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Thorax:癌症治疗的地理差异与肺癌患者的生存率相关

2018-03-15 xiangting MedSci原创

不同治疗方式的使用程度在英国各地区之间有所不同。这些差异并不能归因于接受检查的患者和肿瘤特征,而是更多的反映了当地多学科团队在临床治疗方面的差异。

英国肺癌患者的预后不如同等国家。患者或疾病特征、就医行为、诊断途径和肿瘤服务可能导致了这种结果。这项研究旨在量化英国肺癌治疗的地理差异与患者生存率的关联。

研究人员检索了详细的癌症登记数据,以分析2010年至2014年确诊的176,225例肺癌患者生存率的变化。使用Kaplan-Meier分析和Cox比例风险回归来分析诊断后两年的生存率。

研究期间生存率有所改善。不同地理区域积极疗法的使用有所差异,手术切除的五分位范围为9%-17%,根治性放疗为4%-13%,化疗为22%-35%。2年时,如果所有治疗比例均与最高五分位数相同,手术切除的每年可避免死亡人数为188人,根治性放疗为373人。在第6个月的时间点,如果所有患者的化疗使用率达到最高五分位数,则每年可能推迟318例死亡。在根据年龄、性别、社会经济状况,表现状态和合并症调整后,结果仍然有效。

不同治疗方式的使用程度在英国各地区之间有所不同。这些差异并不能归因于接受检查的患者和肿瘤特征,而是更多的反映了当地多学科团队在临床治疗方面的差异。数据显示随时间推移,生存率有所改善,但如果在所有地区使用积极疗法并达到目前最高区域的比例,则会有进一步更多的生存获益。

原始出处:

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    2018-03-15 天地飞扬

    了解一下.谢谢分享!

    0

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    2018-03-15 戒馋,懒,贪

    谢谢分享学习了

    0

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