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CELL:益生菌真的有益肠道健康吗?

2018-09-09 海北 MedSci原创

最近,来自魏茨曼科学研究所的研究人员探究了多菌株益生菌或自体粪便微生物组移植(aFMT)对小鼠和人类粘膜微生物群微环境的抗生素后重建的影响。

益生菌广泛用于预防抗生素相关的生态失调和不良反应。然而,使用抗生素后,益生菌对肠粘膜宿主-微生物体微环境的重建的影响仍然是难以捉摸的。
最近,来自魏茨曼科学研究所的研究人员探究了多菌株益生菌或自体粪便微生物组移植(aFMT)对小鼠和人类粘膜微生物群微环境的抗生素后重建的影响。
与体内平衡相反,抗生素扰动增强了人粘膜中的益生菌定植,但仅在小鼠中轻度改善了定植。与自发性抗生素后恢复相比,益生菌诱导显着延迟,并导致持续不完整的粘膜微生物组重建,以及宿主转录组向稳态的恢复,而aFMT在给药期间能够诱导快速且接近完全的恢复。
在体外,乳酸杆菌分泌的可溶性因子促成益生菌诱导的微生物组抑制。
总体而言,使用抗生素后,潜在的益生菌益处可能被肠道粘膜恢复受损所抵消。因此,我们需要开发一种FMT或个性化益生菌方法,实现粘膜保护,而不影响抗生素扰动宿主中的微生物组重新定殖。

原始出处:

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    2019-02-05 维他命
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    2018-09-11 一天没事干

    很好的学习机会

    0

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    2018-09-09 183****7028

    学习

    0

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    2018-09-09 明月清辉

    谢谢分享,学习了

    0

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