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Anesth Analg:术前血清氯化物水平与非心脏手术后死亡率和发病率的相关性:回顾性队列研究

2019-12-06 anesthGH “罂粟花”微信号

已知术后高氯血症与手术后死亡率和发病率的增加有关。然而,术前高氯血症和低氯血症与术后死亡率和发病率的关系尚不清楚。我们的目的是用术前血清氯化物试验进行评估术前高氯血症或低氯血症与非心脏手术后90天死亡率和发病率之间的关系。

背景与目的

已知术后高氯血症与手术后死亡率和发病率的增加有关。然而,术前高氯血症和低氯血症与术后死亡率和发病率的关系尚不清楚。我们的目的是用术前血清氯化物试验进行评估术前高氯血症或低氯血症与非心脏手术后90天死亡率和发病率之间的关系。

方  法

在这项回顾性队列研究中,我们回顾了2010年1月至2016年12月接受非心脏手术的20岁以上患者的医疗记录。根据手术前1个月内进行的血清氯化物检测结果将患者分组:正常氯血症,97-110mmol·L?1;高氯血症 >110 mmol·L?1,低氯血症<97 mmol·L?1。本研究的主要终点是术前各血清氯化物组术后90天死亡率的差异。次要终点是术前各血清氯化物组术后急性肾损伤发生率的差异。

结  果

最后,共有106505名病人被包括在内(2147被分配至术前低氯血症组及617名被分配至高氯血症组)。多变量Cox回归分析显示,与正常组相比,低氯血症(危害比, 1.46; 95% CI, 1.16–1.84; P = .001)和高氯血症组 (危害比, 1.76; 95%CI, 1.13–2.73; P = .013)的90天死亡率显着增加。此外,多变量logistic回归分析显示,与正常氯血症组相比,术前低氯血症组急性肾损伤的几率增加了1.83倍(odds ratio,1.83;95%,1.53–2.19;p.001)。

结  论

术前低氯血症和高氯血症与非心脏手术后90天死亡率升高有关。此外,术前低氯血症与术后急性肾损伤的风险增加有关。

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createdName=xiangyuzhou971, createdTime=Mon Aug 17 08:53:00 CST 2020, time=2020-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819292, encodeId=8fc218192923b, content=<a href='/topic/show?id=aba89940943' target=_blank style='color:#2F92EE;'>#非心脏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99409, encryptionId=aba89940943, topicName=非心脏)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=917c196, createdName=sjzlzc007, createdTime=Sun Jun 28 08:53:00 CST 2020, time=2020-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819381, encodeId=12ee1819381fc, content=<a href='/topic/show?id=210c9941411' target=_blank style='color:#2F92EE;'>#非心脏手术后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99414, 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channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Thu Jul 23 00:53:00 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1823587, encodeId=db2e182358e6f, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Fri Mar 13 05:53:00 CST 2020, time=2020-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488294, encodeId=ffc714882941c, content=<a 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time=2019-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631005, encodeId=24f7163100563, content=<a href='/topic/show?id=105b610e30f' target=_blank style='color:#2F92EE;'>#术后死亡率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61073, encryptionId=105b610e30f, topicName=术后死亡率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=058c21623844, createdName=jiekemin, createdTime=Sun Dec 08 09:53:00 CST 2019, time=2019-12-08, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1700111, encodeId=7bca1e00111d3, content=<a href='/topic/show?id=295524e541' target=_blank style='color:#2F92EE;'>#Anal#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2475, encryptionId=295524e541, topicName=Anal)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=de3a29999500, createdName=经常头晕, createdTime=Wed Mar 11 02:53:00 CST 2020, time=2020-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2051481, encodeId=1e5e20514811c, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, 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channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Thu Jul 23 00:53:00 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1823587, encodeId=db2e182358e6f, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Fri Mar 13 05:53:00 CST 2020, time=2020-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488294, encodeId=ffc714882941c, content=<a href='/topic/show?id=f37799413a6' target=_blank style='color:#2F92EE;'>#非心脏手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99413, encryptionId=f37799413a6, topicName=非心脏手术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b5438409695, createdName=bnurmamat, createdTime=Sun Dec 08 09:53:00 CST 2019, time=2019-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517669, encodeId=430c151e669aa, content=<a href='/topic/show?id=a8416408096' target=_blank style='color:#2F92EE;'>#氯化物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64080, encryptionId=a8416408096, topicName=氯化物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7c0011104054, createdName=ms1260584454294838, createdTime=Sun Dec 08 09:53:00 CST 2019, time=2019-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631005, encodeId=24f7163100563, content=<a href='/topic/show?id=105b610e30f' target=_blank style='color:#2F92EE;'>#术后死亡率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61073, encryptionId=105b610e30f, topicName=术后死亡率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=058c21623844, createdName=jiekemin, createdTime=Sun Dec 08 09:53:00 CST 2019, time=2019-12-08, status=1, ipAttribution=)]
    2020-05-25 AspirantSuo
  6. [GetPortalCommentsPageByObjectIdResponse(id=1700111, encodeId=7bca1e00111d3, content=<a href='/topic/show?id=295524e541' target=_blank style='color:#2F92EE;'>#Anal#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2475, encryptionId=295524e541, topicName=Anal)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=de3a29999500, createdName=经常头晕, createdTime=Wed Mar 11 02:53:00 CST 2020, time=2020-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2051481, encodeId=1e5e20514811c, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, 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time=2019-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631005, encodeId=24f7163100563, content=<a href='/topic/show?id=105b610e30f' target=_blank style='color:#2F92EE;'>#术后死亡率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61073, encryptionId=105b610e30f, topicName=术后死亡率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=058c21623844, createdName=jiekemin, createdTime=Sun Dec 08 09:53:00 CST 2019, time=2019-12-08, status=1, ipAttribution=)]
  7. 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