Baidu
map

eLife:震撼推出5篇重复性研究,直指**研究可重复性差

2017-01-20 BioArt BioArt

1月19日,eLife杂志在线出版了5篇研究论文,这些研究直指过去几年里肿瘤生物学领域广受瞩目的部分研究成果的可重复性非常差。 背景介绍: 2013年,一位名叫Elizabeth Iorns的80后女性肿瘤生物学家(University of Miami Miller School of Medicine助理教授)发起了一项“癌症生物领域重复性工程”(Reproducibility

1月19日,eLife杂志在线出版了5篇研究论文,这些研究直指过去几年里肿瘤生物学领域广受瞩目的部分研究成果的可重复性非常差。

实际上,在此前,eLife上已提前说明对此5篇文章进行重复性研究,并做了Registered report,以示更为客观公正。结果是令人遗憾的,可重复性很不理想。

背景介绍:

2013年,一位名叫Elizabeth Iorns的80后女性肿瘤生物学家(University of Miami Miller School of Medicine助理教授)发起了一项“癌症生物领域重复性工程”(Reproducibility Project: Cancer Biology ),该工程旨在挑选出2010年至2012年间50篇高影响力的肿瘤生物学相关研究论文,验证这些论文的可重复性(目前由于资金的原因,50篇论文缩减到30篇)。该项工程主要由Elizabeth Iorns创办的Science Exchange (一个科学实验外包平台)联合 Center for Open Science(科学开放中心)完成。

2010到2012年三年中每一年选取用于重复验证的排名前三的研究(来源:2015,The Cancer Test,Science)

2015年,Science杂志以“The Cancer Test”为题专文报道了“癌症生物领域重复性工程”的由来和设立的背景,其中特别提到一个主要原因可能是因为一些制药公司巨头在重复CNS等顶级杂志中发表的肿瘤相关论文时发现可重复性非常低(Amgen公司的数据表明,53篇顶级肿瘤研究论文只有6篇可以重复;Bayer公司的数据表明有79%的重复失败率)。由于公司和相关实验室签订了保密协议而不能公布他们无法重复的研究,这使得公司显得很被动。

如今,将近3年的时间过去了,eLife终于发布了第一阶段5篇重复性实验的结果,结果十分令人遗憾,无一例外都表示被挑选的这些论文论文的可重复性非常差。这5篇论文如下(分别源自Cell,Nature,Science,PNAS和Sci Trans Med):

为了增加重复项目的严谨性,项目负责人在实验开始前联系被选中进行重复试验的一些论文的作者,查阅了相关的原始数据,项目组还和有关学校签订了细胞、质粒和小鼠等实验资源转移协议,最终将专家审核过的实验方案发布在eLife杂志上。

5篇被选中的论文

第一篇(Cell,2011,谷歌学术引用1051次):

该项研究部分关键试验能被很好的重复,但是在在小鼠荷瘤实验中部分结果尽管和此前报道的结果相似,但是没有显着的统计学意义。

第二篇(Nature,2012,谷歌学术引用422次):

Nature这篇文章通过测序手段鉴定到了一个与黑色素瘤发生相关的基因PREX2突变,并且在体内的过表达实验中显示过表达关键点突变的PREX2能促进肿瘤发生率(下图右)。而eLife这篇重复性的研究表明,过表达野生型的PREX2和突变的PREX2对肿瘤生长没有影响(下图左)。令人惊讶的是,相较于对照组,Nature文章中70%小鼠的中位无瘤生存期都在9周以后,而eLife重复性实验中的小鼠的中位无瘤生存期都只有一周左右。

第三篇(Science,2010,谷歌学术引用493次):

2010年发表的这项研究成果主要是发现了一种称为iRGD的小肽可以协助抗肿瘤药物渗透到坚韧的肿瘤组织中,从而提高肿瘤药物的治疗效果,而且该小肽不会增加对正常细胞的毒性。然而eLife上报道的这项重复性研究中并没有发现iRGD上述这些作用。

第四篇(Sci Trans Med,2011,谷歌学术引用331次):

