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JAMA:舒张压较低与脑萎缩进展较快相关

2013-07-19 高晓方 译 JAMA

荷兰一项研究表明,在伴有动脉疾病表现的患者中,基线舒张压较低与脑皮质下萎缩进展较快具有相关性,并且与随访期间的血压进程无关。论文6月10日在线发表于《美国医学会 神经病学》杂志(JAMA Neurol)。 此项前瞻性研究共纳入663例伴有冠脉疾病、脑血管病、周围动脉病或腹主动脉瘤的患者(平均年龄57岁)。利用基线和随访时自动分段对脑实质分数、皮层灰质分数和脑室分数进行定量,以判断整体、

荷兰一项研究表明,在伴有动脉疾病表现的患者中,基线舒张压较低与脑皮质下萎缩进展较快具有相关性,并且与随访期间的血压进程无关。论文6月10日在线发表于《美国医学会 神经病学》杂志(JAMA Neurol)。

此项前瞻性研究共纳入663例伴有冠脉疾病、脑血管病、周围动脉病或腹主动脉瘤的患者(平均年龄57岁)。利用基线和随访时自动分段对脑实质分数、皮层灰质分数和脑室分数进行定量,以判断整体、皮质和皮质下脑萎缩进展。平均随访时间为3.9年。

结果显示,多变量校正回归分析表明,基线舒张压或平均动脉压较低的患者皮质下萎缩进展更显著。高、低舒张压患者的脑室分数变化平均差异为0.07%,高、低平均动脉压患者则为0.05%。此外,在基线血压(舒张压、平均动脉压或收缩压)较高的患者中,血压降低者随时间推移的皮质下萎缩进展轻于血压升高者。

原始出处:

Hadassa M. Jochemsen, MD; Majon Muller, MD, PhD; Frank L. Visseren, MD, PhD; Philip Scheltens, MD, PhD; Koen L. Vincken, PhD; Willem P. Mali, MD, PhD; Yolanda van der Graaf, MD, PhD; Mirjam I. Geerlings, PhD; for the SMART Study Group.Blood Pressure and Progression of Brain AtrophyThe SMART-MR Study,June 10, 2013.JAMA Neurol. 2013;():1-7. doi:10.1001/jamaneurol.

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