Baidu
map

CGH:恶病质在肝细胞癌患者中普遍存在并与更差的预后相关

2022-05-08 xuyihan MedSci原创

肝细胞癌是原发性肝癌中的一种,原发性肝癌主要包括肝细胞性肝癌、胆管细胞性肝癌和混合性肝癌。

肝细胞癌(HCC)是美国癌症相关死亡中上升最快的。最常用的HCC分期系统--巴塞罗那诊所肝癌(BCLC)分期系统--不仅包括病人的肿瘤负担,还包括他们的肝功能障碍程度和表现状况。先前的研究已经证明了肌肉疏松症和功能状态对HCC生存的影响。同时,虚弱程度已成为肝硬化患者预后的重要预测因素。越来越多的人利用患者的表现状态和虚弱程度来进行预后和治疗决策的判断。癌症恶病质是一种临床消瘦综合征,其特征是脂肪组织和骨骼肌质量的持续损失,导致渐进性的功能障碍。

恶病质的机制是多因素的,不仅与热量缺乏有关,而且部分是由全身性炎症和肿瘤分泌的因素导致的代谢异常所驱动。它被认为是一个连续的过程,有三个临床阶段(恶性肿瘤前期、恶性肿瘤和难治性恶性肿瘤)。恶病质很常见,大约50%的癌症患者会出现恶病质。然而,关于肝细胞癌 (HCC) 患者恶病质的患病率和临床意义的数据有限。

研究人员对2008年至2018年期间被诊断为HCC的患者进行了一项回顾性队列研究。研究人员在患者HCC诊断前 6 个月和诊断时记录了患者体重。恶病质定义为体重减轻>5%(或体重指数<20 kg/m2时体重减轻>2% ),恶病质前期定义为体重减轻2%至5%。然后使用多变量逻辑回归模型来确定恶病质的相关性,并使用多变量 Cox 比例风险模型来确定与总生存期相关的因素。

 

在604例 HCC 患者中,201 例(33.3%)处于恶病质前期,143 例(23.7%)在诊断时有恶病质,其中巴塞罗那诊所肝癌 0/A期、B期,C期和D期患者分别为 19.0%、23.5%、34.7% 和 34.0%。恶病质患者接受 HCC 治疗的可能性较小(OR,0.38;95%CI,0.21-0.71),并且与恶病质前期或体重稳定的患者相比,生存期更差(11.3 个月 vs 20.4 个月 vs 23.5 个月;P < .001 )。在调整年龄、性别、种族、民族、Child Pugh 分级、甲胎蛋白、巴塞罗那临床肝癌分期和 HCC 治疗后,恶病质仍然与较差的生存率独立相关(OR,1.43;95%CI,1.11-1.84)。

本项研究证实近四分之一的 HCC 患者出现恶病质,包括许多代偿期肝硬化或早期肿瘤。与癌症相关的体重减轻似乎是 HCC 患者预后较差的早期独立预测因素。

原始出处:

