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为什么头发越来越少?因为头皮越来越多

2016-04-19 魏昕宇 编译 科学公园

随着年龄的增长,人的头发逐渐变得稀疏,这是众所周知的事实,但是这种现象究竟为什么会发生?一项新的研究揭开了谜团:衰老导致毛囊干细胞逐渐变为表皮角质细胞,从而使得毛囊失去了生长头发的能力。(图片来源:http://www.midwest-antiaging.com/facial-treatments/prp-hair-restoration/)来自日本等国的研究人员通过对小鼠进行实验表明,随着年龄的

随着年龄的增长,人的头发逐渐变得稀疏,这是众所周知的事实,但是这种现象究竟为什么会发生?一项新的研究揭开了谜团:衰老导致毛囊干细胞逐渐变为表皮角质细胞,从而使得毛囊失去了生长头发的能力。

(图片来源:http://www.midwest-antiaging.com/facial-treatments/prp-hair-restoration/)

来自日本等国的研究人员通过对小鼠进行实验表明,随着年龄的增加,毛囊干细胞DNA的不断受损会导致细胞中一种名为Collagen 17A1的胶原蛋白发生酶解而被破坏,而这种蛋白的被破坏又导致毛囊干细胞转化为表皮角质细胞并脱落。这会导致毛囊逐渐缩小,最终彻底变成表皮组织,失去了再生毛发的能力。而如果让Collagen 17A1过度表达,毛囊干细胞向表皮角质细胞的转化就会受到抑制。随后研究人员又对不同年龄段的妇女的毛囊情况进行了比较,结果发现随着年龄的增长,毛囊确实变得越来越小,而Collagen 17A1的含量也在降低,表明人的衰老导致的头发稀疏同样是由于这种机理导致。这项研究发表在最新一期的《科学》杂志上。

这一期的《科学》杂志还报道了另一项有关毛发生长的研究。毛囊干细胞会交替进入生长和休眠阶段,在休眠阶段不会有新的毛发生长出来。来自美国的研究人员发现,Foxc1这种转录因子能够调节毛囊干细胞的这种循环,而扰乱它的表达则会干扰毛囊干细胞在两种状态之间的转变。这两项研究有助于我们更好地了解头发的生长。

原始出处:

Hiroyuki Matsumura1,*, Yasuaki Mohri1,*, Nguyen Thanh Binh1,2,*, Hironobu Morinaga1, Makoto Fukuda1, Mayumi Ito3, Sotaro Kurata4, Jan Hoeijmakers5, Emi K. Nishimura1,†.Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis.Science 05 Feb 2016:Vol. 351, Issue 6273, DOI: 10.1126/science.aad4395

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    2016-04-23 吴玲

    理论知识又多学了一个

    0

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    2016-04-21 qindq
  3. [GetPortalCommentsPageByObjectIdResponse(id=81713, encodeId=fdc681e13b5, content=理论知识又多学了一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160602/IMG574F7F78D7F702220.jpg, createdBy=5d0b1713419, createdName=吴玲, createdTime=Sat Apr 23 10:16:00 CST 2016, time=2016-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468583, encodeId=b1f51468583b8, content=<a href='/topic/show?id=7f7f443337a' target=_blank style='color:#2F92EE;'>#头发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44333, encryptionId=7f7f443337a, topicName=头发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f09e6924959, createdName=qindq, createdTime=Thu Apr 21 04:16:00 CST 2016, time=2016-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79846, encodeId=ddfce984690, content=感觉人能健康活着真是不容易啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4371683642, createdName=文医生, createdTime=Wed Apr 20 21:35:00 CST 2016, time=2016-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79730, encodeId=9227e973017, content=脱发控制不住, beContent=null, objectType=article, channel=null, level=null, likeNumber=193, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzYWia0nMBiceOVIdKq3ibFKubbK7gTtfD7KAF6ogXiceRzVH2drFiaow6ibIukSoyFPpHDd9xdGSOj8hcZ/0, createdBy=41f01710035, createdName=醉清风, createdTime=Wed Apr 20 01:18:00 CST 2016, time=2016-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79719, encodeId=72bde97196c, content=学习啦!, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9da51712760, createdName=qq1e1c69fe, createdTime=Tue Apr 19 21:56:00 CST 2016, time=2016-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79640, encodeId=44c8e964085, content=长知识了,学习~, beContent=null, objectType=article, channel=null, level=null, likeNumber=254, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn/upload/content/day_160326/201603262025001865.jpg, createdBy=c7881618185, createdName=qian0416, createdTime=Tue Apr 19 18:50:00 CST 2016, time=2016-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79625, encodeId=03fde96257d, content=长知识啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Tue Apr 19 18:05:00 CST 2016, time=2016-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79626, encodeId=5217e962666, content=原来如此, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Tue Apr 19 18:05:00 CST 2016, time=2016-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79556, encodeId=5a8be955621, content=涨知识了,不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cc71713672, createdName=hewenda, createdTime=Tue Apr 19 14:21:00 CST 2016, time=2016-04-19, status=1, ipAttribution=)]
    2016-04-20 文医生

