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NEJM:埃博拉病毒可在康复者精液与眼睛中存活长达6个月

2015-05-09 MedSci MedSci原创

一个国际研究小组最新发现,埃博拉病毒不仅可在康复者精液里长时间存活,还能在康复者的眼睛里存活。研究人员说,这一发现凸显了对康复者进行眼部检查的必要性。由美国埃默里大学医院领衔的小组在新一期《新英格兰医学杂志》上报告说,43岁的美国医生伊恩·克罗泽去年9月在塞拉利昂工作期间感染病毒,然后被送到埃默里大学医院治疗了40天,在血液和尿液检测都显示其体内已没有埃博拉病毒后出院。但两个月后,他的左眼出现炎症


一个国际研究小组最新发现,埃博拉病毒不仅可在康复者精液里长时间存活,还能在康复者的眼睛里存活。研究人员说,这一发现凸显了对康复者进行眼部检查的必要性。

由美国埃默里大学医院领衔的小组在新一期《新英格兰医学杂志》上报告说,43岁的美国医生伊恩·克罗泽去年9月在塞拉利昂工作期间感染病毒,然后被送到埃默里大学医院治疗了40天,在血液和尿液检测都显示其体内已没有埃博拉病毒后出院。但两个月后,他的左眼出现炎症,眼压增高,视力严重下降,不得不再次就医。

研究人员在从克罗泽眼睛内抽取的液体中查出了埃博拉病毒。但他们强调,克罗泽的眼泪和覆盖在眼球外层的结膜中并没有检测到埃博拉病毒,这说明,与埃博拉康复者日常接触没有传染风险。

在接受治疗后,克罗泽的视力目前已经部分恢复。

对塞拉利昂85名埃博拉康复者的一项调查也发现,有40%的人报告出现某种“眼睛问题”。

研究人员说,这个新发现的意义在于,首先,在给埃博拉康复者做眼部手术时必须采取感染控制措施;其次,需要对埃博拉康复者进行跟踪治疗。

负责研究的埃默里大学助理教授史蒂文·耶在一份声明中说:“埃博拉患者康复后,应跟踪监控其是否出现疼痛、发红、光敏感、视力模糊等眼部症状,这些都是(眼睛炎症)葡萄膜炎的症状。”

埃博拉病毒通过患者的血液、分泌物或其他体液传播。研究人员最近发现,在男性埃博拉感染者康复后,病毒在其精液中还可存活6个月,这比以前认为的存活时间长了约一倍。医学界因此建议,在彻底弄清埃博拉病毒在精液中存活时间之前,男性埃博拉康复者发生性行为,必须每次都使用避孕套。

原始出处:
Varkey JB, Shantha JG, Crozier I, Kraft CS, Lyon GM, Mehta AK, Kumar G, Smith JR, Kainulainen MH, Whitmer S, Ströher U, Uyeki TM, Ribner BS, Yeh S.Persistence of Ebola Virus in Ocular Fluid during Convalescence. N Engl J Med. 2015 May 7. 

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1650336, encodeId=dd331650336bf, content=<a href='/topic/show?id=9e424155935' target=_blank style='color:#2F92EE;'>#埃博拉病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41559, encryptionId=9e424155935, topicName=埃博拉病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=639b24003788, createdName=tcm107hq, createdTime=Tue Aug 25 17:13:00 CST 2015, time=2015-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=24791, encodeId=083d24e911f, content=最好就是6个月内不要那个啥,祸害人间~~, beContent=null, objectType=article, channel=null, level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160515/IMG57380B859AD1F1019.jpg, createdBy=2c5c1621956, createdName=jasonuclear, createdTime=Mon May 25 08:12:00 CST 2015, time=2015-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23466, encodeId=3dbb2346632, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Wed May 13 21:27:00 CST 2015, time=2015-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296443, encodeId=c88512964433c, content=<a href='/topic/show?id=76f941560d7' target=_blank style='color:#2F92EE;'>#埃博拉病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41560, encryptionId=76f941560d7, topicName=埃博拉病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85aa264, createdName=redcrab, createdTime=Mon May 11 11:13:00 CST 2015, time=2015-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296526, encodeId=6cef1296526bd, content=<a href='/topic/show?id=efe0e645817' target=_blank style='color:#2F92EE;'>#精液#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76458, encryptionId=efe0e645817, topicName=精液)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Mon May 11 11:13:00 CST 2015, time=2015-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23084, encodeId=6be9230842e, content=这个病毒太厉害了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=227, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=yydlt, createdTime=Sun May 10 10:53:00 CST 2015, time=2015-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23085, encodeId=25f92308518, content=好牛的发现和治疗!, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=yydlt, createdTime=Sun May 10 10:53:00 CST 2015, time=2015-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23079, encodeId=1655230e9f1, content=6个月,太可怕了, beContent=null, objectType=article, channel=null, level=null, likeNumber=200, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9e0b1603164, createdName=lovejing, createdTime=Sun May 10 09:29:00 CST 2015, time=2015-05-10, status=1, ipAttribution=)]
    2015-05-25 jasonuclear