2011年的研究中生成发现了一种可以用于治疗肺癌的药物Cimetidine,然而eLife的这项重复性研究中并没有看到Cimetidine在治疗小鼠肺癌的模型中有统计学意义。

第五篇(PNAS,2012,谷歌学术引用288次):

PNAS这项研究声称发现CD47可以作为一个肿瘤治疗的靶点,用针对CD47的抗体治疗可以有效地抑制肿瘤生长。然而,在eLife的这项重复性研究中,用抗IgG抗体作对照,并没有看到用CD47抗体能够有效地治疗肿瘤。

总的来说,上述5项重复试验中,只有第一篇文章的重复性稍微好一些,尽管很多地方也是不尽如人意,而其它4篇文章的肿瘤相关实验中可重复性极差,几乎可以判定为那些所谓新开发的药物或者新鉴定到的靶点并没有起到很明显的作用。结果令人沮丧,尽管此前这些文章在发表之时引起一时的轰动或者很多制药公司的关注。高影响力的论文如此差的重复性确实令人担忧,但是这个项目背后也引起了不少当事科学家的质疑,对很多科学家来说,最大的担忧恐怕是这些承担重复性工程的相关实验室的专业程度,而且可能还有其他公司利益上的考量。另外值得考虑的一点就是,如果仅仅把实验方案提供给外包的实验平台就能解决问题,那么问题来了,科学家还需要花费巨大的精力和时间在实验上吗?

eLife这5篇文章只是目前生物医学领域论文验证重复性的一个开端,是好是坏现在难以评估,后续应该会有20多篇文章会被陆续重复并且发布结果,等此时告一段落,或许学术界会有自己的一个判定。让我们拭目以待吧。

参考文献:

1、B.A.Nosek and T.M. Errington, “Making sense of replications,”eLife, doi:10.7554/eLife.23383.001, 2017.
2、F.Aird et al., “Replication Study:Replication Study: BET bromodomain inhibition as a therapeutic strategy to target c-Myc,” eLife, 6:e21253, 2017.

3、S.Horrigan et al., “Replication Study: Melanoma genome sequencing reveals frequent PREX2mutations,” eLife, 6:e21634,2017.

4、S.Horrigan et al.,Replication Study: The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors, eLife, 6:e18173,2017.

5、I.Kandela et al.,Replication Study: Discovery and preclinical validation of drug indications using compendia of public gene expression data eLife, 6:e17044,2017

6、C. Mantis et al., Replication Study: Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs eLife, 6:e17584, 2017.

