Baidu
map

感染

订阅

MedSci主页 / 所有栏目 / 感染

ANGEW CHEM INT EDIT：灵敏超级细菌检测法—灵敏高出普通10000倍

2015-07-08 佚名 生物谷

超级细胞检测法感染
关注

感染性疾病如丙型肝炎和世界上最致命的超级病菌—包括难辨梭状芽孢杆菌（C.difficile）和MRSA，可能很快在一种独特的诊断测试中被轻松检测到。该测试的研发旨在简单而快速地识别危险病原体。相关研究在线发表在近期的Angewandte Chemie International Edition。 McMaster大学的研究人员开发的这种新的方法主要检测代谢物，蛋白质或DNA片段的最小痕迹。从本质

感染性疾病如丙型肝炎和世界上最致命的超级病菌—包括难辨梭状芽孢杆菌（C.difficile）和MRSA，可能很快在一种独特的诊断测试中被轻松检测到。该测试的研发旨在简单而快速地识别危险病原体。相关研究在线发表在近期的Angewandte Chemie International Edition。

McMaster大学的研究人员开发的这种新的方法主要检测代谢物，蛋白质或DNA片段的最小痕迹。从本质上说，新的方法可以追踪到任何可以证明感染性疾病存在的化合物，不管是呼吸道或胃肠道。McMaster大学的生物介面研究所主任John Brennan说道：“我们开发的方法可以让我们在前所未有的水平上探测目标，新测试在所有报道过的检测系统中拥有最高的灵敏度—比其他检测系统敏感度高出10000倍。”

使用精细的技术，研究人员开发出一种由DNA和特殊的φ29DNA聚合酶组成的分子仪器，当在一些特殊的分子存在时，比如一些特定疾病标记分子或者标示病毒基因存在的DNA分子，DNA聚合酶就会被激活—出现大规模DNA扩增，扩增出现的信号放大很容易就被检测到。新测试方法的另一个重要优点是该方法不需要复杂的设备，在室温下通常条件即可运行。

本研究的主要研究者Yingfu Li表示：“这个发明为创造未来新诊断检测立下了基础。这个发明也可以被用来检测任何我们感兴趣的东西，比如细菌污染或癌症标记蛋白分子等等。我们的方法可以灵敏地检测所有的这些，而且可以在一个相对较短的时间内完成。”

研究人员目前正在试图将测试移动到纸张表面，创造便携式床边即时检测。这将完全省去实验室仪器，或许将来可以普遍到家庭医疗中。

原始出处：

Dr. Meng Liu1, Wenqing Zhang1, Dr. Qiang Zhang2, Prof. Dr. John D. Brennan2,* andProf. Dr. Yingfu Li1,2,*.Biosensing by Tandem Reactions of Structure Switching, Nucleolytic Digestion, and DNA Amplification of a DNA Assembly†.Angewandte Chemie International Edition.June 26, 2015.

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=105969, encodeId=933d10596999, content=这篇资讯带给我们新知识，启发新思维，不论是科研还是临床工作都有很大的帮助。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Aug 27 22:39:00 CST 2016, time=2016-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779917, encodeId=51761e799176f, content=<a href='/topic/show?id=d8e32515d1' target=_blank style='color:#2F92EE;'>#Angew#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2515, encryptionId=d8e32515d1, topicName=Angew)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Sat Oct 17 21:09:00 CST 2015, time=2015-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33043, encodeId=26cc3304351, content=听着很先进, beContent=null, objectType=article, channel=null, level=null, likeNumber=185, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3e301634976, createdName=1dd90e57m73(暂无匿称), createdTime=Sat Jul 18 17:36:00 CST 2015, time=2015-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1321651, encodeId=12e813216514f, content=<a href='/topic/show?id=64049291048' target=_blank style='color:#2F92EE;'>#超级细菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92910, encryptionId=64049291048, topicName=超级细菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea13490, createdName=xqptu, createdTime=Fri Jul 10 00:09:00 CST 2015, time=2015-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31564, encodeId=889c3156462, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Wed Jul 08 12:10:00 CST 2015, time=2015-07-08, status=1, ipAttribution=)]
    2016-08-27 李东泽

