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Radiology:能从MRI图像中发现提示胶质母细胞瘤生存期、手术效果的线索吗?

2018-11-06 shaosai MedSci原创

本研究旨在通过术前增强容积T1W MRI序列作为评价胶质母细胞瘤预测手术效果及生存期影像学指标的价值。

本研究旨在通过术前增强容积T1W MRI序列作为评价胶质母细胞瘤预测手术效果及生存期影像学指标的价值。

本研究共纳入了5个中心的165例患者和51例用来独立验证的患者,均行术前对比增强容积T1W MRI,收集患者临床指标如性别、年龄、治疗和生存期。经过肿瘤分割和图像处理后,评价肿瘤表面不规则性和肿瘤偏离相同体积球体程度。利用Kaplan-Meier、Cox比例危害检验、相关性分析和一致性指数比较变量和患者亚组。

结果为,在识别组(P = .005, HR = 1.61)和验证组(P = .05, HR = 1.84),肿瘤表面不规则性是预测生存期强有力的指标。多变量分析将年龄和表面不规则性作为显着性指标纳入到预后模型中(P < .001, HR = 3.05)。在识别组和验证组,该模型的一致性指数分别为0.76、0.74。肿瘤表面不规则性是肿瘤完全切除患者生存期的预测指标(P = .01, HR = 1.90)。表面不规则肿瘤患者在次全切除后患者获益较小(P = .57, HR = 1.17),而表面规则肿瘤获益较大(P = .004, HR = 2.07)。

本研究表明,高分辨对比增强容积T1W MR图像中表明不规则性是预测胶质母细胞瘤生存期的预测指标,它有助于对手术患者手术方法决策的制定。

原始出处:

Pérez-Beteta J, Molina-García D, Ortiz-Alhambra JA. et al.Tumor Surface Regularity at MR Imaging Predicts Survival and Response to Surgery in Patients with Glioblastoma.Radiology.DOI:10.1148/radiol.2018171051

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    2018-11-06 CHANGE

    疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的

    0

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