7.The Cancer Test. Science,2016

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (12)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1751552, encodeId=8f091e5155222, content=<a href='/topic/show?id=713d95e399f' target=_blank style='color:#2F92EE;'>#重复性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95739, encryptionId=713d95e399f, topicName=重复性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ced636322728, createdName=珙桐, createdTime=Mon Jul 10 00:45:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1972985, encodeId=e6a119e2985d6, content=<a href='/topic/show?id=72d566e3a6' target=_blank style='color:#2F92EE;'>#eLife#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6673, encryptionId=72d566e3a6, topicName=eLife)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Sun May 14 15:45:00 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=176157, encodeId=2f431e61574f, content=只能呵呵了, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=071c2012037, createdName=wmu姿, createdTime=Tue Feb 14 19:46:12 CST 2017, time=2017-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=172830, encodeId=16931e28306c, content=其实也是有能重复出来的研究的, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=071c2012037, createdName=wmu姿, createdTime=Fri Jan 27 08:47:47 CST 2017, time=2017-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068486, encodeId=fe342068486cd, content=<a href='/topic/show?id=59371088215' target=_blank style='color:#2F92EE;'>#Life#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10882, encryptionId=59371088215, topicName=Life)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Thu May 11 23:45:00 CST 2017, time=2017-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171806, encodeId=c7b41e1806ec, content=这几篇顶级文章没有中国人的,如果选择中国人的文章,结果会如何?, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jan 21 11:56:02 CST 2017, time=2017-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171805, encodeId=c10f1e1805ac, content=很多实验是第三方公司做的,结果完全根据需要而产生!, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jan 21 11:55:18 CST 2017, time=2017-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171629, encodeId=94061e162907, content=飘过,围观, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuHfSLw3PzIKiaSnTBUuAtRkrrxWpibukl35iciaGtBq4LYQv4ian1tPC3IdmzWI2dZ3cDC8wUg5CnBxlJ/0, createdBy=33a51675735, createdName=jiangxianchen, createdTime=Fri Jan 20 16:47:17 CST 2017, time=2017-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171628, encodeId=b5801e162858, content=天下乌鸦一样啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fb8a1655102, createdName=米2301, createdTime=Fri Jan 20 16:40:16 CST 2017, time=2017-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171613, encodeId=a3271e161367, content=觉得发的优秀的文章,本身就应该要有重复性,才更有说服力,然而...?, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0761981653, createdName=Ailyre, createdTime=Fri Jan 20 15:23:45 CST 2017, time=2017-01-20, status=1, ipAttribution=)]
    2017-07-10 珙桐
  2. [GetPortalCommentsPageByObjectIdResponse(id=1751552, encodeId=8f091e5155222, content=<a href='/topic/show?id=713d95e399f' target=_blank style='color:#2F92EE;'>#重复性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95739, encryptionId=713d95e399f, topicName=重复性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ced636322728, createdName=珙桐, createdTime=Mon Jul 10 00:45:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1972985, encodeId=e6a119e2985d6, content=<a href='/topic/show?id=72d566e3a6' target=_blank style='color:#2F92EE;'>#eLife#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6673, encryptionId=72d566e3a6, topicName=eLife)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Sun May 14 15:45:00 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=176157, encodeId=2f431e61574f, content=只能呵呵了, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=071c2012037, createdName=wmu姿, createdTime=Tue Feb 14 19:46:12 CST 2017, time=2017-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=172830, encodeId=16931e28306c, content=其实也是有能重复出来的研究的, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=071c2012037, createdName=wmu姿, createdTime=Fri Jan 27 08:47:47 CST 2017, time=2017-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068486, encodeId=fe342068486cd, content=<a href='/topic/show?id=59371088215' target=_blank style='color:#2F92EE;'>#Life#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10882, encryptionId=59371088215, topicName=Life)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Thu May 11 23:45:00 CST 2017, time=2017-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171806, encodeId=c7b41e1806ec, content=这几篇顶级文章没有中国人的,如果选择中国人的文章,结果会如何?, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jan 21 11:56:02 CST 2017, time=2017-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171805, encodeId=c10f1e1805ac, content=很多实验是第三方公司做的,结果完全根据需要而产生!, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jan 21 11:55:18 CST 2017, time=2017-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171629, encodeId=94061e162907, content=飘过,围观, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuHfSLw3PzIKiaSnTBUuAtRkrrxWpibukl35iciaGtBq4LYQv4ian1tPC3IdmzWI2dZ3cDC8wUg5CnBxlJ/0, createdBy=33a51675735, createdName=jiangxianchen, createdTime=Fri Jan 20 16:47:17 CST 2017, time=2017-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171628, encodeId=b5801e162858, content=天下乌鸦一样啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fb8a1655102, createdName=米2301, createdTime=Fri Jan 20 16:40:16 CST 2017, time=2017-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171613, encodeId=a3271e161367, content=觉得发的优秀的文章,本身就应该要有重复性,才更有说服力,然而...?, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0761981653, createdName=Ailyre, createdTime=Fri Jan 20 15:23:45 CST 2017, time=2017-01-20, status=1, ipAttribution=)]
    2017-05-14 膀胱癌
  3. [GetPortalCommentsPageByObjectIdResponse(id=1751552, encodeId=8f091e5155222, content=<a href='/topic/show?id=713d95e399f' target=_blank style='color:#2F92EE;'>#重复性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95739, encryptionId=713d95e399f, topicName=重复性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ced636322728, createdName=珙桐, createdTime=Mon Jul 10 00:45:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1972985, encodeId=e6a119e2985d6, content=<a href='/topic/show?id=72d566e3a6' target=_blank style='color:#2F92EE;'>#eLife#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6673, encryptionId=72d566e3a6, topicName=eLife)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Sun May 14 15:45:00 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=176157, encodeId=2f431e61574f, content=只能呵呵了, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=071c2012037, createdName=wmu姿, createdTime=Tue Feb 14 19:46:12 CST 2017, time=2017-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=172830, encodeId=16931e28306c, content=其实也是有能重复出来的研究的, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=071c2012037, createdName=wmu姿, createdTime=Fri Jan 27 08:47:47 CST 2017, time=2017-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068486, encodeId=fe342068486cd, content=<a href='/topic/show?id=59371088215' target=_blank style='color:#2F92EE;'>#Life#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10882, encryptionId=59371088215, topicName=Life)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Thu May 11 23:45:00 CST 2017, time=2017-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171806, encodeId=c7b41e1806ec, content=这几篇顶级文章没有中国人的,如果选择中国人的文章,结果会如何?, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jan 21 11:56:02 CST 2017, time=2017-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171805, encodeId=c10f1e1805ac, content=很多实验是第三方公司做的,结果完全根据需要而产生!, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jan 21 11:55:18 CST 2017, time=2017-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171629, encodeId=94061e162907, content=飘过,围观, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuHfSLw3PzIKiaSnTBUuAtRkrrxWpibukl35iciaGtBq4LYQv4ian1tPC3IdmzWI2dZ3cDC8wUg5CnBxlJ/0, createdBy=33a51675735, createdName=jiangxianchen, createdTime=Fri Jan 20 16:47:17 CST 2017, time=2017-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171628, encodeId=b5801e162858, content=天下乌鸦一样啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fb8a1655102, createdName=米2301, createdTime=Fri Jan 20 16:40:16 CST 2017, time=2017-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171613, encodeId=a3271e161367, content=觉得发的优秀的文章,本身就应该要有重复性,才更有说服力,然而...?, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0761981653, createdName=Ailyre, createdTime=Fri Jan 20 15:23:45 CST 2017, time=2017-01-20, status=1, ipAttribution=)]
    2017-02-14 wmu姿

