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J Endod：搅碎牙髓作为牙髓间充质干细胞来源的成牙本质分化能力研究

2017-11-05 lishiting MedSci原创

搅碎牙髓MSC牙髓再生
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通过多种临床探索发现牙髓中存在间充质干细胞(MSCs)，这促使牙髓组织的再生成为可能，尽管体外扩展和培养的MSC植入髓腔还存在诸多困难。搅碎的牙髓组织作为牙髓MSCs的来源，可以绕过体外MSC培养调控和技术的复杂性。在此，研究者探讨搅碎牙髓的组织再生能力。

通过多种临床探索发现牙髓中存在间充质干细胞(MSCs)，这促使牙髓组织的再生成为可能，尽管体外扩展和培养的MSC植入髓腔还存在诸多困难。搅碎的牙髓组织作为牙髓MSCs的来源，可以绕过体外MSC培养调控和技术的复杂性。在此，研究者探讨搅碎牙髓的组织再生能力。研究对来源于搅碎牙髓(MP)的细胞表型进行鉴定，将其命名为来源于MP的MSC (MP-MSCs)，并与通过酶消化法从牙髓中提取的牙髓干细胞(DPSCs)进行比较。表型特征包括：复制动力学、免疫表型和多项分化能力。通过牙齿切片模型原位分析DPSCs、MP-MSCs和搅碎牙髓组织的成牙本质/成骨分化能力差异。结果显示，与DPSCs相比较，MP-MSCs在最初的传代培养过程中其体外复制发生更迅速。然而，MP-MSCs传到47代时达到细胞衰老的状态，而DPSCs直传到64代才达到此种状态，表明MP-MSCs的复制周期较短。通过碱性磷酸酶和蛋白表达的检测也发现，MP-MSCs比DPSCs具有更强的成牙本质/成骨分化能力。另外，MP-MSCs和DPSCs均展现出具有成牙本质/成骨和成脂分化的能力。2种类型的细胞在牙齿切片模型上也具有形成矿化组织的

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1669615, encodeId=c3af166961552, content=<a href='/topic/show?id=c7ca6e660ab' target=_blank style='color:#2F92EE;'>#牙髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67660, encryptionId=c7ca6e660ab, topicName=牙髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5eeb26562774, createdName=jxrzshh, createdTime=Tue Oct 02 22:14:00 CST 2018, time=2018-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815271, encodeId=5db818152e159, content=<a href='/topic/show?id=ae359e231d4' target=_blank style='color:#2F92EE;'>#间充质干细#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97231, encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Sun Jan 21 02:14:00 CST 2018, time=2018-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441878, encodeId=b50414418e8f5, content=<a href='/topic/show?id=67526e55924' target=_blank style='color:#2F92EE;'>#牙本质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67559, encryptionId=67526e55924, topicName=牙本质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=37364903098, createdName=ms8538335253054589, createdTime=Tue Nov 07 03:14:00 CST 2017, time=2017-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258913, encodeId=7c9325891311, content=通过多种临床探索发现牙髓中存在间充质干细胞(MSCs).这促使牙髓组织的再生成为可能.尽管体外扩展和培养的MSC植入髓腔还存在诸多困难.搅碎的牙髓组织作为牙髓MSCs的来源.可以绕过体外MSC培养调控和技术的复杂性.在此.研究者探讨搅碎牙髓的组织再生能力, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sun Nov 05 17:16:19 CST 2017, time=2017-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258887, encodeId=42e825888ef6, content=很好的文章.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Nov 05 12:55:09 CST 2017, time=2017-11-05, status=1, ipAttribution=)]
    2018-10-02 jxrzshh

    #牙髓#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1669615, encodeId=c3af166961552, content=<a href='/topic/show?id=c7ca6e660ab' target=_blank style='color:#2F92EE;'>#牙髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67660, encryptionId=c7ca6e660ab, topicName=牙髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5eeb26562774, createdName=jxrzshh, createdTime=Tue Oct 02 22:14:00 CST 2018, time=2018-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815271, encodeId=5db818152e159, content=<a href='/topic/show?id=ae359e231d4' target=_blank style='color:#2F92EE;'>#间充质干细#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97231, encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Sun Jan 21 02:14:00 CST 2018, time=2018-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441878, encodeId=b50414418e8f5, content=<a href='/topic/show?id=67526e55924' target=_blank style='color:#2F92EE;'>#牙本质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67559, encryptionId=67526e55924, topicName=牙本质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=37364903098, createdName=ms8538335253054589, createdTime=Tue Nov 07 03:14:00 CST 2017, time=2017-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258913, encodeId=7c9325891311, content=通过多种临床探索发现牙髓中存在间充质干细胞(MSCs).这促使牙髓组织的再生成为可能.尽管体外扩展和培养的MSC植入髓腔还存在诸多困难.搅碎的牙髓组织作为牙髓MSCs的来源.可以绕过体外MSC培养调控和技术的复杂性.在此.研究者探讨搅碎牙髓的组织再生能力, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sun Nov 05 17:16:19 CST 2017, time=2017-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258887, encodeId=42e825888ef6, content=很好的文章.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Nov 05 12:55:09 CST 2017, time=2017-11-05, status=1, ipAttribution=)]
    2018-01-21 h.y200607_23674418

