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Sci Signal：基因表达的先后次序决定沙门氏菌表面脂多糖的修饰特征

2018-05-14 重磅学术期刊 学术经纬

脂多糖沙门氏菌多粘菌素B
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对革兰氏阴性菌表面的脂多糖(lipopolysaccharide， LPS)的修饰可以被用来逃避宿主的免疫反应或产生对抗生素的抗性。

对革兰氏阴性菌表面的脂多糖(lipopolysaccharide， LPS)的修饰可以被用来逃避宿主的免疫反应或产生对抗生素的抗性。例如，降低LPS中脂质A(lipid A)负电荷的修饰能够提高沙门氏菌(Salmonella)对多粘菌素B(polymyxin B)和其它阳离子抗菌素的抗性。耶鲁大学医学院(Yale School of Medicine)的研究人员发现不同刺激虽然在沙门氏菌中激发同样一组脂质A修饰酶的生成，但是它们可以造成不同的脂质A修饰特征。原因是不同刺激激活编码脂质A修饰酶的基因的动力学特征不同，这导致不同种脂质A修饰酶产生的时间顺序出现了变化，从而改变了脂质A的修饰特征和对多粘菌素B的抗性。这项研究揭示了细菌利用有限数量的酶来针对不同刺激生成多种适应反应的机制。

原始出处：

Xinyu Hong.et al.Gene expression kinetics governs stimulus-specific decoration of the Salmonella outer membrane.Sci Signal.08 May 2018：Vol. 11， Issue 529， eaar7921

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    2018-05-26 yaanren

    #Signal#

    0

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    2018-05-28 楚秀娟

    #Sign#

    0

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    2018-05-16 bioon1

    #基因表达#

    0

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href='/topic/show?id=1c562e42646' target=_blank style='color:#2F92EE;'>#修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27426, encryptionId=1c562e42646, topicName=修饰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c615505859, createdName=zhangyxzsh, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315423, encodeId=543b31542322, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Tue May 15 22:02:51 CST 2018, time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315400, encodeId=d2be31540044, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Tue May 15 19:51:37 CST 2018, time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315071, encodeId=b7e83150e1da, content=对革兰氏阴性菌表面的脂多糖(lipopolysaccharide.LPS)的修饰可以被用来逃避宿主的免疫反应或产生对抗生素的抗性.例如.降低LPS中脂质A(lipidA)负电荷的修饰能够提高沙门氏菌(Salmonella)对多粘菌素B(polymyxinB)和其它阳离子抗菌素的抗性., beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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    2018-05-16 lifestar

    #沙门氏菌#

    0

  5. 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    2018-05-16 小刀医生

    #脂多糖#

    0

  6. 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href='/topic/show?id=1c562e42646' target=_blank style='color:#2F92EE;'>#修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27426, encryptionId=1c562e42646, topicName=修饰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c615505859, createdName=zhangyxzsh, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315423, encodeId=543b31542322, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Tue May 15 22:02:51 CST 2018, time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315400, encodeId=d2be31540044, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Tue May 15 19:51:37 CST 2018, time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315071, encodeId=b7e83150e1da, content=对革兰氏阴性菌表面的脂多糖(lipopolysaccharide.LPS)的修饰可以被用来逃避宿主的免疫反应或产生对抗生素的抗性.例如.降低LPS中脂质A(lipidA)负电荷的修饰能够提高沙门氏菌(Salmonella)对多粘菌素B(polymyxinB)和其它阳离子抗菌素的抗性., beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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    2018-05-16 zhangyxzsh

    #修饰#

    0

  7. 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    2018-05-15 changjiu

    学习一下谢谢

    0

  8. 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    2018-05-15 131****1460

    学习了受益匪浅

    0

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    2018-05-14 有备才能无患

    对革兰氏阴性菌表面的脂多糖(lipopolysaccharide.LPS)的修饰可以被用来逃避宿主的免疫反应或产生对抗生素的抗性.例如.降低LPS中脂质A(lipidA)负电荷的修饰能够提高沙门氏菌(Salmonella)对多粘菌素B(polymyxinB)和其它阳离子抗菌素的抗性.

    0

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