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Clinica Chimica Acta:抗ZNT8自身抗体: 筛选抗肾上腺抗体患者的新标志物

2021-01-03 MedSci原创 MedSci原创

患自身免疫性阿狄森氏病(AAD)疾病的人可发展为其他自身免疫性疾病。由于他们经常显示自身抗体而不是抗肾上腺皮质自身抗体(ACA),因此可能对预测其他疾病如1型糖尿病(T1D)的发展可能有意义。

患自身免疫性阿狄森氏病(AAD)疾病的人可发展为其他自身免疫性疾病。由于他们经常显示自身抗体而不是抗肾上腺皮质自身抗体(ACA),因此可能对预测其他疾病如1型糖尿病(T1D)的发展可能有意义。在成熟的T1D相关自身抗体中,可以发现znt8自身抗体(ZnT8A),但不含GADA抗体和IA2A抗体。因此,本研究的目的是评估ZnT8A在AAD患者队列中的流行率。

研究了36名ACA患者(19名儿童和17名成人)ZnT8A的情况。ZnT8A在儿童和成人中均检测到,总体流行率为19%。此外,研究结果还表明,无论年龄大小,70%以上的人群中ZnT8A与T1D共存相关。即使另外30%没有T1D的患者的ZnT8A滴度较低,但由于存在发生T1D的潜在风险,仍需进行随访。这些病例中的ZnT8A也可能是AAD中与肾上腺损伤相关的自身免疫标志物。

本研究认为:由于ZnT8A筛查已被纳入T1D诊断研究,因此,也应纳入AAD人群自身抗体筛查。

原始出处:

Bost Chloé,Teoli JordanAnti-ZnT8 autoantibodies: A new marker to be screened in patients with anti-adrenal antibodies

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    2021-09-08 windight
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