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KIDNEY INT:过表达B型钠尿肽可以减轻多囊肾病大鼠的肝肾纤维囊性疾病!

2017-04-15 xing.T MedSci原创

综上所述,该研究的数据表明持续激活鸟苷酸环化酶A对多囊性肾脏和肝脏疾病具有多方面的效应。因此,靶向的鸟苷酸环化酶A-cGMP轴可能为肝脏和肾脏纤维囊性疾病的治疗提供了新策略。

多囊性肾脏病包括渐进性肝脏和肾脏囊肿扩张和纤维化,常常导致终末期肾脏疾病。已有研究证实增加的抗利尿激素和cAMP信号通路、钙平衡失调以及高血压在多囊肾病的进展中起发挥着重要作用。鸟苷酸环化酶激动剂、B型利钠肽(BNP)可以激活cGMP信号通路,并且显示出具有减弱纤维化、抗高血压和抗利尿激素的效应,并且可能会对抗多囊肾病的发病机制。

近日,肾脏病领域权威杂志kidney international上发表了一篇研究文章,在这个研究中,研究人员旨在评估了激活鸟苷酸环化酶A信号通路后对多囊肾病模型大鼠的多囊肾病进展的影响。

研究人员发现持续的BNP可以显著降低肾脏重量、肾脏囊性指标和纤维化,并且与抑制体内肝囊肿形成相一致。在体外实验中,BNP减少囊性上皮细胞增殖,抑制纤维化基因表达,增加细胞内钙离子水平。

综上所述,该研究的数据表明持续激活鸟苷酸环化酶A对多囊性肾脏和肝脏疾病具有多方面的效应。因此,靶向的鸟苷酸环化酶A-cGMP轴可能为肝脏和肾脏纤维囊性疾病的治疗提供了新策略。

原始出处:

Sara J. Holditch, et al. B-type natriuretic peptide overexpression ameliorates hepatorenal fibrocystic disease in a rat model of polycystic kidney disease.kidney-international.2017. http://www.kidney-international.org/article/S0085-2538(17)30150-3/pdf

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    2017-05-08 wolongzxh
  3. 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    2018-01-01 lq1767
  4. 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    2017-04-26 1ddf0692m34(暂无匿称)

    好方法,学习了

    0

  5. 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    2017-04-20 春暖花开8785

    B型钠尿肽对肾囊肿有治疗作用是一个新的发现。

    0

  6. 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createdName=gwc389, createdTime=Mon Apr 17 12:35:00 CST 2017, time=2017-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187905, encodeId=976218e905b4, content=非常好的文章,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Apr 16 12:42:36 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187761, encodeId=ef1218e76150, content=学习过了,很好值得研究!, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Sun Apr 16 00:02:31 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187742, encodeId=545d18e74228, content=学习了,b型钠尿肽对人的囊性疾病有治疗作用吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sat Apr 15 23:34:23 CST 2017, time=2017-04-15, status=1, ipAttribution=)]
    2017-04-17 gwc389
  8. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Sun Apr 16 00:02:31 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187742, encodeId=545d18e74228, content=学习了,b型钠尿肽对人的囊性疾病有治疗作用吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sat Apr 15 23:34:23 CST 2017, time=2017-04-15, status=1, ipAttribution=)]
    2017-04-16 虈亣靌

    非常好的文章,学习了

    0

  9. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Sun Apr 16 00:02:31 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187742, encodeId=545d18e74228, content=学习了,b型钠尿肽对人的囊性疾病有治疗作用吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sat Apr 15 23:34:23 CST 2017, time=2017-04-15, status=1, ipAttribution=)]
    2017-04-16 明天会更好!

    学习过了,很好值得研究!

    0

  10. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Sun Apr 16 00:02:31 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187742, encodeId=545d18e74228, content=学习了,b型钠尿肽对人的囊性疾病有治疗作用吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sat Apr 15 23:34:23 CST 2017, time=2017-04-15, status=1, ipAttribution=)]
    2017-04-15 有备才能无患

    学习了,b型钠尿肽对人的囊性疾病有治疗作用吗?

    0

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