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Heart:动脉僵硬度对无高血压患者心血管结局的影响!

2017-08-17 xing.T MedSci原创

由此可见,高baPWV与更高的CAC评分以及未来心血管事件风险相关,尤其是冠状动脉疾病,即使在无高血压的患者中。

虽然血压(BP)是动脉僵硬度的主要决定因素,然而,高脉搏波传导速度(PWV)是否会对无高血压患者的心脏参数和心血管(CV)预后产生不良影响尚不清楚。

近日,在心脏病领域权威杂志Heart上发表了一篇研究文章,研究人员纳入了门诊无高血压的患者(n=320),高血压定义为收缩压≥140 mmHg,进行回顾性研究。在基线时,所有患者均行超声和螺旋CT检查以确定冠状动脉钙化(CAC)得分。动脉硬化评估是基于臂踝PWV(baPWV),并将患者分为两组:高baPWV组(≥18m/s,n=89)和低baPWV组(<18m/s,n=231)。研究人员比较了各组随访期间心脏参数及心血管事件发生率。

在多变量线性回归分析中,在调整混杂因素后,baPWV与CAC评分、血清氨基末端脑钠肽前体激素水平之间存在显著的相关性。在多变量Logistic回归分析中,baPWV≥18m/s与CAC评分≥400显著相关(比值比为2.466,95%CI为1.012-6.009,P=0.0471)。Kaplan Meier分析表明,在575天的随访期间,高baPWV组受试者出现了更多的心血管事件(20% vs. 6%,P=0.0003)。

由此可见,高baPWV与更高的CAC评分以及未来心血管事件风险相关,尤其是冠状动脉疾病,即使在无高血压的患者中。

原始出处:

Keishi Ichikawa,et al. Influence of arterial stiffness on cardiovascular outcome in patients without high blood pressure. Heart. 2017. http://dx.doi.org/10.1136/heartjnl-2017-311751

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    2017-08-19 slcumt
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    2017-08-17 tanxingdoctor

    学习啦

    0

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2013年6月14日,在意大利米兰举行的欧洲高血压学会(ESH)2013科学年会上,ESH/欧洲心脏病学会(ESC)联合发布了2013年动脉高血压管理指南,该指南对高血压的治疗建议作了重要变动,同时也对女性高血压的治疗作了科学建议。高血压是“全球死亡风险最高的疾病”,对高血压进行有效的控制是减少心血管事件的重要手段。在高血压人群中,女性因为特殊的体质、心理以及遗传特点,其血压的变化不同于男

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