    感觉人能健康活着真是不容易啊

    0

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    2016-04-20 醉清风

    脱发控制不住

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=81713, encodeId=fdc681e13b5, content=理论知识又多学了一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160602/IMG574F7F78D7F702220.jpg, createdBy=5d0b1713419, createdName=吴玲, createdTime=Sat Apr 23 10:16:00 CST 2016, time=2016-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468583, encodeId=b1f51468583b8, content=<a href='/topic/show?id=7f7f443337a' target=_blank style='color:#2F92EE;'>#头发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44333, encryptionId=7f7f443337a, topicName=头发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f09e6924959, createdName=qindq, createdTime=Thu Apr 21 04:16:00 CST 2016, time=2016-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79846, encodeId=ddfce984690, content=感觉人能健康活着真是不容易啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4371683642, createdName=文医生, createdTime=Wed Apr 20 21:35:00 CST 2016, time=2016-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79730, encodeId=9227e973017, content=脱发控制不住, beContent=null, objectType=article, channel=null, level=null, likeNumber=193, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzYWia0nMBiceOVIdKq3ibFKubbK7gTtfD7KAF6ogXiceRzVH2drFiaow6ibIukSoyFPpHDd9xdGSOj8hcZ/0, createdBy=41f01710035, createdName=醉清风, createdTime=Wed Apr 20 01:18:00 CST 2016, time=2016-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79719, encodeId=72bde97196c, content=学习啦!, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9da51712760, createdName=qq1e1c69fe, createdTime=Tue Apr 19 21:56:00 CST 2016, time=2016-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79640, encodeId=44c8e964085, content=长知识了,学习~, beContent=null, objectType=article, channel=null, level=null, likeNumber=254, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn/upload/content/day_160326/201603262025001865.jpg, createdBy=c7881618185, createdName=qian0416, createdTime=Tue Apr 19 18:50:00 CST 2016, time=2016-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79625, encodeId=03fde96257d, content=长知识啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Tue Apr 19 18:05:00 CST 2016, time=2016-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79626, encodeId=5217e962666, content=原来如此, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Tue Apr 19 18:05:00 CST 2016, time=2016-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79556, encodeId=5a8be955621, content=涨知识了,不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cc71713672, createdName=hewenda, createdTime=Tue Apr 19 14:21:00 CST 2016, time=2016-04-19, status=1, ipAttribution=)]
    2016-04-19 qq1e1c69fe