    #间充质干细#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1669615, encodeId=c3af166961552, content=<a href='/topic/show?id=c7ca6e660ab' target=_blank style='color:#2F92EE;'>#牙髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67660, encryptionId=c7ca6e660ab, topicName=牙髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5eeb26562774, createdName=jxrzshh, createdTime=Tue Oct 02 22:14:00 CST 2018, time=2018-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815271, encodeId=5db818152e159, content=<a href='/topic/show?id=ae359e231d4' target=_blank style='color:#2F92EE;'>#间充质干细#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97231, encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Sun Jan 21 02:14:00 CST 2018, time=2018-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441878, encodeId=b50414418e8f5, content=<a href='/topic/show?id=67526e55924' target=_blank style='color:#2F92EE;'>#牙本质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67559, encryptionId=67526e55924, topicName=牙本质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=37364903098, createdName=ms8538335253054589, createdTime=Tue Nov 07 03:14:00 CST 2017, time=2017-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258913, encodeId=7c9325891311, content=通过多种临床探索发现牙髓中存在间充质干细胞(MSCs).这促使牙髓组织的再生成为可能.尽管体外扩展和培养的MSC植入髓腔还存在诸多困难.搅碎的牙髓组织作为牙髓MSCs的来源.可以绕过体外MSC培养调控和技术的复杂性.在此.研究者探讨搅碎牙髓的组织再生能力, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sun Nov 05 17:16:19 CST 2017, time=2017-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258887, encodeId=42e825888ef6, content=很好的文章.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Nov 05 12:55:09 CST 2017, time=2017-11-05, status=1, ipAttribution=)]
    2017-11-07 ms8538335253054589

    #牙本质#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1669615, encodeId=c3af166961552, content=<a href='/topic/show?id=c7ca6e660ab' target=_blank style='color:#2F92EE;'>#牙髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67660, encryptionId=c7ca6e660ab, topicName=牙髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5eeb26562774, createdName=jxrzshh, createdTime=Tue Oct 02 22:14:00 CST 2018, time=2018-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815271, encodeId=5db818152e159, content=<a href='/topic/show?id=ae359e231d4' target=_blank style='color:#2F92EE;'>#间充质干细#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97231, encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Sun Jan 21 02:14:00 CST 2018, time=2018-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441878, encodeId=b50414418e8f5, content=<a href='/topic/show?id=67526e55924' target=_blank style='color:#2F92EE;'>#牙本质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67559, encryptionId=67526e55924, topicName=牙本质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=37364903098, createdName=ms8538335253054589, createdTime=Tue Nov 07 03:14:00 CST 2017, time=2017-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258913, encodeId=7c9325891311, content=通过多种临床探索发现牙髓中存在间充质干细胞(MSCs).这促使牙髓组织的再生成为可能.尽管体外扩展和培养的MSC植入髓腔还存在诸多困难.搅碎的牙髓组织作为牙髓MSCs的来源.可以绕过体外MSC培养调控和技术的复杂性.在此.研究者探讨搅碎牙髓的组织再生能力, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sun Nov 05 17:16:19 CST 2017, time=2017-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258887, encodeId=42e825888ef6, content=很好的文章.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Nov 05 12:55:09 CST 2017, time=2017-11-05, status=1, ipAttribution=)]
    2017-11-05 有备才能无患

    通过多种临床探索发现牙髓中存在间充质干细胞(MSCs).这促使牙髓组织的再生成为可能.尽管体外扩展和培养的MSC植入髓腔还存在诸多困难.搅碎的牙髓组织作为牙髓MSCs的来源.可以绕过体外MSC培养调控和技术的复杂性.在此.研究者探讨搅碎牙髓的组织再生能力

    0

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    2017-11-05 清风拂面

    很好的文章.谢谢

    0

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