Nicole E. Rich. Et al. Cachexia is Prevalent in Patients With Hepatocellular Carcinoma and Associated With Worse Prognosis. Clinical Gastroenterology and Hepatology.2022.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (7)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1979331, encodeId=920719e933136, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Tue Jul 12 04:52:43 CST 2022, time=2022-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1693094, encodeId=10061693094b1, content=<a href='/topic/show?id=f07d529e6ca' target=_blank style='color:#2F92EE;'>#恶病质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52976, encryptionId=f07d529e6ca, topicName=恶病质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3cd929335736, createdName=wincls, createdTime=Tue Sep 27 13:52:43 CST 2022, time=2022-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863668, encodeId=6960186366821, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Wed Mar 22 05:52:43 CST 2023, time=2023-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1229307, encodeId=c437122930ea4, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=37a26588465, createdName=ms9000000386850634, createdTime=Tue Jun 28 23:33:54 CST 2022, time=2022-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2058377, encodeId=fd8c20583e755, content=<a href='/topic/show?id=f6ba4546d1' target=_blank style='color:#2F92EE;'>#CGH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4546, encryptionId=f6ba4546d1, topicName=CGH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8994206, createdName=chendoc242, createdTime=Mon Jul 11 10:52:43 CST 2022, time=2022-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1218116, encodeId=9c6e1218116cf, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2020/02/15/7274ed1be4747d648e4e2f7f62fae403.jpg, createdBy=d8d65273314, createdName=1482963am12暂无昵称, createdTime=Mon May 09 12:32:57 CST 2022, time=2022-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1217998, encodeId=dbda121e99859, content=<a href='/topic/show?id=aa0582e6946' target=_blank style='color:#2F92EE;'>#肿瘤#</a>哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82769, encryptionId=aa0582e6946, topicName=肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b8ba6319857, createdName=1064510_1039, createdTime=Mon May 09 07:58:47 CST 2022, time=2022-05-09, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1979331, encodeId=920719e933136, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Tue Jul 12 04:52:43 CST 2022, time=2022-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1693094, encodeId=10061693094b1, content=<a href='/topic/show?id=f07d529e6ca' target=_blank style='color:#2F92EE;'>#恶病质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52976, encryptionId=f07d529e6ca, topicName=恶病质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3cd929335736, createdName=wincls, createdTime=Tue Sep 27 13:52:43 CST 2022, time=2022-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863668, encodeId=6960186366821, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Wed Mar 22 05:52:43 CST 2023, time=2023-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1229307, encodeId=c437122930ea4, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=37a26588465, createdName=ms9000000386850634, createdTime=Tue Jun 28 23:33:54 CST 2022, time=2022-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2058377, encodeId=fd8c20583e755, content=<a href='/topic/show?id=f6ba4546d1' target=_blank style='color:#2F92EE;'>#CGH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4546, encryptionId=f6ba4546d1, topicName=CGH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8994206, createdName=chendoc242, createdTime=Mon Jul 11 10:52:43 CST 2022, time=2022-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1218116, encodeId=9c6e1218116cf, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2020/02/15/7274ed1be4747d648e4e2f7f62fae403.jpg, createdBy=d8d65273314, createdName=1482963am12暂无昵称, createdTime=Mon May 09 12:32:57 CST 2022, time=2022-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1217998, encodeId=dbda121e99859, content=<a href='/topic/show?id=aa0582e6946' target=_blank style='color:#2F92EE;'>#肿瘤#</a>哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82769, encryptionId=aa0582e6946, topicName=肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b8ba6319857, createdName=1064510_1039, createdTime=Mon May 09 07:58:47 CST 2022, time=2022-05-09, status=1, ipAttribution=)]
    2022-09-27 wincls
  3. [GetPortalCommentsPageByObjectIdResponse(id=1979331, encodeId=920719e933136, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Tue Jul 12 04:52:43 CST 2022, time=2022-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1693094, encodeId=10061693094b1, content=<a href='/topic/show?id=f07d529e6ca' target=_blank style='color:#2F92EE;'>#恶病质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52976, encryptionId=f07d529e6ca, topicName=恶病质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3cd929335736, createdName=wincls, createdTime=Tue Sep 27 13:52:43 CST 2022, time=2022-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863668, encodeId=6960186366821, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Wed Mar 22 05:52:43 CST 2023, time=2023-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1229307, encodeId=c437122930ea4, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=37a26588465, createdName=ms9000000386850634, createdTime=Tue Jun 28 23:33:54 CST 2022, time=2022-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2058377, encodeId=fd8c20583e755, content=<a href='/topic/show?id=f6ba4546d1' target=_blank style='color:#2F92EE;'>#CGH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4546, encryptionId=f6ba4546d1, topicName=CGH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8994206, createdName=chendoc242, createdTime=Mon Jul 11 10:52:43 CST 2022, time=2022-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1218116, encodeId=9c6e1218116cf, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2020/02/15/7274ed1be4747d648e4e2f7f62fae403.jpg, createdBy=d8d65273314, createdName=1482963am12暂无昵称, createdTime=Mon May 09 12:32:57 CST 2022, time=2022-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1217998, encodeId=dbda121e99859, content=<a href='/topic/show?id=aa0582e6946' target=_blank style='color:#2F92EE;'>#肿瘤#</a>哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82769, encryptionId=aa0582e6946, topicName=肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b8ba6319857, createdName=1064510_1039, createdTime=Mon May 09 07:58:47 CST 2022, time=2022-05-09, status=1, ipAttribution=)]
    2023-03-22 xjy02
  4. [GetPortalCommentsPageByObjectIdResponse(id=1979331, encodeId=920719e933136, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Tue Jul 12 04:52:43 CST 2022, time=2022-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1693094, encodeId=10061693094b1, content=<a href='/topic/show?id=f07d529e6ca' target=_blank style='color:#2F92EE;'>#恶病质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52976, encryptionId=f07d529e6ca, topicName=恶病质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3cd929335736, createdName=wincls, createdTime=Tue Sep 27 13:52:43 CST 2022, time=2022-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863668, encodeId=6960186366821, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Wed Mar 22 05:52:43 CST 2023, time=2023-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1229307, encodeId=c437122930ea4, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=37a26588465, createdName=ms9000000386850634, createdTime=Tue Jun 28 23:33:54 CST 2022, time=2022-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2058377, encodeId=fd8c20583e755, content=<a href='/topic/show?id=f6ba4546d1' target=_blank style='color:#2F92EE;'>#CGH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4546, encryptionId=f6ba4546d1, topicName=CGH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8994206, createdName=chendoc242, createdTime=Mon Jul 11 10:52:43 CST 2022, time=2022-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1218116, encodeId=9c6e1218116cf, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2020/02/15/7274ed1be4747d648e4e2f7f62fae403.jpg, createdBy=d8d65273314, createdName=1482963am12暂无昵称, createdTime=Mon May 09 12:32:57 CST 2022, time=2022-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1217998, encodeId=dbda121e99859, content=<a href='/topic/show?id=aa0582e6946' target=_blank style='color:#2F92EE;'>#肿瘤#</a>哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82769, encryptionId=aa0582e6946, topicName=肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b8ba6319857, createdName=1064510_1039, createdTime=Mon May 09 07:58:47 CST 2022, time=2022-05-09, status=1, ipAttribution=)]
    2022-06-28 ms9000000386850634

