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Ann Rheum Dis:全肠道病毒组分析揭示了噬菌体与自身免疫性疾病之间的联系

2022-01-11 从医路漫漫 MedSci原创

许多自身免疫性疾病是由复杂的遗传和环境因素及其相互作用引起的。其中自身免疫疾病的遗传因素通过各种研究揭示,例如全基因组关联研究。

背景:许多自身免疫性疾病是由复杂的遗传和环境因素及其相互作用引起的。其中自身免疫疾病的遗传因素通过各种研究揭示,例如全基因组关联研究。肠道微生物群,指的是定居在我们肠道内的微生物群落,通过免疫和代谢系统对我们的健康产生重大影响。随着分析方法的进步,许多研究揭示了肠道微生物群与人类疾病如代谢性疾病、癌症、肠道疾病之间的复杂关系。至于自身免疫疾病,肠道微生物群被认为是其发展过程中最重要的贡献者之一。

目的:既往已经深入的研究了自身免疫性疾病与肠道微生物群的关系,并确定了几种与自身免疫相关的细菌类群。然而,对肠道病毒在自身免疫性疾病中的作用知之甚少。

方法:在此,我们对476名日本人进行了全肠道病毒体测序分析,这些日本人包括类风湿性关节炎患者、系统性红斑狼疮患者、多发性硬化患者和健康对照受试者。

结果:我们对病毒丰度的病例对照比较显示,在自身免疫性疾病患者,特别是类风湿性关节炎(RA)和系统性红斑狼疮(SLE)患者的肠道中,作为健康肠道病毒主要成分之一的crAss样噬菌体显著减少。此外,SLE患者肠道中的Podoviridae明显减少。为了了解这些病毒是如何影响细菌体的,我们进行了定量的病毒-细菌关联分析,并进行了病毒-细菌相互作用分析。结果显示,Podoviridae和Faecalibacterium丰度之间存在正相关,基于CRISPR的病毒-细菌相互作用分析提供了噬菌体感染的直接证据。拟杆菌门(Bacteroidetes)和厚壁菌门(Firmicutes),包括Ruminococcus spp,检测为crAss样噬菌体的宿主,这些噬菌体在多个样本中复制。

结论:我们的数据表明肠道病毒可以直接或通过细菌影响我们的身体。我们的分析阐明了先前缺失的与自身免疫相关的肠道微生物群,并提出了有助于自身免疫疾病发展的新候选基因。

原文出处: Tomofuji Y,  Kishikawa T,  Maeda Y,et al.Whole gut virome analysis of 476 Japanese revealed a link between phage and autoimmune disease.Ann Rheum Dis 2021 Dec 08

 

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