    学习啦!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=81713, encodeId=fdc681e13b5, content=理论知识又多学了一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160602/IMG574F7F78D7F702220.jpg, createdBy=5d0b1713419, createdName=吴玲, createdTime=Sat Apr 23 10:16:00 CST 2016, time=2016-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468583, encodeId=b1f51468583b8, content=<a href='/topic/show?id=7f7f443337a' target=_blank style='color:#2F92EE;'>#头发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44333, encryptionId=7f7f443337a, topicName=头发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f09e6924959, createdName=qindq, createdTime=Thu Apr 21 04:16:00 CST 2016, time=2016-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79846, encodeId=ddfce984690, content=感觉人能健康活着真是不容易啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4371683642, createdName=文医生, createdTime=Wed Apr 20 21:35:00 CST 2016, time=2016-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79730, encodeId=9227e973017, content=脱发控制不住, beContent=null, objectType=article, channel=null, level=null, likeNumber=193, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzYWia0nMBiceOVIdKq3ibFKubbK7gTtfD7KAF6ogXiceRzVH2drFiaow6ibIukSoyFPpHDd9xdGSOj8hcZ/0, createdBy=41f01710035, createdName=醉清风, createdTime=Wed Apr 20 01:18:00 CST 2016, time=2016-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79719, encodeId=72bde97196c, content=学习啦!, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9da51712760, createdName=qq1e1c69fe, createdTime=Tue Apr 19 21:56:00 CST 2016, time=2016-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79640, encodeId=44c8e964085, content=长知识了,学习~, beContent=null, objectType=article, channel=null, level=null, likeNumber=254, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn/upload/content/day_160326/201603262025001865.jpg, createdBy=c7881618185, createdName=qian0416, createdTime=Tue Apr 19 18:50:00 CST 2016, time=2016-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79625, encodeId=03fde96257d, content=长知识啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Tue Apr 19 18:05:00 CST 2016, time=2016-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79626, encodeId=5217e962666, content=原来如此, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Tue Apr 19 18:05:00 CST 2016, time=2016-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79556, encodeId=5a8be955621, content=涨知识了,不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cc71713672, createdName=hewenda, createdTime=Tue Apr 19 14:21:00 CST 2016, time=2016-04-19, status=1, ipAttribution=)]
    2016-04-19 qian0416

    长知识了,学习~

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=81713, encodeId=fdc681e13b5, content=理论知识又多学了一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160602/IMG574F7F78D7F702220.jpg, createdBy=5d0b1713419, createdName=吴玲, createdTime=Sat Apr 23 10:16:00 CST 2016, time=2016-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468583, encodeId=b1f51468583b8, content=<a href='/topic/show?id=7f7f443337a' target=_blank style='color:#2F92EE;'>#头发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44333, encryptionId=7f7f443337a, topicName=头发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f09e6924959, createdName=qindq, createdTime=Thu Apr 21 04:16:00 CST 2016, time=2016-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79846, encodeId=ddfce984690, content=感觉人能健康活着真是不容易啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4371683642, createdName=文医生, createdTime=Wed Apr 20 21:35:00 CST 2016, time=2016-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79730, encodeId=9227e973017, content=脱发控制不住, beContent=null, objectType=article, channel=null, level=null, likeNumber=193, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzYWia0nMBiceOVIdKq3ibFKubbK7gTtfD7KAF6ogXiceRzVH2drFiaow6ibIukSoyFPpHDd9xdGSOj8hcZ/0, createdBy=41f01710035, createdName=醉清风, createdTime=Wed Apr 20 01:18:00 CST 2016, time=2016-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79719, encodeId=72bde97196c, content=学习啦!, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9da51712760, createdName=qq1e1c69fe, createdTime=Tue Apr 19 21:56:00 CST 2016, time=2016-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79640, encodeId=44c8e964085, content=长知识了,学习~, beContent=null, objectType=article, channel=null, level=null, likeNumber=254, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn/upload/content/day_160326/201603262025001865.jpg, createdBy=c7881618185, createdName=qian0416, createdTime=Tue Apr 19 18:50:00 CST 2016, time=2016-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79625, encodeId=03fde96257d, content=长知识啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Tue Apr 19 18:05:00 CST 2016, time=2016-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79626, encodeId=5217e962666, content=原来如此, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Tue Apr 19 18:05:00 CST 2016, time=2016-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79556, encodeId=5a8be955621, content=涨知识了,不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cc71713672, createdName=hewenda, createdTime=Tue Apr 19 14:21:00 CST 2016, time=2016-04-19, status=1, ipAttribution=)]
    2016-04-19 李继凯

