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J Psychoactive Drugs:神奇蘑菇真是神奇!治疗精神类疾病效果确实是好

2017-07-11 中国生物技术网 中国生物技术网

神奇蘑菇含有作用于精神的成分,一项发表在《精神作用药物期刊》上的综述将这种成分用于治疗的研究得出如下结论:神奇蘑菇不但可以安全有效地治疗焦虑、抑郁、上瘾等疾病,而且比现有的很多治疗方法效果还要更好。

神奇蘑菇含有作用于精神的成分,一项发表在《精神作用药物期刊》上的综述将这种成分用于治疗的研究得出如下结论:神奇蘑菇不但可以安全有效地治疗焦虑、抑郁、上瘾等疾病,而且比现有的很多治疗方法效果还要更好。

这些发现表明,进一步探究裸盖菇素(Psilocybin)这种迷幻剂成分的作用,发现它能够显着改善受精神疾病影响的患者的生活。

麦角酸酰二乙氨(一种迷幻药,略作 LSD,等于lysergide)和裸盖菇素(Psilocybin)等迷幻剂常常被人们认为是一种派对药物,而不被认为是治疗药物。

它们与血清素等神经传导物质具有相似性,还会影响感知能力,干扰意识状态,使得它们可以被用于治疗多种精神疾病。

研究发现,在支持性疗程期间服用少量裸盖菇素可以使严重抑郁症患者的病情得到改善,因为他们的大脑中过去失去联系的部分又重新加强了联系。

这些结果引起了人们的注意,表明使用血清素激动剂(比如裸盖菇素)抑制大脑中有问题的网络同时生成更多具有功能网络的潜力。

加利福尼亚研究人员的这篇综述表明,此类研究是有意义的,接下来将做进一步测试。

他们分析了过去10年中的7个临床试验,这些试验测试了裸盖菇素辅助治疗焦虑、抑郁、成瘾、强迫性等疾病的效果。

加利福尼亚杜鲁大学的研究人员Kelan Thomas说:“对于多种不同的患者群体,裸盖菇素辅助治疗在很多研究中都很安全。”

根据已经认可的精神病治疗评定量表,相比于其他形式的治疗,裸盖菇素效果更好,表明它可以作为很多患者的选择,尤其是那些对其他疗法或药物没有反应的患者。

研究人员写道:“相比于其他基于疗程的治疗方法,裸盖菇素辅助疗法只需要很少的剂量,而且效果持续的时间更长。”

但这并不代表裸盖菇素独立地作为一种药物仍然具有这种好处,由于伦理道德的原因,对精神类药物的疗效的研究并不充分,但这也同时表明没有强力的证据支持下使用裸盖菇素。

现在,我们有充足的理由利用更有力的统计工具进行更大规模的试验,争取获得美国食品药品监督局的批准。

Thomas说:“在综述中总结的临床试验是第二阶段研究,目标是研究安全性和有效性,但其中一些研究是非盲的,且缺少分析。”

