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英国MHRA开始对Moderna新冠病毒疫苗进行滚动审查

2020-11-01 MedSci原创 MedSci原创

mRNA-1273第一阶段研究中期分析结果显示,接受两剂疫苗的参与者对SARS-CoV-2具有快速且强烈的免疫反应。

英国药品和保健产品监管局(MHRA)已开始对Moderna基于mRNA的COVID-19疫苗mRNA-1273进行滚动审查,这意味着MHRA将对Moderna的疫苗开展独立评估。

Moderna Awarded USD 483 Million by BARDA for Advancing mRNA Vaccine against  Coronavirus - COVID-19 - Hospimedica.com

Moderna的mRNA疫苗(图片来源:https://www.hospimedica.com/covid-19/articles/294781771/moderna-awarded-usd-483-million-by-barda-for-advancing-mrna-vaccine-against-coronavirus.html)

上周,Moderna在30,000名参与者中完成了其3期临床试验mRNA-1273的注册。据该公司称,现在有25654名参与者在3期COVE研究中接受了候选疫苗的第二次疫苗接种。

Moderna的COVID-19疫苗以创纪录的时间进入到3期临床研究,美国国立卫生研究院(NIH)于7月启动了COVE研究。

mRNA-1273第一阶段研究中期分析结果显示,接受两剂疫苗的参与者对SARS-CoV-2具有快速且强烈的免疫反应。

Moderna首席医学官Tal Zaks表示:“1期数据证明接种mRNA-1273疫苗可在所有剂量水平上产生强烈的免疫反应,并明确在初免和加强方案中选择100 µg作为最佳剂量。”

mRNA-1273的临床开发正在与美国国家过敏和传染病研究所(NIAID)合作进行,美国政府将Moderna选为“ Operation Warp Speed”计划。

原始出处:

http://www.pmlive.com/pharma_news/uks_mhra_begins_rolling_review_of_modernas_coronavirus_vaccine_1355357

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    2021-05-07 般若傻瓜
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level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201028/f392697b67704065936a7d71c903356a/fc8145bc7e334842b4af1845278faea4.jpg, createdBy=60255339175, createdName=ms3000002005028696, createdTime=Mon Nov 02 03:17:05 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028721, encodeId=8e061028e217d, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Mon Nov 02 02:45:52 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896145, encodeId=eae0896145cd, content=启动滚动调查, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bb45125889, createdName=146465bem06暂无昵称, createdTime=Mon Nov 02 00:11:30 CST 2020, time=2020-11-02, status=1, ipAttribution=)]
    2020-11-02 周泡泡

    #学习#新冠肺炎

    0

  5. 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level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201028/f392697b67704065936a7d71c903356a/fc8145bc7e334842b4af1845278faea4.jpg, createdBy=60255339175, createdName=ms3000002005028696, createdTime=Mon Nov 02 03:17:05 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028721, encodeId=8e061028e217d, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Mon Nov 02 02:45:52 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896145, encodeId=eae0896145cd, content=启动滚动调查, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bb45125889, createdName=146465bem06暂无昵称, createdTime=Mon Nov 02 00:11:30 CST 2020, time=2020-11-02, status=1, ipAttribution=)]
    2020-11-02 lovetcm

    #新冠病毒疫苗#会在中国之前被批准,还是之后?大家要抢是这个月还是下个月!

    0

  6. 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level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201028/f392697b67704065936a7d71c903356a/fc8145bc7e334842b4af1845278faea4.jpg, createdBy=60255339175, createdName=ms3000002005028696, createdTime=Mon Nov 02 03:17:05 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028721, encodeId=8e061028e217d, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Mon Nov 02 02:45:52 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896145, encodeId=eae0896145cd, content=启动滚动调查, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bb45125889, createdName=146465bem06暂无昵称, createdTime=Mon Nov 02 00:11:30 CST 2020, time=2020-11-02, status=1, ipAttribution=)]
    2020-11-02 qingzipost

    值得学习!

    0

  7. 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level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201028/f392697b67704065936a7d71c903356a/fc8145bc7e334842b4af1845278faea4.jpg, createdBy=60255339175, createdName=ms3000002005028696, createdTime=Mon Nov 02 03:17:05 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028721, encodeId=8e061028e217d, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Mon Nov 02 02:45:52 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896145, encodeId=eae0896145cd, content=启动滚动调查, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bb45125889, createdName=146465bem06暂无昵称, createdTime=Mon Nov 02 00:11:30 CST 2020, time=2020-11-02, status=1, ipAttribution=)]
    2020-11-02 Jason20042008

    抢票的节奏!