    学习学习

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1979331, encodeId=920719e933136, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Tue Jul 12 04:52:43 CST 2022, time=2022-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1693094, encodeId=10061693094b1, content=<a href='/topic/show?id=f07d529e6ca' target=_blank style='color:#2F92EE;'>#恶病质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52976, encryptionId=f07d529e6ca, topicName=恶病质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3cd929335736, createdName=wincls, createdTime=Tue Sep 27 13:52:43 CST 2022, time=2022-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863668, encodeId=6960186366821, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Wed Mar 22 05:52:43 CST 2023, time=2023-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1229307, encodeId=c437122930ea4, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=37a26588465, createdName=ms9000000386850634, createdTime=Tue Jun 28 23:33:54 CST 2022, time=2022-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2058377, encodeId=fd8c20583e755, content=<a href='/topic/show?id=f6ba4546d1' target=_blank style='color:#2F92EE;'>#CGH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4546, encryptionId=f6ba4546d1, topicName=CGH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8994206, createdName=chendoc242, createdTime=Mon Jul 11 10:52:43 CST 2022, time=2022-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1218116, encodeId=9c6e1218116cf, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2020/02/15/7274ed1be4747d648e4e2f7f62fae403.jpg, createdBy=d8d65273314, createdName=1482963am12暂无昵称, createdTime=Mon May 09 12:32:57 CST 2022, time=2022-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1217998, encodeId=dbda121e99859, content=<a href='/topic/show?id=aa0582e6946' target=_blank style='color:#2F92EE;'>#肿瘤#</a>哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82769, encryptionId=aa0582e6946, topicName=肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b8ba6319857, createdName=1064510_1039, createdTime=Mon May 09 07:58:47 CST 2022, time=2022-05-09, status=1, ipAttribution=)]
    2022-07-11 chendoc242
  6. [GetPortalCommentsPageByObjectIdResponse(id=1979331, encodeId=920719e933136, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Tue Jul 12 04:52:43 CST 2022, time=2022-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1693094, encodeId=10061693094b1, content=<a href='/topic/show?id=f07d529e6ca' target=_blank style='color:#2F92EE;'>#恶病质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52976, encryptionId=f07d529e6ca, topicName=恶病质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3cd929335736, createdName=wincls, createdTime=Tue Sep 27 13:52:43 CST 2022, time=2022-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863668, encodeId=6960186366821, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Wed Mar 22 05:52:43 CST 2023, time=2023-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1229307, encodeId=c437122930ea4, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=37a26588465, createdName=ms9000000386850634, createdTime=Tue Jun 28 23:33:54 CST 2022, time=2022-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2058377, encodeId=fd8c20583e755, content=<a href='/topic/show?id=f6ba4546d1' target=_blank style='color:#2F92EE;'>#CGH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4546, encryptionId=f6ba4546d1, topicName=CGH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8994206, createdName=chendoc242, createdTime=Mon Jul 11 10:52:43 CST 2022, time=2022-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1218116, encodeId=9c6e1218116cf, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2020/02/15/7274ed1be4747d648e4e2f7f62fae403.jpg, createdBy=d8d65273314, createdName=1482963am12暂无昵称, createdTime=Mon May 09 12:32:57 CST 2022, time=2022-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1217998, encodeId=dbda121e99859, content=<a href='/topic/show?id=aa0582e6946' target=_blank style='color:#2F92EE;'>#肿瘤#</a>哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82769, encryptionId=aa0582e6946, topicName=肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b8ba6319857, createdName=1064510_1039, createdTime=Mon May 09 07:58:47 CST 2022, time=2022-05-09, status=1, ipAttribution=)]
    2022-05-09 1482963am12暂无昵称

