec 29 09:33:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578849, encodeId=1e8715e8849de, content=<a href='/topic/show?id=7e74536097a' target=_blank style='color:#2F92EE;'>#慢性移植物抗宿主病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53609, encryptionId=7e74536097a, topicName=慢性移植物抗宿主病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2dc16449103, createdName=丁鹏鹏, createdTime=Sun Dec 29 09:33:00 CST 2019, time=2019-12-29, status=1, ipAttribution=)]
    2020-05-17 jklm09
  7. 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href='/topic/show?id=1a4f4649925' target=_blank style='color:#2F92EE;'>#宿主#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46499, encryptionId=1a4f4649925, topicName=宿主)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/08904ED76550A0090DB220A7FB81D755/100, createdBy=78512492586, createdName=wincls, createdTime=Sun Dec 29 09:33:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419728, encodeId=b73c1419e28e7, content=<a href='/topic/show?id=a798e520582' target=_blank style='color:#2F92EE;'>#移植物抗宿主病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75205, encryptionId=a798e520582, topicName=移植物抗宿主病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4d6c3527534, createdName=手留余香, createdTime=Sun Dec 29 09:33:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578849, encodeId=1e8715e8849de, content=<a href='/topic/show?id=7e74536097a' target=_blank style='color:#2F92EE;'>#慢性移植物抗宿主病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53609, encryptionId=7e74536097a, topicName=慢性移植物抗宿主病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2dc16449103, createdName=丁鹏鹏, createdTime=Sun Dec 29 09:33:00 CST 2019, time=2019-12-29, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1647690, encodeId=97d4164e690b3, content=<a href='/topic/show?id=d8a01999d2' target=_blank style='color:#2F92EE;'>#ADM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1999, encryptionId=d8a01999d2, topicName=ADM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=596423466663, createdName=anminleiryan, createdTime=Thu Feb 20 16:33:00 CST 2020, time=2020-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1745335, encodeId=19b71e453356e, content=<a href='/topic/show?id=bdc262694bb' target=_blank style='color:#2F92EE;'>#植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62694, encryptionId=bdc262694bb, topicName=植物)], attachment=null, authenticateStatus=null, createdAvatar=null, 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objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Sun May 17 18:33:00 CST 2020, time=2020-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1294517, encodeId=ad47129451e68, content=<a href='/topic/show?id=ca6e592189b' target=_blank style='color:#2F92EE;'>#日本#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59218, encryptionId=ca6e592189b, topicName=日本)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Sun Dec 29 09:33:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1404732, encodeId=52b51404e322e, content=<a href='/topic/show?id=1a4f4649925' target=_blank style='color:#2F92EE;'>#宿主#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46499, encryptionId=1a4f4649925, topicName=宿主)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/08904ED76550A0090DB220A7FB81D755/100, createdBy=78512492586, createdName=wincls, createdTime=Sun Dec 29 09:33:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419728, encodeId=b73c1419e28e7, content=<a href='/topic/show?id=a798e520582' target=_blank style='color:#2F92EE;'>#移植物抗宿主病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75205, encryptionId=a798e520582, topicName=移植物抗宿主病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4d6c3527534, createdName=手留余香, createdTime=Sun Dec 29 09:33:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578849, encodeId=1e8715e8849de, content=<a href='/topic/show?id=7e74536097a' target=_blank style='color:#2F92EE;'>#慢性移植物抗宿主病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53609, encryptionId=7e74536097a, topicName=慢性移植物抗宿主病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2dc16449103, createdName=丁鹏鹏, createdTime=Sun Dec 29 09:33:00 CST 2019, time=2019-12-29, status=1, ipAttribution=)]
    2019-12-29 wincls
  9. [GetPortalCommentsPageByObjectIdResponse(id=1647690, encodeId=97d4164e690b3, content=<a href='/topic/show?id=d8a01999d2' target=_blank style='color:#2F92EE;'>#ADM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1999, encryptionId=d8a01999d2, topicName=ADM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=596423466663, createdName=anminleiryan, createdTime=Thu Feb 20 16:33:00 CST 2020, time=2020-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1745335, encodeId=19b71e453356e, content=<a href='/topic/show?id=bdc262694bb' target=_blank style='color:#2F92EE;'>#植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62694, encryptionId=bdc262694bb, topicName=植物)], attachment=null, authenticateStatus=null, createdAvatar=null, 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  10. 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