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Clinica Chimica Acta:d -二聚体/纤维蛋白原比值对脑外伤后进行性出血的预测作用?

2020-06-22 MedSci原创 MedSci原创

进行性出血性损伤(PHI)严重影响创伤性脑损伤(TBI)的预后。目前研究表明,D-二聚体/纤维蛋白原比值(D/F比值)可能是静脉血栓栓塞的潜在预测因子。

进行性出血性损伤(PHI)严重影响创伤性脑损伤(TBI)的预后。目前研究表明,D-二聚体/纤维蛋白原比值(D/F比值)可能是静脉血栓栓塞的潜在预测因子。本研究试图描述和评价脑外伤后的D/F比值与PHI之间的关系。

这项回顾性研究纳入了192名TBI患者。研究人员通过测量血浆D-二聚体和纤维蛋白原,然后计算D / F比。 应用多元逻辑回归分析确定PHI的预测因子。构造了接收者工作特征(ROC)曲线以分析PHI的预测能力。。

格拉斯哥昏迷量表(GCS)得分(几率[OR]为0.565; 95%CI为0.464-0.689)和D / F比(OR为4.026; 95%CI为2.219-7.305)都是PHI的两个独立预测因子 。 D / F比的ROC曲线下面积(AUC)与GCS得分相似(AUC为0.816; 95%CI为0.754-0.868,而AUC为0.834; 95%CI为0.773-0.883; P = 0.699)。 此外,D / F比可将GCS评分的AUC显著提高至0.928(95%CI,0.881-0.960; P <0.001)。研究结果表明,D/F比值在研究队列中对PHI有较强的预测作用,因此在TBI患者的临床管理中应予以考虑。

原始出处:

De-Xiao Xu,Wu-Tao Du,D-dimer/fibrinogen ratio for the prediction of progressive hemorrhagic injury after traumatic brain injury

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    2020-06-23 windight
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