    学习了

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1979331, encodeId=920719e933136, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Tue Jul 12 04:52:43 CST 2022, time=2022-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1693094, encodeId=10061693094b1, content=<a href='/topic/show?id=f07d529e6ca' target=_blank style='color:#2F92EE;'>#恶病质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52976, encryptionId=f07d529e6ca, topicName=恶病质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3cd929335736, createdName=wincls, createdTime=Tue Sep 27 13:52:43 CST 2022, time=2022-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863668, encodeId=6960186366821, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Wed Mar 22 05:52:43 CST 2023, time=2023-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1229307, encodeId=c437122930ea4, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=37a26588465, createdName=ms9000000386850634, createdTime=Tue Jun 28 23:33:54 CST 2022, time=2022-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2058377, encodeId=fd8c20583e755, content=<a href='/topic/show?id=f6ba4546d1' target=_blank style='color:#2F92EE;'>#CGH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4546, encryptionId=f6ba4546d1, topicName=CGH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8994206, createdName=chendoc242, createdTime=Mon Jul 11 10:52:43 CST 2022, time=2022-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1218116, encodeId=9c6e1218116cf, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2020/02/15/7274ed1be4747d648e4e2f7f62fae403.jpg, createdBy=d8d65273314, createdName=1482963am12暂无昵称, createdTime=Mon May 09 12:32:57 CST 2022, time=2022-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1217998, encodeId=dbda121e99859, content=<a href='/topic/show?id=aa0582e6946' target=_blank style='color:#2F92EE;'>#肿瘤#</a>哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82769, encryptionId=aa0582e6946, topicName=肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b8ba6319857, createdName=1064510_1039, createdTime=Mon May 09 07:58:47 CST 2022, time=2022-05-09, status=1, ipAttribution=)]
    2022-05-09 1064510_1039

相关资讯

BMC Cancer:仑伐替尼联合PD-1抑制剂治疗晚期肝细胞癌的真实世界疗效

研究表明,仑伐替尼联合PD-1抑制剂可为晚期HCC伴有Vp4患者带来生存获益。

Clin Cancer Res:派姆单抗单药治疗初治晚期肝细胞癌

派姆单抗治疗可为初治晚期肝细胞癌患者提供持久的抗肿瘤活性、可期的总生存期

Clin Cancer Res:甲胎蛋白可作为肝细胞癌采用Atezolizuma+贝伐单抗治疗的预后生物标志物

治疗第6周时的AFP反应可作为受Atezolizuma+贝伐单抗治疗的肝细胞癌患者预后的替代生物标志物

European Radiology:热消融在肝细胞癌治疗中的价值

本研究发现,TA对原发性和复发性HCC都是一种有效的治疗方式。虽然许多患者在随访过程中出现复发,但本研究证明,大多数患者可以通过重复TA进行治疗以缓解病情。

Clin Cancer Res:Pembrolizumab单药治疗晚期肝细胞癌的效果

派姆单抗单药治疗可晚期肝细胞癌患者提供持久的抗肿瘤活性

Clin Cancer Res:可预测晚期肝癌患者采用信迪利单抗+IBI305治疗预后的生物标志物

血清CD137水平和肿瘤基质M1巨噬细胞密度可预测晚期肝癌患者采用信迪利单抗+IBI305治疗的预后

Baidu
map
Baidu
map
Baidu
map