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IBD:炎症性肠病的疾病活动与动脉血管疾病的发病率增加有关

2021-05-04 MedSci原创 MedSci原创

尽管炎症性肠病(IBD)主要影响患者的肠道,但是作为一种全身性疾病也会影响身体的其他器官,包括静脉血栓栓塞症(VTE),葡萄膜炎和脓皮病坏疽等。

      尽管炎症性肠病(IBD)主要影响患者的肠道,但是作为一种全身性疾病也会影响身体的其他器官,包括静脉血栓栓塞症(VTE),葡萄膜炎和脓皮病坏疽等。另外,有充分的证据表明其他炎症类免疫疾病如类风湿关节炎,牛皮癣和慢性疾病阻塞性肺疾病(COPD)均会增加患血管疾病的风险。那么对于炎症性肠病这是否成立仍存在争议,因此,本项研究旨在评估这种风险,并针对常规血管危险因素和IBD疾病活动的影响进行进一步的相关性分析。

 

      研究人员对来自英国临床实践研究数据链的患者临床资料进行了队列研究,提取了1997年至2017年患有IBD和匹配对照的受试者的记录。然后进行了Cox比例风险和自控病例系列分析,以检查IBD,疾病活动性和住院与心肌梗塞,中风和心肌梗死的风险之间的关系。

 

       本项研究共纳入了31175例IBD患者(16779例UC,10721例克罗恩病和3675例无法分类的病例)和154412例匹配的对照组患者。在IBD病例中观察到523例心肌梗塞,555例中风和469例心血管死亡事件的发生。Cox回归模型(针对潜在的混杂因素进行了调整)显示,总体而言,IBD患者的血管事件没有明显增加。然而,卧床IBD患者的急性疾病(HR,1.83 [1.28–2.62])和慢性疾病活动(HR,1.69 [1.24–2.30])的危险增加。疾病活动性对于心血管事件的发生的促进作用得到了证实。

图:炎症性肠病对于心血管事件的影响

       尽管本项研究没有发现IBD患者总体上发生血管事件过多的证据,但是研究人员发现活动性疾病对于心血管事件风险增加的现象,因此,抗炎治疗有可能降低心血管疾病的发生风险。

 

 

原始出处:

Timothy R Card. Et al. Disease Activity in Inflammatory Bowel Disease Is Associated With Arterial Vascular Disease. Inflammatory Bowel Diseases.2021.

 

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authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKOmbrYfBTw5jNiaNhiaaQZG2kCuFn5Y5Ib9iaibD4WibZsI35A8jx3PazUicW7ib4tRMlNjCFaA6S7plkQQ/132, createdBy=a3a45325519, createdName=郝浩森, createdTime=Tue May 04 17:20:21 CST 2021, time=2021-05-04, status=1, ipAttribution=)]
    2021-05-06 bnurmamat
  5. 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  6. 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  7. 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authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKOmbrYfBTw5jNiaNhiaaQZG2kCuFn5Y5Ib9iaibD4WibZsI35A8jx3PazUicW7ib4tRMlNjCFaA6S7plkQQ/132, createdBy=a3a45325519, createdName=郝浩森, createdTime=Tue May 04 17:20:21 CST 2021, time=2021-05-04, status=1, ipAttribution=)]
    2021-05-04 ms7000001430317331

    学习了

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1709026, encodeId=d4061e090263b, content=<a href='/topic/show?id=1502333250f' target=_blank style='color:#2F92EE;'>#动脉血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33325, encryptionId=1502333250f, topicName=动脉血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=048f31575940, createdName=ms9833124466084992, createdTime=Tue Jun 15 14:37:55 CST 2021, time=2021-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1756111, encodeId=c13c1e5611196, content=<a href='/topic/show?id=78e1e06924a' target=_blank style='color:#2F92EE;'>#疾病活动#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70692, encryptionId=78e1e06924a, topicName=疾病活动)], attachment=null, authenticateStatus=null, createdAvatar=null, 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channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Thu May 06 07:37:55 CST 2021, time=2021-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=962678, encodeId=939c9626e8c8, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=05775479226, createdName=ms7000001430317331, createdTime=Tue May 04 20:24:23 CST 2021, time=2021-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=962662, encodeId=2c8f962662d1, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=301b2081510, createdName=Monica zhang, createdTime=Tue May 04 18:52:57 CST 2021, time=2021-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=962659, encodeId=799796265911, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Tue May 04 18:17:43 CST 2021, time=2021-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=962648, encodeId=7b03962648fd, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKOmbrYfBTw5jNiaNhiaaQZG2kCuFn5Y5Ib9iaibD4WibZsI35A8jx3PazUicW7ib4tRMlNjCFaA6S7plkQQ/132, createdBy=a3a45325519, createdName=郝浩森, createdTime=Tue May 04 17:20:21 CST 2021, time=2021-05-04, status=1, ipAttribution=)]
    2021-05-04 Monica zhang

    学习了

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1709026, encodeId=d4061e090263b, content=<a href='/topic/show?id=1502333250f' target=_blank style='color:#2F92EE;'>#动脉血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33325, encryptionId=1502333250f, topicName=动脉血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=048f31575940, createdName=ms9833124466084992, createdTime=Tue Jun 15 14:37:55 CST 2021, time=2021-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1756111, encodeId=c13c1e5611196, content=<a href='/topic/show?id=78e1e06924a' target=_blank style='color:#2F92EE;'>#疾病活动#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70692, encryptionId=78e1e06924a, topicName=疾病活动)], attachment=null, authenticateStatus=null, createdAvatar=null, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=301b2081510, createdName=Monica zhang, createdTime=Tue May 04 18:52:57 CST 2021, time=2021-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=962659, encodeId=799796265911, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Tue May 04 18:17:43 CST 2021, time=2021-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=962648, encodeId=7b03962648fd, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKOmbrYfBTw5jNiaNhiaaQZG2kCuFn5Y5Ib9iaibD4WibZsI35A8jx3PazUicW7ib4tRMlNjCFaA6S7plkQQ/132, createdBy=a3a45325519, createdName=郝浩森, createdTime=Tue May 04 17:20:21 CST 2021, time=2021-05-04, status=1, ipAttribution=)]
    2021-05-04 医鸣惊人

    认真学习了

    0

  10. 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    2021-05-04 郝浩森

    学习了

    0

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