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Ther Clin Risk Manag:根面平整联合米诺环素局部应用可降低主要牙周致病菌的水平改善患者的症状

2016-02-21 MedSci MedSci原创

Ther Clin Risk Manag:根面平整联合米诺环素局部应用可降低主要牙周致病菌的水平改善患者的症状本研究旨在通过评估慢性牙周炎患者治疗后的各临床参数和四种主要的牙周致病菌的荷载量来评估分别单独应用或局部应用2%的米诺环素(MO)联合根面平整(SRP)的治疗效果。研究共纳入70名慢性牙周炎患者,随机分为三组:1)单独使用SRP;2)单独使用MO;3)SRP联合MO使用(SRP + MO)

目标

本研究旨在通过评估慢性牙周炎患者治疗后的各临床参数和四种主要的牙周致病菌的荷载量来评估分别单独应用或局部应用2%的米诺环素(MO)联合根面平整(SRP)的治疗效果。

方法

研究共纳入70名慢性牙周炎患者,随机分为三组:1)单独使用SRP;2)单独使用MO;3)SRP联合MO使用(SRP + MO)。治疗前和治疗一周后,研究人员评估了患者的牙周临床参数(牙周袋深度和龈沟出血指数)和四个主要牙周致病菌(伴放线放线杆菌Aa,具核梭杆菌Fn,牙龈卟啉单胞菌Pg和中间普氏菌Pi)的基因负载量。

结果

结果每名患者的细菌检出率为:Aa,31.25%;FN,100%;PG,95.31%;PI,98.44%。治疗一周后,三种治疗方法均可显著降低牙周袋深度和龈沟出血指数,但是并不能降低四种致病菌的检出率。与MO或SRP相比,SRP +MO可更明显降低患者的牙周袋深度。致病菌中只有Pg菌对SRP的反应较为明显。MO治疗后Pg和Fn的检出率明显降低。只有SRP +MO联合治疗时才可显著降低Pi的基因负荷。牙周袋深度的降低与Pi的基因负荷量降低有关,但是与其他细菌的基因负载量则无关系。

结论

总而言之,本研究表明SRP联合MO治疗时可降低PI的负载量,可改善患者的慢性牙周炎症状。

原始出处:


Shuli Deng, Ying Wang, Wei Sun, Hui Chen, and Gang Wu. Scaling and root planning, and locally delivered minocycline reduces the load of Prevotella intermedia in an interdependent pattern, correlating with symptomatic improvements of chronic periodontitis: a short-term randomized clinical trial. Ther Clin Risk Manag. 2015; 11: 1795–1803.Published online 2015 Dec 4. doi:  10.2147/TCRM.S93982

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    2016-08-27 AspirantSuo
  2. [GetPortalCommentsPageByObjectIdResponse(id=1633348, encodeId=cf9f1633348f5, content=<a href='/topic/show?id=377824e1c0' target=_blank style='color:#2F92EE;'>#ANA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2471, encryptionId=377824e1c0, topicName=ANA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=434d22047430, createdName=AspirantSuo, createdTime=Sat Aug 27 06:39:00 CST 2016, time=2016-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=124707, encodeId=5961124e0791, content=好文章,还会关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 13 11:02:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=124429, encodeId=9e4d12442935, content=赞一个!好文章拜读了,认真学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Sep 13 10:15:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2005142, encodeId=3e4b20051426d, content=<a href='/topic/show?id=2e1e6e542cb' target=_blank style='color:#2F92EE;'>#牙周致病菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67542, encryptionId=2e1e6e542cb, topicName=牙周致病菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60b4474, createdName=bbwuyu_003, createdTime=Sat Sep 03 19:39:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405688, encodeId=b547140568839, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Tue Feb 23 05:39:00 CST 2016, time=2016-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441202, encodeId=085f14412029e, content=<a href='/topic/show?id=0172e6110bf' target=_blank style='color:#2F92EE;'>#米诺环素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76110, encryptionId=0172e6110bf, topicName=米诺环素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=12284802660, createdName=ms5880526374914242, createdTime=Tue Feb 23 05:39:00 CST 2016, time=2016-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450449, encodeId=5ca21450449e9, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Tue Feb 23 05:39:00 CST 2016, time=2016-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626190, encodeId=d038162619081, content=<a href='/topic/show?id=c11d864884d' target=_blank style='color:#2F92EE;'>#致病菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86488, encryptionId=c11d864884d, topicName=致病菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Tue Feb 23 05:39:00 CST 2016, time=2016-02-23, status=1, ipAttribution=)]
    2016-09-13 1e10c84am36(暂无匿称)

    好文章,还会关注

    0

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    2016-09-13 ylzr123

    赞一个!好文章拜读了,认真学习了。

    0

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    2016-02-23 chg122
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