    只能呵呵了

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1751552, encodeId=8f091e5155222, content=<a href='/topic/show?id=713d95e399f' target=_blank style='color:#2F92EE;'>#重复性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95739, encryptionId=713d95e399f, topicName=重复性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ced636322728, createdName=珙桐, createdTime=Mon Jul 10 00:45:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1972985, encodeId=e6a119e2985d6, content=<a href='/topic/show?id=72d566e3a6' target=_blank style='color:#2F92EE;'>#eLife#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6673, encryptionId=72d566e3a6, topicName=eLife)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Sun May 14 15:45:00 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=176157, encodeId=2f431e61574f, content=只能呵呵了, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=071c2012037, createdName=wmu姿, createdTime=Tue Feb 14 19:46:12 CST 2017, time=2017-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=172830, encodeId=16931e28306c, content=其实也是有能重复出来的研究的, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=071c2012037, createdName=wmu姿, createdTime=Fri Jan 27 08:47:47 CST 2017, time=2017-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068486, encodeId=fe342068486cd, content=<a href='/topic/show?id=59371088215' target=_blank style='color:#2F92EE;'>#Life#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10882, encryptionId=59371088215, topicName=Life)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Thu May 11 23:45:00 CST 2017, time=2017-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171806, encodeId=c7b41e1806ec, content=这几篇顶级文章没有中国人的,如果选择中国人的文章,结果会如何?, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jan 21 11:56:02 CST 2017, time=2017-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171805, encodeId=c10f1e1805ac, content=很多实验是第三方公司做的,结果完全根据需要而产生!, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jan 21 11:55:18 CST 2017, time=2017-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171629, encodeId=94061e162907, content=飘过,围观, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuHfSLw3PzIKiaSnTBUuAtRkrrxWpibukl35iciaGtBq4LYQv4ian1tPC3IdmzWI2dZ3cDC8wUg5CnBxlJ/0, createdBy=33a51675735, createdName=jiangxianchen, createdTime=Fri Jan 20 16:47:17 CST 2017, time=2017-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171628, encodeId=b5801e162858, content=天下乌鸦一样啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fb8a1655102, createdName=米2301, createdTime=Fri Jan 20 16:40:16 CST 2017, time=2017-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171613, encodeId=a3271e161367, content=觉得发的优秀的文章,本身就应该要有重复性,才更有说服力,然而...?, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0761981653, createdName=Ailyre, createdTime=Fri Jan 20 15:23:45 CST 2017, time=2017-01-20, status=1, ipAttribution=)]
    2017-01-27 wmu姿

