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JAHA:幽门螺杆菌感染与颈动脉内膜和中膜增厚相关

2022-01-24 MedSci原创 MedSci原创

幽门螺杆菌感染与颈动脉内膜中层厚度增加相关。因此,幽门螺杆菌感染可能间接促进了大血管事件的发生发展。

全世界感染幽门螺杆菌(H.pylori)多达44亿人。几项研究表明,这种病原体会影响消化系统,导致多种严重的疾病,甚至导致胃肠外疾病,如血管疾病。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员旨在评估幽门螺杆菌感染与颈动脉内膜中层厚度之间的关系。

研究人员检索了电子数据库(MEDLINE、Embase、CENTRAL、Web of Science和Scopus),并确定了截至2020年10月20日的感染和未感染幽门螺杆菌的个体颈动脉内膜中层厚度。研究人员对加权平均差模型与相应的95%CI进行随机效应荟萃分析。该方案已提前在PROSPERO(国际系统评价前瞻性登记中心;CRD42021224485)中注册。

研究人员发现13项研究符合该系统评价和荟萃分析的纳入标准,它们提供了考虑到幽门螺杆菌感染的颈动脉内膜中层厚度的数据。该研究总共纳入了2298名个人的数据(1360人幽门螺杆菌阳性,938人幽门螺杆菌阴性)。与未感染的参与者相比,感染患者的总颈动脉内膜中层厚度明显更大(加权平均差为0.07mm;95%CI为0.02-0.12;P=0.004;I2=91.1%;P<0.001)。在病例右侧颈总动脉发现内膜中层增厚也很显著(加权平均差为0.08mm;95%CI为0.02-0.13,P=0.007;I2=85.1%;P<0.001),而左侧颈总动脉无显著性意义(加权平均差为0.12mm;95%CI为-0.05至0.28,P=0.176;I2=97.4%;P<0.001)。

由此可见,幽门螺杆菌感染与颈动脉内膜中层厚度增加相关。因此,幽门螺杆菌感染可能间接促进了大血管事件的发生发展。

原始出处:

Orsolya Anna Simon.et al.Helicobacter pylori Infection Is Associated With Carotid Intima and Media Thickening: A Systematic Review and Meta‐Analysis.JAHA.2022.https://www.ahajournals.org/doi/10.1161/JAHA.121.022919

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    2022-09-14 kcb069
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    2022-05-02 戴小舞

    本来就影响消化,现在都影响心血管了,危险了!

    0

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    2022-01-23 zhaohui6731
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