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Int J Environ Res Public Health:男性警惕慢性牙周炎患者!可增加颈动脉粥样硬化的发病风险

2020-03-17 MedSci原创 MedSci原创

颈动脉狭窄是通常由动脉粥样硬化引起的颈动脉任何部分的变窄或收缩。但是,尚无研究评估颈动脉粥样硬化(CA)与慢性牙周炎(CP)之间的关联。本研究旨在调查CP在台湾人群中增加CA发病风险中的作用。

颈动脉狭窄是通常由动脉粥样硬化引起的颈动脉任何部分的变窄或收缩。但是,尚无研究评估颈动脉粥样硬化(CA)与慢性牙周炎(CP)之间的关联。本研究旨在调查CP在台湾人群中增加CA发病风险中的作用。

 

研究人员利用来自国家健康保险研究数据库的数据进行了回顾性队列研究。从2001年至2012年,共选择了72,630名新诊断为CP的患者。随机抽取72,630例无CP的健康患者作为对照组,并根据年龄,性别和指数年份与普通人群进行匹配。采用Cox比例风险回归分析,包括性别,年龄和合并症,以评估CP人群和非CP人群之间CA的危险比(HR)。

 

结果,CP组和非CP组的平均年龄分别为44.02±14.63岁和44.15±14.41岁。CP组和非CP组的随访时间分别为8.65年和8.59年。结果表明,CP队列和非CP队列中分别有305例和284例新诊断为CA的患者。CP队列与非CP队列(校正后的HR)1.01,95%置信区间(CI,0.86-1.19)发展为CA的人群无明显差异。但是,多因素Cox回归分析表明,男性组患CA的风险明显较高(对数秩p = 0.046)。

 

总之,这项全国性的回顾性队列研究表明,男性CP患者比无CP的男性具有更高的CA风险。

 

原始出处:

 

Ching TongYu-Hsun WangYu-Chao Chang. Increased Risk of Carotid Atherosclerosis in Male Patients with Chronic Periodontitis: A Nationwide Population-Based Retrospective Cohort Study. Int J Environ Res Public Health. 2019 Aug; 16(15): 2635.  doi: 10.3390/ijerph16152635

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    2020-09-27 shizhenshan
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    2020-03-18 july_979
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