    其实也是有能重复出来的研究的

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1751552, encodeId=8f091e5155222, content=<a href='/topic/show?id=713d95e399f' target=_blank style='color:#2F92EE;'>#重复性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95739, encryptionId=713d95e399f, topicName=重复性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ced636322728, createdName=珙桐, createdTime=Mon Jul 10 00:45:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1972985, encodeId=e6a119e2985d6, content=<a href='/topic/show?id=72d566e3a6' target=_blank style='color:#2F92EE;'>#eLife#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6673, encryptionId=72d566e3a6, topicName=eLife)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Sun May 14 15:45:00 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=176157, encodeId=2f431e61574f, content=只能呵呵了, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=071c2012037, createdName=wmu姿, createdTime=Tue Feb 14 19:46:12 CST 2017, time=2017-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=172830, encodeId=16931e28306c, content=其实也是有能重复出来的研究的, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=071c2012037, createdName=wmu姿, createdTime=Fri Jan 27 08:47:47 CST 2017, time=2017-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068486, encodeId=fe342068486cd, content=<a href='/topic/show?id=59371088215' target=_blank style='color:#2F92EE;'>#Life#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10882, encryptionId=59371088215, topicName=Life)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Thu May 11 23:45:00 CST 2017, time=2017-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171806, encodeId=c7b41e1806ec, content=这几篇顶级文章没有中国人的,如果选择中国人的文章,结果会如何?, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jan 21 11:56:02 CST 2017, time=2017-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171805, encodeId=c10f1e1805ac, content=很多实验是第三方公司做的,结果完全根据需要而产生!, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jan 21 11:55:18 CST 2017, time=2017-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171629, encodeId=94061e162907, content=飘过,围观, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuHfSLw3PzIKiaSnTBUuAtRkrrxWpibukl35iciaGtBq4LYQv4ian1tPC3IdmzWI2dZ3cDC8wUg5CnBxlJ/0, createdBy=33a51675735, createdName=jiangxianchen, createdTime=Fri Jan 20 16:47:17 CST 2017, time=2017-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171628, encodeId=b5801e162858, content=天下乌鸦一样啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fb8a1655102, createdName=米2301, createdTime=Fri Jan 20 16:40:16 CST 2017, time=2017-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171613, encodeId=a3271e161367, content=觉得发的优秀的文章,本身就应该要有重复性,才更有说服力,然而...?, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0761981653, createdName=Ailyre, createdTime=Fri Jan 20 15:23:45 CST 2017, time=2017-01-20, status=1, ipAttribution=)]
    2017-05-11 clmlylxy
  6. [GetPortalCommentsPageByObjectIdResponse(id=1751552, encodeId=8f091e5155222, content=<a href='/topic/show?id=713d95e399f' target=_blank style='color:#2F92EE;'>#重复性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95739, encryptionId=713d95e399f, topicName=重复性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ced636322728, createdName=珙桐, createdTime=Mon Jul 10 00:45:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1972985, encodeId=e6a119e2985d6, content=<a href='/topic/show?id=72d566e3a6' target=_blank style='color:#2F92EE;'>#eLife#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6673, encryptionId=72d566e3a6, topicName=eLife)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Sun May 14 15:45:00 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=176157, encodeId=2f431e61574f, content=只能呵呵了, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=071c2012037, createdName=wmu姿, createdTime=Tue Feb 14 19:46:12 CST 2017, time=2017-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=172830, encodeId=16931e28306c, content=其实也是有能重复出来的研究的, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=071c2012037, createdName=wmu姿, createdTime=Fri Jan 27 08:47:47 CST 2017, time=2017-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068486, encodeId=fe342068486cd, content=<a href='/topic/show?id=59371088215' target=_blank style='color:#2F92EE;'>#Life#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10882, encryptionId=59371088215, topicName=Life)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Thu May 11 23:45:00 CST 2017, time=2017-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171806, encodeId=c7b41e1806ec, content=这几篇顶级文章没有中国人的,如果选择中国人的文章,结果会如何?, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jan 21 11:56:02 CST 2017, time=2017-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171805, encodeId=c10f1e1805ac, content=很多实验是第三方公司做的,结果完全根据需要而产生!, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jan 21 11:55:18 CST 2017, time=2017-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171629, encodeId=94061e162907, content=飘过,围观, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuHfSLw3PzIKiaSnTBUuAtRkrrxWpibukl35iciaGtBq4LYQv4ian1tPC3IdmzWI2dZ3cDC8wUg5CnBxlJ/0, createdBy=33a51675735, createdName=jiangxianchen, createdTime=Fri Jan 20 16:47:17 CST 2017, time=2017-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171628, encodeId=b5801e162858, content=天下乌鸦一样啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fb8a1655102, createdName=米2301, createdTime=Fri Jan 20 16:40:16 CST 2017, time=2017-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171613, encodeId=a3271e161367, content=觉得发的优秀的文章,本身就应该要有重复性,才更有说服力,然而...?, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0761981653, createdName=Ailyre, createdTime=Fri Jan 20 15:23:45 CST 2017, time=2017-01-20, status=1, ipAttribution=)]
    2017-01-21 lovetcm