    长知识啊

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=81713, encodeId=fdc681e13b5, content=理论知识又多学了一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160602/IMG574F7F78D7F702220.jpg, createdBy=5d0b1713419, createdName=吴玲, createdTime=Sat Apr 23 10:16:00 CST 2016, time=2016-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468583, encodeId=b1f51468583b8, content=<a href='/topic/show?id=7f7f443337a' target=_blank style='color:#2F92EE;'>#头发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44333, encryptionId=7f7f443337a, topicName=头发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f09e6924959, createdName=qindq, createdTime=Thu Apr 21 04:16:00 CST 2016, time=2016-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79846, encodeId=ddfce984690, content=感觉人能健康活着真是不容易啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4371683642, createdName=文医生, createdTime=Wed Apr 20 21:35:00 CST 2016, time=2016-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79730, encodeId=9227e973017, content=脱发控制不住, beContent=null, objectType=article, channel=null, level=null, likeNumber=193, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzYWia0nMBiceOVIdKq3ibFKubbK7gTtfD7KAF6ogXiceRzVH2drFiaow6ibIukSoyFPpHDd9xdGSOj8hcZ/0, createdBy=41f01710035, createdName=醉清风, createdTime=Wed Apr 20 01:18:00 CST 2016, time=2016-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79719, encodeId=72bde97196c, content=学习啦!, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9da51712760, createdName=qq1e1c69fe, createdTime=Tue Apr 19 21:56:00 CST 2016, time=2016-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79640, encodeId=44c8e964085, content=长知识了,学习~, beContent=null, objectType=article, channel=null, level=null, likeNumber=254, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn/upload/content/day_160326/201603262025001865.jpg, createdBy=c7881618185, createdName=qian0416, createdTime=Tue Apr 19 18:50:00 CST 2016, time=2016-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79625, encodeId=03fde96257d, content=长知识啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Tue Apr 19 18:05:00 CST 2016, time=2016-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79626, encodeId=5217e962666, content=原来如此, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Tue Apr 19 18:05:00 CST 2016, time=2016-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79556, encodeId=5a8be955621, content=涨知识了,不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cc71713672, createdName=hewenda, createdTime=Tue Apr 19 14:21:00 CST 2016, time=2016-04-19, status=1, ipAttribution=)]
    2016-04-19 李继凯

    原来如此

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=81713, encodeId=fdc681e13b5, content=理论知识又多学了一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160602/IMG574F7F78D7F702220.jpg, createdBy=5d0b1713419, createdName=吴玲, createdTime=Sat Apr 23 10:16:00 CST 2016, time=2016-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468583, encodeId=b1f51468583b8, content=<a href='/topic/show?id=7f7f443337a' target=_blank style='color:#2F92EE;'>#头发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44333, encryptionId=7f7f443337a, topicName=头发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f09e6924959, createdName=qindq, createdTime=Thu Apr 21 04:16:00 CST 2016, time=2016-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79846, encodeId=ddfce984690, content=感觉人能健康活着真是不容易啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4371683642, createdName=文医生, createdTime=Wed Apr 20 21:35:00 CST 2016, time=2016-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79730, encodeId=9227e973017, content=脱发控制不住, beContent=null, objectType=article, channel=null, level=null, likeNumber=193, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzYWia0nMBiceOVIdKq3ibFKubbK7gTtfD7KAF6ogXiceRzVH2drFiaow6ibIukSoyFPpHDd9xdGSOj8hcZ/0, createdBy=41f01710035, createdName=醉清风, createdTime=Wed Apr 20 01:18:00 CST 2016, time=2016-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79719, encodeId=72bde97196c, content=学习啦!, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9da51712760, createdName=qq1e1c69fe, createdTime=Tue Apr 19 21:56:00 CST 2016, time=2016-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79640, encodeId=44c8e964085, content=长知识了,学习~, beContent=null, objectType=article, channel=null, level=null, likeNumber=254, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn/upload/content/day_160326/201603262025001865.jpg, createdBy=c7881618185, createdName=qian0416, createdTime=Tue Apr 19 18:50:00 CST 2016, time=2016-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79625, encodeId=03fde96257d, content=长知识啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Tue Apr 19 18:05:00 CST 2016, time=2016-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79626, encodeId=5217e962666, content=原来如此, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Tue Apr 19 18:05:00 CST 2016, time=2016-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79556, encodeId=5a8be955621, content=涨知识了,不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cc71713672, createdName=hewenda, createdTime=Tue Apr 19 14:21:00 CST 2016, time=2016-04-19, status=1, ipAttribution=)]
    2016-04-19 hewenda

    涨知识了,不错

    0

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