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Clin Immunol:过敏性鼻炎患者对屋尘螨增加的先天2型免疫响应

2017-09-30 AlexYang MedSci原创

2型先天淋巴样细胞(ILC2s)在起始和促进过敏免疫响应中是必要的成员。然而,研究人员在探究过程中发现了ILC2水平的过敏性鼻炎(AR)患者中的不一致性。最近,有研究人员调查了ILC2在屋尘螨(HDM)过敏性AR病人外周血中的水平,并且还调查了他们分泌2型细胞激素的能力。研究发现,ILC2s且具有ILC2表型特性的水平在HDM-AR病人中增加。AR病人的症状得分和IL-13的水平与HDM-AR病人

2型先天淋巴样细胞(ILC2s)在起始和促进过敏免疫响应中是必要的成员。然而,研究人员在探究过程中发现了ILC2水平的过敏性鼻炎(AR)患者中的不一致性。最近,有研究人员调查了ILC2在屋尘螨(HDM)过敏性AR病人外周血中的水平,并且还调查了他们分泌2型细胞激素的能力。研究发现,ILC2s且具有ILC2表型特性的水平在HDM-AR病人中增加。AR病人的症状得分和IL-13的水平与HDM-AR病人中的ILC2s有着正相关关系。另外,上皮细胞因子的刺激诱导了IL-5和IL-13在AR病人PBMCs中剧烈的产生。研究人员还成功的从AR病人中分离了ILC2s,并且鉴定了他们产生2型细胞激素的能力。研究还发现了ILC2s的数目在HDM-AR病人中增加了并且在上皮细胞激素存在的情况下,ILC2s产生了大量的TH2细胞激素,这也表明了ILC2在AR病人中的重要角色。原始出处:Zhong H, Fan XL, Yu QN et al. Increased innate type 2 immune response in house dust mite-allergic patients with a

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    2017-10-03 半夏微凉

    学习了谢谢分享

    0

  4. 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content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Oct 01 08:14:45 CST 2017, time=2017-10-01, status=1, ipAttribution=)]
    2017-10-03 chunjianf

    学习了.谢谢分享

    0

  5. 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    2017-10-03 明天会更好!

    谢谢分享.学习了

    0

  6. 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content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Oct 01 08:14:45 CST 2017, time=2017-10-01, status=1, ipAttribution=)]
    2017-10-01 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1944050, encodeId=9e7f19440506b, content=<a href='/topic/show?id=f48228993d0' target=_blank style='color:#2F92EE;'>#免疫响应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28993, encryptionId=f48228993d0, topicName=免疫响应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c82369, createdName=jiekemin, createdTime=Wed Nov 22 02:28:00 CST 2017, time=2017-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2046888, encodeId=aca4204688820, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, 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likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Sun Oct 01 08:36:45 CST 2017, time=2017-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249325, encodeId=9286249325cb, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sun Oct 01 08:18:11 CST 2017, time=2017-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249316, encodeId=e24f249316e6, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Oct 01 08:14:45 CST 2017, time=2017-10-01, status=1, ipAttribution=)]
    2017-10-01 执着追梦

    学习.谢谢分享

    0

  9. 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content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Oct 01 08:14:45 CST 2017, time=2017-10-01, status=1, ipAttribution=)]
    2017-10-01 明月清辉

    谢谢分享.学习了

    0

  10. 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likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Sun Oct 01 08:36:45 CST 2017, time=2017-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249325, encodeId=9286249325cb, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sun Oct 01 08:18:11 CST 2017, time=2017-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249316, encodeId=e24f249316e6, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Oct 01 08:14:45 CST 2017, time=2017-10-01, status=1, ipAttribution=)]
    2017-10-01 Y—xianghai

    学习了新知识

    0

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