    这几篇顶级文章没有中国人的,如果选择中国人的文章,结果会如何?

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1751552, encodeId=8f091e5155222, content=<a href='/topic/show?id=713d95e399f' target=_blank style='color:#2F92EE;'>#重复性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95739, encryptionId=713d95e399f, topicName=重复性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ced636322728, createdName=珙桐, createdTime=Mon Jul 10 00:45:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1972985, encodeId=e6a119e2985d6, content=<a href='/topic/show?id=72d566e3a6' target=_blank style='color:#2F92EE;'>#eLife#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6673, encryptionId=72d566e3a6, topicName=eLife)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Sun May 14 15:45:00 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=176157, encodeId=2f431e61574f, content=只能呵呵了, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=071c2012037, createdName=wmu姿, createdTime=Tue Feb 14 19:46:12 CST 2017, time=2017-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=172830, encodeId=16931e28306c, content=其实也是有能重复出来的研究的, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=071c2012037, createdName=wmu姿, createdTime=Fri Jan 27 08:47:47 CST 2017, time=2017-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068486, encodeId=fe342068486cd, content=<a href='/topic/show?id=59371088215' target=_blank style='color:#2F92EE;'>#Life#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10882, encryptionId=59371088215, topicName=Life)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Thu May 11 23:45:00 CST 2017, time=2017-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171806, encodeId=c7b41e1806ec, content=这几篇顶级文章没有中国人的,如果选择中国人的文章,结果会如何?, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jan 21 11:56:02 CST 2017, time=2017-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171805, encodeId=c10f1e1805ac, content=很多实验是第三方公司做的,结果完全根据需要而产生!, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jan 21 11:55:18 CST 2017, time=2017-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171629, encodeId=94061e162907, content=飘过,围观, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuHfSLw3PzIKiaSnTBUuAtRkrrxWpibukl35iciaGtBq4LYQv4ian1tPC3IdmzWI2dZ3cDC8wUg5CnBxlJ/0, createdBy=33a51675735, createdName=jiangxianchen, createdTime=Fri Jan 20 16:47:17 CST 2017, time=2017-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171628, encodeId=b5801e162858, content=天下乌鸦一样啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fb8a1655102, createdName=米2301, createdTime=Fri Jan 20 16:40:16 CST 2017, time=2017-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171613, encodeId=a3271e161367, content=觉得发的优秀的文章,本身就应该要有重复性,才更有说服力,然而...?, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0761981653, createdName=Ailyre, createdTime=Fri Jan 20 15:23:45 CST 2017, time=2017-01-20, status=1, ipAttribution=)]
    2017-01-21 lovetcm

    很多实验是第三方公司做的,结果完全根据需要而产生!