    这篇资讯带给我们新知识，启发新思维，不论是科研还是临床工作都有很大的帮助。。。

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=105969, encodeId=933d10596999, content=这篇资讯带给我们新知识，启发新思维，不论是科研还是临床工作都有很大的帮助。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Aug 27 22:39:00 CST 2016, time=2016-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779917, encodeId=51761e799176f, content=<a href='/topic/show?id=d8e32515d1' target=_blank style='color:#2F92EE;'>#Angew#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2515, encryptionId=d8e32515d1, topicName=Angew)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Sat Oct 17 21:09:00 CST 2015, time=2015-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33043, encodeId=26cc3304351, content=听着很先进, beContent=null, objectType=article, channel=null, level=null, likeNumber=185, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3e301634976, createdName=1dd90e57m73(暂无匿称), createdTime=Sat Jul 18 17:36:00 CST 2015, time=2015-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1321651, encodeId=12e813216514f, content=<a href='/topic/show?id=64049291048' target=_blank style='color:#2F92EE;'>#超级细菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92910, encryptionId=64049291048, topicName=超级细菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea13490, createdName=xqptu, createdTime=Fri Jul 10 00:09:00 CST 2015, time=2015-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31564, encodeId=889c3156462, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Wed Jul 08 12:10:00 CST 2015, time=2015-07-08, status=1, ipAttribution=)]
    2015-10-17 cy0324

    #Angew#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=105969, encodeId=933d10596999, content=这篇资讯带给我们新知识，启发新思维，不论是科研还是临床工作都有很大的帮助。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Aug 27 22:39:00 CST 2016, time=2016-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779917, encodeId=51761e799176f, content=<a href='/topic/show?id=d8e32515d1' target=_blank style='color:#2F92EE;'>#Angew#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2515, encryptionId=d8e32515d1, topicName=Angew)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Sat Oct 17 21:09:00 CST 2015, time=2015-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33043, encodeId=26cc3304351, content=听着很先进, beContent=null, objectType=article, channel=null, level=null, likeNumber=185, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3e301634976, createdName=1dd90e57m73(暂无匿称), createdTime=Sat Jul 18 17:36:00 CST 2015, time=2015-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1321651, encodeId=12e813216514f, content=<a href='/topic/show?id=64049291048' target=_blank style='color:#2F92EE;'>#超级细菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92910, encryptionId=64049291048, topicName=超级细菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea13490, createdName=xqptu, createdTime=Fri Jul 10 00:09:00 CST 2015, time=2015-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31564, encodeId=889c3156462, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Wed Jul 08 12:10:00 CST 2015, time=2015-07-08, status=1, ipAttribution=)]
    2015-07-18 1dd90e57m73(暂无匿称)

    听着很先进

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=105969, encodeId=933d10596999, content=这篇资讯带给我们新知识，启发新思维，不论是科研还是临床工作都有很大的帮助。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Aug 27 22:39:00 CST 2016, time=2016-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779917, encodeId=51761e799176f, content=<a href='/topic/show?id=d8e32515d1' target=_blank style='color:#2F92EE;'>#Angew#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2515, encryptionId=d8e32515d1, topicName=Angew)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Sat Oct 17 21:09:00 CST 2015, time=2015-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33043, encodeId=26cc3304351, content=听着很先进, beContent=null, objectType=article, channel=null, level=null, likeNumber=185, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3e301634976, createdName=1dd90e57m73(暂无匿称), createdTime=Sat Jul 18 17:36:00 CST 2015, time=2015-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1321651, encodeId=12e813216514f, content=<a href='/topic/show?id=64049291048' target=_blank style='color:#2F92EE;'>#超级细菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92910, encryptionId=64049291048, topicName=超级细菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea13490, createdName=xqptu, createdTime=Fri Jul 10 00:09:00 CST 2015, time=2015-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31564, encodeId=889c3156462, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Wed Jul 08 12:10:00 CST 2015, time=2015-07-08, status=1, ipAttribution=)]
    2015-07-10 xqptu

    #超级细菌#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=105969, encodeId=933d10596999, content=这篇资讯带给我们新知识，启发新思维，不论是科研还是临床工作都有很大的帮助。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Aug 27 22:39:00 CST 2016, time=2016-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779917, encodeId=51761e799176f, content=<a href='/topic/show?id=d8e32515d1' target=_blank style='color:#2F92EE;'>#Angew#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2515, encryptionId=d8e32515d1, topicName=Angew)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Sat Oct 17 21:09:00 CST 2015, time=2015-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33043, encodeId=26cc3304351, content=听着很先进, beContent=null, objectType=article, channel=null, level=null, likeNumber=185, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3e301634976, createdName=1dd90e57m73(暂无匿称), createdTime=Sat Jul 18 17:36:00 CST 2015, time=2015-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1321651, encodeId=12e813216514f, content=<a href='/topic/show?id=64049291048' target=_blank style='color:#2F92EE;'>#超级细菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92910, encryptionId=64049291048, topicName=超级细菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea13490, createdName=xqptu, createdTime=Fri Jul 10 00:09:00 CST 2015, time=2015-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31564, encodeId=889c3156462, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Wed Jul 08 12:10:00 CST 2015, time=2015-07-08, status=1, ipAttribution=)]
    2015-07-08 huaxipanxing

    看看

    0

Baidu
map
Baidu
map
Baidu
map