Thyroid：乳腺癌和甲状腺癌常出现在同一人身上，是偶然还是必然？

2015-11-02 Mechront 译 MedSci原创

先前有证据指出，同一女性发生乳腺癌和甲状腺癌的频率看似并不是偶然。那么乳腺癌和甲状腺癌之间究竟有没有联系呢？研究者进行了一项研究，调查甲状腺癌患者发生乳腺癌和乳腺癌患者发生甲状腺癌的患病率和临床病理的特点。该回顾性病例对照研究纳入了4243名已分化的甲状腺癌患者和6833名乳腺癌患者。通过年龄匹配没有第二原发肿瘤的患者。研究结果显示，在4243名甲状腺癌患者中，有55名在平均5年（2-40年）的随

先前有证据指出，同一女性发生乳腺癌和甲状腺癌的频率看似并不是偶然。那么乳腺癌和甲状腺癌之间究竟有没有联系呢？研究者进行了一项研究，调查甲状腺癌患者发生乳腺癌和乳腺癌患者发生甲状腺癌的患病率和临床病理的特点。

该回顾性病例对照研究纳入了4243名已分化的甲状腺癌患者和6833名乳腺癌患者。通过年龄匹配没有第二原发肿瘤的患者。

研究结果显示，在4243名甲状腺癌患者中，有55名在平均5年（2-40年）的随访时间内发生了乳腺癌；标准发生率 (SIR) 是2.45 [CI 1.83-2.96]。6833名乳腺癌患者在6.2年（2-40年）随访期间，有81名患者发生了甲状腺癌，SIR=2.18 [CI 1.43-2.82]。在诊断首发肿瘤后5年内，随后发生第二原发乳腺癌或甲状腺癌的患者，比对照组有更多的与早期癌症一致的临床特征。尤其是乳腺癌和甲状腺癌共存的患者，其组织内雌孕激素受体显著高于单独乳腺癌患者。

研究结果表明，乳腺癌或甲状腺癌患者，其后发生第二原发肿瘤甲状腺癌或乳腺癌D 风险增加。早期对第二原发肿瘤进行检测可以早发现早治疗。对于乳腺癌和甲状腺癌共存患者表现出的高激素受体，暗示了甲状腺癌和乳腺癌的分子病理间有联系。

原始出处：

An JH, Hwangbo Y, Ahn HY,et al.A Possible Association Between Thyroid Cancer and Breast Cancer.Thyroid. 2015 Oct 27.

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2016-08-03 1dd8c52fm63(暂无匿称)

了解一下！

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2016-04-10 忠诚向上

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2016-04-10 忠诚向上

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82 0
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2016-04-10 忠诚向上

值得学习

164 0
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2016-04-10 忠诚向上

值得学习

140 0
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2016-04-10 忠诚向上

值得学习

117 0
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2016-04-10 忠诚向上

值得学习

81 0
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2016-04-10 忠诚向上

值得学习

155 0
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2016-04-10 忠诚向上

值得学习

121 0
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2016-04-10 忠诚向上

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