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1751552, encodeId=8f091e5155222, content=<a href='/topic/show?id=713d95e399f' target=_blank style='color:#2F92EE;'>#重复性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95739, encryptionId=713d95e399f, topicName=重复性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ced636322728, createdName=珙桐, createdTime=Mon Jul 10 00:45:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1972985, encodeId=e6a119e2985d6, content=<a href='/topic/show?id=72d566e3a6' target=_blank style='color:#2F92EE;'>#eLife#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6673, encryptionId=72d566e3a6, topicName=eLife)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Sun May 14 15:45:00 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=176157, encodeId=2f431e61574f, content=只能呵呵了, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=071c2012037, createdName=wmu姿, createdTime=Tue Feb 14 19:46:12 CST 2017, time=2017-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=172830, encodeId=16931e28306c, content=其实也是有能重复出来的研究的, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=071c2012037, createdName=wmu姿, createdTime=Fri Jan 27 08:47:47 CST 2017, time=2017-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068486, encodeId=fe342068486cd, content=<a href='/topic/show?id=59371088215' target=_blank style='color:#2F92EE;'>#Life#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10882, encryptionId=59371088215, topicName=Life)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Thu May 11 23:45:00 CST 2017, time=2017-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171806, encodeId=c7b41e1806ec, content=这几篇顶级文章没有中国人的,如果选择中国人的文章,结果会如何?, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jan 21 11:56:02 CST 2017, time=2017-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171805, encodeId=c10f1e1805ac, content=很多实验是第三方公司做的,结果完全根据需要而产生!, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jan 21 11:55:18 CST 2017, time=2017-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171629, encodeId=94061e162907, content=飘过,围观, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuHfSLw3PzIKiaSnTBUuAtRkrrxWpibukl35iciaGtBq4LYQv4ian1tPC3IdmzWI2dZ3cDC8wUg5CnBxlJ/0, createdBy=33a51675735, createdName=jiangxianchen, createdTime=Fri Jan 20 16:47:17 CST 2017, time=2017-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171628, encodeId=b5801e162858, content=天下乌鸦一样啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fb8a1655102, createdName=米2301, createdTime=Fri Jan 20 16:40:16 CST 2017, time=2017-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171613, encodeId=a3271e161367, content=觉得发的优秀的文章,本身就应该要有重复性,才更有说服力,然而...?, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0761981653, createdName=Ailyre, createdTime=Fri Jan 20 15:23:45 CST 2017, time=2017-01-20, status=1, ipAttribution=)]
    2017-01-20 jiangxianchen

