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AIDS 2014:抗癌药能激活休眠HIV病毒

2014-07-24 佚名 生物谷

抗癌药物能唤醒隐藏在病人体内的HIV病毒。研究人员认为,这个发现将为治愈艾滋病提供新方向。 据报道,关于抗癌药物罗米地辛(Romidepsin)的研究结果22日在墨尔本举行的世界艾滋病大会(International AIDS Conference)上公布。研究人员乐观地表示,治愈艾滋病的方法也许会在未来出现。 丹麦奥胡斯大学(Aarhus University)索佳德博士(Ole Schm

抗癌药物能唤醒隐藏在病人体内的HIV病毒。研究人员认为,这个发现将为治愈艾滋病提供新方向。

据报道,关于抗癌药物罗米地辛(Romidepsin)的研究结果22日在墨尔本举行的世界艾滋病大会(International AIDS Conference)上公布。研究人员乐观地表示,治愈艾滋病的方法也许会在未来出现。

丹麦奥胡斯大学(Aarhus University)索佳德博士(Ole Schmeltz Sogaard)是本次研究的主要负责人。HIV能以休眠方式隐藏在CD4细胞中。尽管药物能抑制病人体内的HIV水平,但仍然没有彻底消除HIV病毒的方法。研究人员向6名HIV病人提供抗癌药物,发现抗癌药物能分辨正在休眠的HIV病毒,并让其离开藏身之处。研究人员也发现,对于受到HIV病毒感染的细胞中,抗癌药物能把病毒复制水平提升至正常水平的2至4倍。因此,研究人员能追踪这些细胞。

“我们发现罗米地辛能激活休眠中的HIV病毒,而量的被激活病毒会流进血液。这显示出,我们在治愈艾滋病的路途上踏出了正确一步,但路依然漫长,障碍依然很多。”索佳德博士说。

加利福尼亚大学(University of California)研究人员迪克斯(Steve Deeks)表示,丹麦方面的发现具有重大意义。“至少在我看来,这是第一个能发现隐藏HIV病毒及让其离开藏身之处的明确证据。下一个研究步骤将是如何杀死这些病毒。”

HIV研究人员希望通过激活休眠细胞,并利用现有的治疗方法或试验中的疫苗来消除这些有害细胞。

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    2015-04-01 yese
  2. [GetPortalCommentsPageByObjectIdResponse(id=1668053, encodeId=47e71668053a1, content=<a href='/topic/show?id=902125e1351' target=_blank style='color:#2F92EE;'>#休眠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25713, encryptionId=902125e1351, topicName=休眠)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=34e226239625, createdName=yese, createdTime=Wed Apr 01 01:17:00 CST 2015, time=2015-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2033807, encodeId=c11b203380e8d, content=<a href='/topic/show?id=852b216824' target=_blank style='color:#2F92EE;'>#AID#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2168, encryptionId=852b216824, topicName=AID)], attachment=null, authenticateStatus=null, createdAvatar=/img/user_icon.png, createdBy=1072181, createdName=wjywjy, createdTime=Sat Feb 07 03:17:00 CST 2015, time=2015-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314611, encodeId=c6ae13146117e, content=<a href='/topic/show?id=9d4b5554131' target=_blank style='color:#2F92EE;'>#抗癌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55541, encryptionId=9d4b5554131, topicName=抗癌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sat Jul 26 00:17:00 CST 2014, time=2014-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1365601, encodeId=eda113656016a, content=<a href='/topic/show?id=41fa21e036' target=_blank style='color:#2F92EE;'>#AIDS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2170, encryptionId=41fa21e036, topicName=AIDS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cbcc223, createdName=cooco, createdTime=Sat Jul 26 00:17:00 CST 2014, time=2014-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1412612, encodeId=8b26141261270, content=<a href='/topic/show?id=32ec89220b' target=_blank style='color:#2F92EE;'>#HIV病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8922, encryptionId=32ec89220b, topicName=HIV病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fa102876871, createdName=tigerlr99, createdTime=Sat Jul 26 00:17:00 CST 2014, time=2014-07-26, status=1, ipAttribution=)]
    2015-02-07 wjywjy
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    2014-07-26 sunylz
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    2014-07-26 cooco
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