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J Cardiothorac Vasc An:单肺通气对七氟醚和地氟醚血药浓度的影响

2018-08-12 何幼芹 罂粟花

本实验旨在探究单肺通气(OLV)过程中七氟醚和地氟醚血药浓度的变化情况。

背景与目的:本实验旨在探究单肺通气(OLV)过程中七氟醚和地氟醚血药浓度的变化情况。

方法:本实验采用随机单盲研究。共纳入将实施腹部手术或开胸手术患者24名,年龄在35-70岁之间。将这些患者分为4组:双肺通气(TLV)七氟醚组、单肺通气七氟醚组、双肺通气地氟醚组和单肺通气地氟醚组。将七氟醚和地氟醚的挥发灌分别设置为1.5%和6%。在TLV组中,在通气进行40min后开始抽取血样进行血气分析和气相色谱分析,每间隔10min抽一次血样(T1-T9)。OLV组血样抽取同TLV组。记录SpO2、循环指标、吸入和呼气末挥发物的含量。在相同时间点记录每个患者挥发物的摄取分数。

结果:在OLV七氟醚组,平均动脉七氟醚浓度从T1时刻40.7± 4.4 mg/mL下降到T3时刻30.2 ±2.5 mg/mL(P = 0.014,下降 26%)。在TLV地氟醚组,平均动脉地氟醚的浓度从T1到T3的变化为224.6 ± 44.8 mg/mL到159.8 ± 32mg/mL(P=0.018, 下降29%)。然而,与地氟醚相比,七氟醚浓度在T3时的减少量无统计学意义(P = 0.31)。此外,挥发性药物的摄取分数在OLV开始时显着增加(P = 0.001)。

结论:OLV手术可降低七氟醚和地氟醚的血药浓度。

原始出处:

Biricik E, Karacaer F, Güne Y,et al. Effect of One-Lung Ventilation on Blood Sevofluraneand Desflurane Concentrations. J. Cardiothorac. Vasc. Anesth. 2018 Jun 01 DOI:10.1053/j.jvca.2018.05.032

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    2019-03-15 quxin068
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    2018-11-26 yyj062
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    2019-06-03 lsj628
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