    最好就是6个月内不要那个啥,祸害人间~~

    0

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    2015-05-13 huaxipanxing

    看看

    0

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1650336, encodeId=dd331650336bf, content=<a href='/topic/show?id=9e424155935' target=_blank style='color:#2F92EE;'>#埃博拉病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41559, encryptionId=9e424155935, topicName=埃博拉病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=639b24003788, createdName=tcm107hq, createdTime=Tue Aug 25 17:13:00 CST 2015, time=2015-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=24791, encodeId=083d24e911f, content=最好就是6个月内不要那个啥,祸害人间~~, beContent=null, objectType=article, channel=null, level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160515/IMG57380B859AD1F1019.jpg, createdBy=2c5c1621956, createdName=jasonuclear, createdTime=Mon May 25 08:12:00 CST 2015, time=2015-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23466, encodeId=3dbb2346632, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Wed May 13 21:27:00 CST 2015, time=2015-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296443, encodeId=c88512964433c, content=<a href='/topic/show?id=76f941560d7' target=_blank style='color:#2F92EE;'>#埃博拉病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41560, encryptionId=76f941560d7, topicName=埃博拉病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85aa264, createdName=redcrab, createdTime=Mon May 11 11:13:00 CST 2015, time=2015-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296526, encodeId=6cef1296526bd, content=<a href='/topic/show?id=efe0e645817' target=_blank style='color:#2F92EE;'>#精液#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76458, encryptionId=efe0e645817, topicName=精液)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Mon May 11 11:13:00 CST 2015, time=2015-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23084, encodeId=6be9230842e, content=这个病毒太厉害了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=227, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=yydlt, createdTime=Sun May 10 10:53:00 CST 2015, time=2015-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23085, encodeId=25f92308518, content=好牛的发现和治疗!, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=yydlt, createdTime=Sun May 10 10:53:00 CST 2015, time=2015-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23079, encodeId=1655230e9f1, content=6个月,太可怕了, beContent=null, objectType=article, channel=null, level=null, likeNumber=200, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9e0b1603164, createdName=lovejing, createdTime=Sun May 10 09:29:00 CST 2015, time=2015-05-10, status=1, ipAttribution=)]
    2015-05-11 hb2008ye
  6. [GetPortalCommentsPageByObjectIdResponse(id=1650336, encodeId=dd331650336bf, content=<a href='/topic/show?id=9e424155935' target=_blank style='color:#2F92EE;'>#埃博拉病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41559, encryptionId=9e424155935, topicName=埃博拉病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=639b24003788, createdName=tcm107hq, createdTime=Tue Aug 25 17:13:00 CST 2015, time=2015-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=24791, encodeId=083d24e911f, content=最好就是6个月内不要那个啥,祸害人间~~, beContent=null, objectType=article, channel=null, level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160515/IMG57380B859AD1F1019.jpg, createdBy=2c5c1621956, createdName=jasonuclear, createdTime=Mon May 25 08:12:00 CST 2015, time=2015-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23466, encodeId=3dbb2346632, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Wed May 13 21:27:00 CST 2015, time=2015-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296443, encodeId=c88512964433c, content=<a href='/topic/show?id=76f941560d7' target=_blank style='color:#2F92EE;'>#埃博拉病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41560, encryptionId=76f941560d7, topicName=埃博拉病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85aa264, createdName=redcrab, createdTime=Mon May 11 11:13:00 CST 2015, time=2015-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296526, encodeId=6cef1296526bd, content=<a href='/topic/show?id=efe0e645817' target=_blank style='color:#2F92EE;'>#精液#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76458, encryptionId=efe0e645817, topicName=精液)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Mon May 11 11:13:00 CST 2015, time=2015-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23084, encodeId=6be9230842e, content=这个病毒太厉害了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=227, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=yydlt, createdTime=Sun May 10 10:53:00 CST 2015, time=2015-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23085, encodeId=25f92308518, content=好牛的发现和治疗!, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=yydlt, createdTime=Sun May 10 10:53:00 CST 2015, time=2015-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23079, encodeId=1655230e9f1, content=6个月,太可怕了, beContent=null, objectType=article, channel=null, level=null, likeNumber=200, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9e0b1603164, createdName=lovejing, createdTime=Sun May 10 09:29:00 CST 2015, time=2015-05-10, status=1, ipAttribution=)]
    2015-05-10 yydlt

    这个病毒太厉害了!

    0

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    2015-05-10 yydlt

    好牛的发现和治疗!

    0

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    2015-05-10 lovejing

    6个月,太可怕了

    0

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背景 到现在为止,所有测试的埃博拉病毒疫苗都是根据1976年病扎伊尔爆发的毒株,我们的目的是评估一个新的重组腺病毒5型的基于矢量的埃博拉疫苗的2014年流行的糖蛋白菌株安全性和免疫原性表达。 方法我们在中国江苏省泰州县的一个站点做的随机,双盲,安慰剂对照,第一阶段的临床试验。健康成人(年龄18-60岁)依次登记和随机分配(2:1),由计算机生成的随机化块(6的块大小),接受安慰剂,低剂量的腺病毒

Lancet Infect Dis:乌干达埃博拉病毒造成的长期后遗症

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一个赴非抗埃医生生前发给女儿的微信

一个家庭的群由于爸爸在非洲,妈妈在四川,女儿在上海,为了交流方便,女儿专门建了一个家庭微信群他第一次点赞“爸爸,等你平安归来,女儿带你去海钓,好不好?”刚学会用微信的爸爸在下面调皮地点了个赞我们为他点赞今年1月,爸爸在执行援外医疗任务时突发大面积心肌梗塞,经全力抢救无效,不幸逝世,年仅50岁2014年2月以来,西非地区爆发了大规模的埃博拉出血热疫情,中国政府和军队第一时间向西非各国派遣医疗专家

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