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1648489, encodeId=3c9616484891e, content=<a href='/topic/show?id=c3b68e084ff' target=_blank style='color:#2F92EE;'>#英国MHRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87084, encryptionId=c3b68e084ff, topicName=英国MHRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e32f23584568, createdName=minzju5060, createdTime=Sun Jun 13 11:45:52 CST 2021, time=2021-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2083338, encodeId=8152208333856, content=<a href='/topic/show?id=b7cce09742a' target=_blank style='color:#2F92EE;'>#病毒疫苗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70974, encryptionId=b7cce09742a, topicName=病毒疫苗)], attachment=null, authenticateStatus=null, createdAvatar=null, 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encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=49465429256, createdName=周泡泡, createdTime=Mon Nov 02 19:50:36 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896187, encodeId=354c89618e27, content=<a href='/topic/show?id=6b54580e217' target=_blank style='color:#2F92EE;'>#新冠病毒疫苗#</a>会在中国之前被批准,还是之后?大家要抢是这个月还是下个月!, beContent=null, objectType=article, channel=null, level=null, likeNumber=229, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58072, encryptionId=6b54580e217, topicName=新冠病毒疫苗)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Nov 02 09:35:04 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896151, encodeId=e18c89615172, content=值得学习!, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210724/c645b03bf7334ae9851463b07f0c8f68/b29977d0d19a42f9881060d301f0a012.jpg, createdBy=3f901635259, createdName=qingzipost, createdTime=Mon Nov 02 06:32:55 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896150, encodeId=cfec89615028, content=抢票的节奏!, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=287c2410703, createdName=Jason20042008, createdTime=Mon Nov 02 04:00:46 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896147, encodeId=138189614e57, content=好快的速度, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201028/f392697b67704065936a7d71c903356a/fc8145bc7e334842b4af1845278faea4.jpg, createdBy=60255339175, createdName=ms3000002005028696, createdTime=Mon Nov 02 03:17:05 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028721, encodeId=8e061028e217d, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Mon Nov 02 02:45:52 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896145, encodeId=eae0896145cd, content=启动滚动调查, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bb45125889, createdName=146465bem06暂无昵称, createdTime=Mon Nov 02 00:11:30 CST 2020, time=2020-11-02, status=1, ipAttribution=)]
    2020-11-02 ms3000002005028696

    好快的速度

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1648489, encodeId=3c9616484891e, content=<a href='/topic/show?id=c3b68e084ff' target=_blank style='color:#2F92EE;'>#英国MHRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87084, encryptionId=c3b68e084ff, topicName=英国MHRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e32f23584568, createdName=minzju5060, createdTime=Sun Jun 13 11:45:52 CST 2021, time=2021-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2083338, encodeId=8152208333856, content=<a href='/topic/show?id=b7cce09742a' target=_blank style='color:#2F92EE;'>#病毒疫苗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70974, encryptionId=b7cce09742a, topicName=病毒疫苗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1dbc2500219, createdName=huagfeg, createdTime=Mon Feb 15 00:45:52 CST 2021, time=2021-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2008770, encodeId=94f52008e7088, content=<a href='/topic/show?id=db6969548d' target=_blank style='color:#2F92EE;'>#eRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6954, encryptionId=db6969548d, topicName=eRNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad9f79, createdName=般若傻瓜, createdTime=Fri May 07 14:45:52 CST 2021, time=2021-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896366, encodeId=602d8963662d, content=<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>新冠肺炎, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210724/c645b03bf7334ae9851463b07f0c8f68/b29977d0d19a42f9881060d301f0a012.jpg, createdBy=3f901635259, createdName=qingzipost, createdTime=Mon Nov 02 06:32:55 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896150, encodeId=cfec89615028, content=抢票的节奏!, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=287c2410703, createdName=Jason20042008, createdTime=Mon Nov 02 04:00:46 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896147, encodeId=138189614e57, content=好快的速度, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201028/f392697b67704065936a7d71c903356a/fc8145bc7e334842b4af1845278faea4.jpg, createdBy=60255339175, createdName=ms3000002005028696, createdTime=Mon Nov 02 03:17:05 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028721, encodeId=8e061028e217d, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Mon Nov 02 02:45:52 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896145, encodeId=eae0896145cd, content=启动滚动调查, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bb45125889, createdName=146465bem06暂无昵称, createdTime=Mon Nov 02 00:11:30 CST 2020, time=2020-11-02, status=1, ipAttribution=)]
    2020-11-02 公卫新人

    新冠肺炎,疫情何时才能消失

    0

  10. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210724/c645b03bf7334ae9851463b07f0c8f68/b29977d0d19a42f9881060d301f0a012.jpg, createdBy=3f901635259, createdName=qingzipost, createdTime=Mon Nov 02 06:32:55 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896150, encodeId=cfec89615028, content=抢票的节奏!, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=287c2410703, createdName=Jason20042008, createdTime=Mon Nov 02 04:00:46 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896147, encodeId=138189614e57, content=好快的速度, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201028/f392697b67704065936a7d71c903356a/fc8145bc7e334842b4af1845278faea4.jpg, createdBy=60255339175, createdName=ms3000002005028696, createdTime=Mon Nov 02 03:17:05 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028721, encodeId=8e061028e217d, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Mon Nov 02 02:45:52 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896145, encodeId=eae0896145cd, content=启动滚动调查, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bb45125889, createdName=146465bem06暂无昵称, createdTime=Mon Nov 02 00:11:30 CST 2020, time=2020-11-02, status=1, ipAttribution=)]
    2020-11-02 146465bem06暂无昵称

    启动滚动调查

    0

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