    飘过,围观

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1751552, encodeId=8f091e5155222, content=<a href='/topic/show?id=713d95e399f' target=_blank style='color:#2F92EE;'>#重复性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95739, encryptionId=713d95e399f, topicName=重复性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ced636322728, createdName=珙桐, createdTime=Mon Jul 10 00:45:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1972985, encodeId=e6a119e2985d6, content=<a href='/topic/show?id=72d566e3a6' target=_blank style='color:#2F92EE;'>#eLife#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6673, encryptionId=72d566e3a6, topicName=eLife)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Sun May 14 15:45:00 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=176157, encodeId=2f431e61574f, content=只能呵呵了, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=071c2012037, createdName=wmu姿, createdTime=Tue Feb 14 19:46:12 CST 2017, time=2017-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=172830, encodeId=16931e28306c, content=其实也是有能重复出来的研究的, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=071c2012037, createdName=wmu姿, createdTime=Fri Jan 27 08:47:47 CST 2017, time=2017-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068486, encodeId=fe342068486cd, content=<a href='/topic/show?id=59371088215' target=_blank style='color:#2F92EE;'>#Life#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10882, encryptionId=59371088215, topicName=Life)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Thu May 11 23:45:00 CST 2017, time=2017-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171806, encodeId=c7b41e1806ec, content=这几篇顶级文章没有中国人的,如果选择中国人的文章,结果会如何?, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jan 21 11:56:02 CST 2017, time=2017-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171805, encodeId=c10f1e1805ac, content=很多实验是第三方公司做的,结果完全根据需要而产生!, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jan 21 11:55:18 CST 2017, time=2017-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171629, encodeId=94061e162907, content=飘过,围观, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuHfSLw3PzIKiaSnTBUuAtRkrrxWpibukl35iciaGtBq4LYQv4ian1tPC3IdmzWI2dZ3cDC8wUg5CnBxlJ/0, createdBy=33a51675735, createdName=jiangxianchen, createdTime=Fri Jan 20 16:47:17 CST 2017, time=2017-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171628, encodeId=b5801e162858, content=天下乌鸦一样啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fb8a1655102, createdName=米2301, createdTime=Fri Jan 20 16:40:16 CST 2017, time=2017-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171613, encodeId=a3271e161367, content=觉得发的优秀的文章,本身就应该要有重复性,才更有说服力,然而...?, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0761981653, createdName=Ailyre, createdTime=Fri Jan 20 15:23:45 CST 2017, time=2017-01-20, status=1, ipAttribution=)]
    2017-01-20 米2301

    天下乌鸦一样啊

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1751552, encodeId=8f091e5155222, content=<a href='/topic/show?id=713d95e399f' target=_blank style='color:#2F92EE;'>#重复性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95739, encryptionId=713d95e399f, topicName=重复性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ced636322728, createdName=珙桐, createdTime=Mon Jul 10 00:45:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1972985, encodeId=e6a119e2985d6, content=<a href='/topic/show?id=72d566e3a6' target=_blank style='color:#2F92EE;'>#eLife#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6673, encryptionId=72d566e3a6, topicName=eLife)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Sun May 14 15:45:00 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=176157, encodeId=2f431e61574f, content=只能呵呵了, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=071c2012037, createdName=wmu姿, createdTime=Tue Feb 14 19:46:12 CST 2017, time=2017-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=172830, encodeId=16931e28306c, content=其实也是有能重复出来的研究的, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=071c2012037, createdName=wmu姿, createdTime=Fri Jan 27 08:47:47 CST 2017, time=2017-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068486, encodeId=fe342068486cd, content=<a href='/topic/show?id=59371088215' target=_blank style='color:#2F92EE;'>#Life#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10882, encryptionId=59371088215, topicName=Life)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Thu May 11 23:45:00 CST 2017, time=2017-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171806, encodeId=c7b41e1806ec, content=这几篇顶级文章没有中国人的,如果选择中国人的文章,结果会如何?, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jan 21 11:56:02 CST 2017, time=2017-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171805, encodeId=c10f1e1805ac, content=很多实验是第三方公司做的,结果完全根据需要而产生!, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jan 21 11:55:18 CST 2017, time=2017-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171629, encodeId=94061e162907, content=飘过,围观, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuHfSLw3PzIKiaSnTBUuAtRkrrxWpibukl35iciaGtBq4LYQv4ian1tPC3IdmzWI2dZ3cDC8wUg5CnBxlJ/0, createdBy=33a51675735, createdName=jiangxianchen, createdTime=Fri Jan 20 16:47:17 CST 2017, time=2017-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171628, encodeId=b5801e162858, content=天下乌鸦一样啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fb8a1655102, createdName=米2301, createdTime=Fri Jan 20 16:40:16 CST 2017, time=2017-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171613, encodeId=a3271e161367, content=觉得发的优秀的文章,本身就应该要有重复性,才更有说服力,然而...?, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0761981653, createdName=Ailyre, createdTime=Fri Jan 20 15:23:45 CST 2017, time=2017-01-20, status=1, ipAttribution=)]
    2017-01-20 Ailyre

    觉得发的优秀的文章,本身就应该要有重复性,才更有说服力,然而...?

    0

Baidu
map
Baidu
map
Baidu
map