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BMJ:芬太尼是意外死亡率更高的阿片类药物

2018-08-30 zhangfan MedSci原创

研究对近年来与阿片类药物应用相关的死亡事件进行了研究,涉及芬太尼的死亡率有所上升,临床应用过程中因对阿片类导致的不良事件给予额外关注

近日研究人员就处方与非处方阿片类药物应用与阿片相关死亡之间的关系进行了考察。

活动性阿片处方死亡定义为处方给药日期与死亡日期重叠;近期阿片处方定义为死亡前30-180天内配发的处方,研究结果通过年份、性别以及年龄分层。

2013-16年间总计发生2833起阿片类药物导致死亡,活动性阿片处方相对普遍 ,但比例呈下降趋势,由2013年间的38.2%,下降至2016年间的32.5%。老年人和女性是活动性阿片处方死亡的风险人群。2016年活动性阿片处方死亡人群中,45-64岁人群占46%,而24岁以下人群仅占12%。女性阿片类死亡患者中,46%的处于活动性处方期,而男性仅26.4%。活动性阿片处方死亡患者中,37.8%的患者同时服用了处方外阿片类药物。2016年,芬太尼是非处方阿片药物死亡的主要因素,占据41%,而活动性阿片处方死亡患者中芬太尼也是重要因素,2013年芬太尼导致了20%的活动性阿片处方死亡,这一数据到2016年上升至47.5%。

研究对近年来与阿片类药物应用相关的死亡事件进行了研究,涉及芬太尼的死亡率有所上升,临床应用过程中因对阿片类导致的不良事件给予额外关注。

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    2018-12-10 gaoxiaoe
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    2018-09-01 lhlxtx
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    2018-08-30 衣带渐宽

    学习

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