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CLIN CANCER RES：p95HER2可以预测Trastuzumab辅助治疗临床获益

2018-07-03 MedSci MedSci原创

p95HER2Trastuzumab临床获益
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p95HER2是是HER2受体的缩短形态，缺少Trastuzumab结合位点但仍具有酶活性，之前已有报道其可以作为接受Trastuzumab治疗的HER2阳性转移性乳腺癌患者不良预后标志。p95表达对早期HER2阳性乳腺癌患者接受Trastuzumab治疗效果的影响尚不清楚。CLIN CANCER RES近期发表了一篇文章，研究p95是否可以作为HER2阳性乳腺癌患者接受Trastuzumab治疗

p95HER2是是HER2受体的缩短形态，缺少Trastuzumab结合位点但仍具有酶活性，之前已有报道其可以作为接受Trastuzumab治疗的HER2阳性转移性乳腺癌患者不良预后标志。p95表达对早期HER2阳性乳腺癌患者接受Trastuzumab治疗效果的影响尚不清楚。CLIN CANCER RES近期发表了一篇文章，研究p95是否可以作为HER2阳性乳腺癌患者接受Trastuzumab治疗获益的预测标志。

在FinHer临床试验中，232例HER2阳性早期乳腺癌患者随机分为两组，分别接受化疗联合9周Trastuzumab治疗或单纯化疗。检测肿瘤标本中p95蛋白以及HER2蛋白表达。远处无病生存（DDFS）是主要的研究结果。研究结果表明，在仅接受化疗的队列中，log10（p95）增加与DDFS缩短有关。在接受化疗联合Trastuzumab治疗队列中，log10(p95)增加与DDFS缩短无关。对两个队列综合分析结果表明，在多因素模型中乳腺癌p95高表达与Trastuzumab治疗获益显着相关。

文章最后认为，高p95HER2/HER2比值有助于区别接受Trastuzumab治疗效果不佳的转移性乳腺癌患者。未来需要对p95HER2/HER2比值作为HER2靶向治疗的预后指标进行进一步研究。

原始出处：
Jeff Sperinde,Weidong Huang,et al.p95HER2 Methionine 611 Carboxy-Terminal Fragment Is Predictive of Trastuzumab Adjuvant Treatment Benefit in the FinHer Trial.CLIN CANCER RES.July 2018 doi:10.1158/1078-0432.CCR-17-3250

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    2019-02-11 snf701207

    #mAb#

    0

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    2019-05-30 ms24272190615788285182

    #AST#

    0

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    2018-11-23 朱睿睿

    #临床获益#

    0

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    2018-10-09 bsmagic9140

    #TRA#

    0

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