第三阶段试验将评估这种药物作为真正治疗手段的有效性和相对价值,使其能够早日成为精神疾病患者的选择。

对裸盖菇素等药物进行如此严重的测试的目的在于,改变人们在过去几十年中一直认为这些药物是非法且有害的观点。

3,4-亚甲二氧基甲基苯丙胺(MDMA)是摇头丸(ecstasy)中的一种活性成分,自从上世纪80年代,它常常被用于歌舞厅。

也有研究表明MDMA在治疗一些精神疾病方法的效果,比如自闭症谱系和创伤后压力等,但是与裸盖菇素类似,在能够将其应用于药物之前,还需要多年的测试来改变人们的偏见。

改变对大麻的态度和法律,使其可以被用于医疗目的,或许能够为其他的精神类物质打开一扇门。

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  1. [GetPortalCommentsPageByObjectIdResponse(id=2098402, encodeId=479620984026a, content=在神奇<a href='/topic/show?id=5f2288493b1' target=_blank style='color:#2F92EE;'>#蘑菇#</a>中发现的一种<a href='/topic/show?id=7a27104988d3' target=_blank style='color:#2F92EE;'>#致幻#</a>化合物——裸盖菇素或许能帮助重新设定大脑中同<a href='/topic/show?id=91cf549e3f1' target=_blank style='color:#2F92EE;'>#抑郁症#</a>相关的神经回路的活动。<a href='/topic/show?id=02ab1480308' target=_blank style='color:#2F92EE;'>#Psilocybin#</a><a href='/topic/show?id=057690433f4' target=_blank style='color:#2F92EE;'>#裸盖菇素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88493, encryptionId=5f2288493b1, topicName=蘑菇), TopicDto(id=104988, encryptionId=7a27104988d3, topicName=致幻), TopicDto(id=54973, encryptionId=91cf549e3f1, topicName=抑郁症), TopicDto(id=14803, encryptionId=02ab1480308, topicName=Psilocybin), TopicDto(id=90433, encryptionId=057690433f4, topicName=裸盖菇素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Fri Nov 04 03:20:16 CST 2022, time=2022-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1784755, encodeId=98211e847552d, content=<a href='/topic/show?id=e451626993' target=_blank style='color:#2F92EE;'>#drugs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6269, encryptionId=e451626993, topicName=drugs)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dcaa509, createdName=tsing_hit, createdTime=Thu Oct 05 18:08:00 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1862257, encodeId=5140186225e59, content=<a href='/topic/show?id=1f0e626267' target=_blank style='color:#2F92EE;'>#Drug#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6262, encryptionId=1f0e626267, topicName=Drug)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Tue Oct 03 08:08:00 CST 2017, time=2017-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1778998, encodeId=ecdf1e78998d1, content=<a href='/topic/show?id=8f881906ca' target=_blank style='color:#2F92EE;'>#active#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1906, encryptionId=8f881906ca, topicName=active)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ba8129, createdName=zhzhxiang, createdTime=Sat Jan 06 18:08:00 CST 2018, time=2018-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570505, encodeId=82cb15e0505c8, content=<a href='/topic/show?id=5f2288493b1' target=_blank style='color:#2F92EE;'>#蘑菇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88493, encryptionId=5f2288493b1, topicName=蘑菇)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=efbb15667433, createdName=楚秀娟, createdTime=Thu Jul 13 04:08:00 CST 2017, time=2017-07-13, status=1, ipAttribution=)]
    2022-11-04 lifestar

