Lupus：CD40 T多态性可能与SLE患者某些临床症状呈负相关

关于CD40 G>T（rs4810485）单核苷酸多态性（SNP）与系统性红斑狼疮风险因素的关系的研究仅有一项。针对这一情况，来自波兰波兹南大学医学科学院生物化学与分子生物学的P Piotrowski等人进行了一项研究，研究结果在线发布在2013年3月的《狼疮》（Lupus）杂志上，作者发现，CD40 T多态性可能与SLE患者某些临床症状成负相关。

该研究共招募了261位SLE患者。研究者对波兰人群中SLE患者和对照组的CD40 G>T SNP的频率进行调查。

研究结果如下，SLE患者和健康人群的CD40 G> T基因型和等位基因频率无显著差异。但是，出现关节炎和神经系统症状的患者与不出现上述症状的患者相比，CD40 TT和GT基因型的频率存在统计学差异﹛分别为OR [比值比]=0.2009 (95% CI=0.07547-0.5348, p=0.0004，Pcorr=0.0068) ，OR =0.2876 (95%CI=0.1371-0.6031, p=0.0005，Pcorr=0.0085) ﹜。

研究发现，CD40 T多态性可能与SLE患者某些临床症状呈负相关。
与红斑狼疮相关的拓展阅读：

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Single nucleotide polymorphism of CD40 region and the risk of systemic lupus erythematosus.
Abstract
There is one study on the association of the CD40 G > T (rs4810485) single nucleotide polymorphism (SNP) as a risk factor of systemic lupus erythematosus (SLE). Therefore, we studied the prevalence of the CD40 G > T SNP in patients with SLE (n = 261) and controls (n = 545) in a Polish population. We did not find significant differences between the CD40 G > T genotype and allele frequency in patients with SLE and healthy individuals. However, the frequency of the CD40 TT and GT genotypes was statistically different between patients with arthritis and neurologic manifestations and patients without these symptoms (OR = 0.2009 (95% CI = 0.07547-0.5348, p = 0.0004, p (corr) = 0.0068) and OR = 0.2876 (95% CI = 0.1371-0.6031, p = 0.0005, p (corr) = 0.0085) respectively). Our observations indicate that the CD40 T variant might be negatively associated with some clinical disease manifestations in patients with SLE.