    在神奇#蘑菇#中发现的一种#致幻#化合物——裸盖菇素或许能帮助重新设定大脑中同#抑郁症#相关的神经回路的活动。#Psilocybin##裸盖菇素#

    0

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    2017-10-05 tsing_hit
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    2017-10-03 爆笑小医
  4. [GetPortalCommentsPageByObjectIdResponse(id=2098402, encodeId=479620984026a, content=在神奇<a href='/topic/show?id=5f2288493b1' target=_blank style='color:#2F92EE;'>#蘑菇#</a>中发现的一种<a href='/topic/show?id=7a27104988d3' target=_blank style='color:#2F92EE;'>#致幻#</a>化合物——裸盖菇素或许能帮助重新设定大脑中同<a href='/topic/show?id=91cf549e3f1' target=_blank style='color:#2F92EE;'>#抑郁症#</a>相关的神经回路的活动。<a href='/topic/show?id=02ab1480308' target=_blank style='color:#2F92EE;'>#Psilocybin#</a><a href='/topic/show?id=057690433f4' target=_blank style='color:#2F92EE;'>#裸盖菇素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88493, encryptionId=5f2288493b1, topicName=蘑菇), TopicDto(id=104988, encryptionId=7a27104988d3, topicName=致幻), TopicDto(id=54973, encryptionId=91cf549e3f1, topicName=抑郁症), TopicDto(id=14803, encryptionId=02ab1480308, topicName=Psilocybin), TopicDto(id=90433, encryptionId=057690433f4, topicName=裸盖菇素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Fri Nov 04 03:20:16 CST 2022, time=2022-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1784755, encodeId=98211e847552d, content=<a href='/topic/show?id=e451626993' target=_blank style='color:#2F92EE;'>#drugs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6269, encryptionId=e451626993, topicName=drugs)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dcaa509, createdName=tsing_hit, createdTime=Thu Oct 05 18:08:00 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1862257, encodeId=5140186225e59, content=<a href='/topic/show?id=1f0e626267' target=_blank style='color:#2F92EE;'>#Drug#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6262, encryptionId=1f0e626267, topicName=Drug)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Tue Oct 03 08:08:00 CST 2017, time=2017-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1778998, encodeId=ecdf1e78998d1, content=<a href='/topic/show?id=8f881906ca' target=_blank style='color:#2F92EE;'>#active#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1906, encryptionId=8f881906ca, topicName=active)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ba8129, createdName=zhzhxiang, createdTime=Sat Jan 06 18:08:00 CST 2018, time=2018-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570505, encodeId=82cb15e0505c8, content=<a href='/topic/show?id=5f2288493b1' target=_blank style='color:#2F92EE;'>#蘑菇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88493, encryptionId=5f2288493b1, topicName=蘑菇)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=efbb15667433, createdName=楚秀娟, createdTime=Thu Jul 13 04:08:00 CST 2017, time=2017-07-13, status=1, ipAttribution=)]
    2018-01-06 zhzhxiang
  5. [GetPortalCommentsPageByObjectIdResponse(id=2098402, encodeId=479620984026a, content=在神奇<a href='/topic/show?id=5f2288493b1' target=_blank style='color:#2F92EE;'>#蘑菇#</a>中发现的一种<a href='/topic/show?id=7a27104988d3' target=_blank style='color:#2F92EE;'>#致幻#</a>化合物——裸盖菇素或许能帮助重新设定大脑中同<a href='/topic/show?id=91cf549e3f1' target=_blank style='color:#2F92EE;'>#抑郁症#</a>相关的神经回路的活动。<a href='/topic/show?id=02ab1480308' target=_blank style='color:#2F92EE;'>#Psilocybin#</a><a href='/topic/show?id=057690433f4' target=_blank style='color:#2F92EE;'>#裸盖菇素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88493, encryptionId=5f2288493b1, topicName=蘑菇), TopicDto(id=104988, encryptionId=7a27104988d3, topicName=致幻), TopicDto(id=54973, encryptionId=91cf549e3f1, topicName=抑郁症), TopicDto(id=14803, encryptionId=02ab1480308, topicName=Psilocybin), TopicDto(id=90433, encryptionId=057690433f4, topicName=裸盖菇素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Fri Nov 04 03:20:16 CST 2022, time=2022-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1784755, encodeId=98211e847552d, content=<a href='/topic/show?id=e451626993' target=_blank style='color:#2F92EE;'>#drugs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6269, encryptionId=e451626993, topicName=drugs)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dcaa509, createdName=tsing_hit, createdTime=Thu Oct 05 18:08:00 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1862257, encodeId=5140186225e59, content=<a href='/topic/show?id=1f0e626267' target=_blank style='color:#2F92EE;'>#Drug#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6262, encryptionId=1f0e626267, topicName=Drug)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Tue Oct 03 08:08:00 CST 2017, time=2017-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1778998, encodeId=ecdf1e78998d1, content=<a href='/topic/show?id=8f881906ca' target=_blank style='color:#2F92EE;'>#active#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1906, encryptionId=8f881906ca, topicName=active)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ba8129, createdName=zhzhxiang, createdTime=Sat Jan 06 18:08:00 CST 2018, time=2018-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570505, encodeId=82cb15e0505c8, content=<a href='/topic/show?id=5f2288493b1' target=_blank style='color:#2F92EE;'>#蘑菇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88493, encryptionId=5f2288493b1, topicName=蘑菇)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=efbb15667433, createdName=楚秀娟, createdTime=Thu Jul 13 04:08:00 CST 2017, time=2017-07-13, status=1, ipAttribution=)]
    2017-07-13 楚秀娟
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