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2019年ACR:Equillium发表有关狼疮性肾炎中CD6-ALCAM途径的新见解

2019-11-07 Allan MedSci原创

Equillium是一家临床阶段的生物技术公司,旨在利用对免疫生物学的深刻理解来开发用于治疗严重自身免疫和炎性疾病的产品,近日宣布,将在2019年美国风湿病学会(ACR)年会上描述CD6-ALCAM途径在狼疮性肾炎中的重要作用。

Equillium是一家临床阶段的生物技术公司,旨在利用对免疫生物学的深刻理解来开发用于治疗严重自身免疫和炎性疾病的产品,近日宣布,将在2019年美国风湿病学会(ACR)年会上描述CD6-ALCAM途径在狼疮性肾炎中的重要作用。

狼疮性肾炎是指系统性红斑狼疮(SLE)合并双肾不同病理类型的免疫性损害,同时伴有明显肾脏损害临床表现的一种疾病。其发病与免疫复合物形成、免疫细胞和细胞因子等免疫异常有关。医学博士Chaim Putterman说:狼疮性肾炎患者的肾脏中CD6-ALCAM信号显著增加,以及在狼疮性肾炎动物模型中CD6阻滞的相应功效,均支持使用itolizumab靶向狼疮性肾炎的治疗潜力


原始出处:

http://www.firstwordpharma.com/node/1679057#axzz64Xy4dOaT

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    2020-04-12 whmdzju
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    2019-12-11 cqlidoudou
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    2019-11-26 amy0550
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    2019-11-09 10518094zz
  6. [GetPortalCommentsPageByObjectIdResponse(id=1675350, encodeId=253a16e535011, content=<a href='/topic/show?id=cb8a400091' target=_blank style='color:#2F92EE;'>#CAM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4000, encryptionId=cb8a400091, topicName=CAM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=16ac27217804, createdName=whmdzju, createdTime=Sun Apr 12 18:02:00 CST 2020, time=2020-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779658, encodeId=8a511e796580e, content=<a href='/topic/show?id=f72a22e2b7' target=_blank style='color:#2F92EE;'>#ALCAM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2272, encryptionId=f72a22e2b7, topicName=ALCAM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=845e216, createdName=cqlidoudou, createdTime=Wed Dec 11 18:02:00 CST 2019, time=2019-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2058320, encodeId=96532058320a9, content=<a href='/topic/show?id=e8254354e7' target=_blank style='color:#2F92EE;'>#CD6#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4354, encryptionId=e8254354e7, topicName=CD6)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=010d202, createdName=amy0550, createdTime=Tue Nov 26 09:02:00 CST 2019, time=2019-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1387369, encodeId=5c21138e3694e, content=<a href='/topic/show?id=8a3a6814425' target=_blank style='color:#2F92EE;'>#狼疮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68144, encryptionId=8a3a6814425, topicName=狼疮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a6e2500005, createdName=sunrural_42825357, createdTime=Sat Nov 09 00:02:00 CST 2019, time=2019-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400448, encodeId=6ade1400448bd, content=<a href='/topic/show?id=e7c018e7af' target=_blank style='color:#2F92EE;'>#ACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1877, encryptionId=e7c018e7af, topicName=ACR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19792261142, createdName=10518094zz, createdTime=Sat Nov 09 00:02:00 CST 2019, time=2019-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532276, encodeId=95f615322e6cb, content=<a href='/topic/show?id=10b5825e4aa' target=_blank style='color:#2F92EE;'>#肾炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82574, encryptionId=10b5825e4aa, topicName=肾炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=84df12331144, createdName=villahu, createdTime=Sat Nov 09 00:02:00 CST 2019, time=2019-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631357, encodeId=daa7163135ec9, content=<a href='/topic/show?id=66e56905c7' target=_blank style='color:#2F92EE;'>#Equillium#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6905, encryptionId=66e56905c7, topicName=Equillium)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Nov 09 00:02:00 CST 2019, time=2019-11-09, status=1, ipAttribution=)]
    2019-11-09 villahu
  7. [GetPortalCommentsPageByObjectIdResponse(id=1675350, encodeId=253a16e535011, content=<a href='/topic/show?id=cb8a400091' target=_blank style='color:#2F92EE;'>#CAM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4000, encryptionId=cb8a400091, topicName=CAM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=16ac27217804, createdName=whmdzju, createdTime=Sun Apr 12 18:02:00 CST 2020, time=2020-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779658, encodeId=8a511e796580e, content=<a href='/topic/show?id=f72a22e2b7' target=_blank style='color:#2F92EE;'>#ALCAM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2272, encryptionId=f72a22e2b7, topicName=ALCAM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=845e216, createdName=cqlidoudou, createdTime=Wed Dec 11 18:02:00 CST 2019, time=2019-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2058320, encodeId=96532058320a9, content=<a href='/topic/show?id=e8254354e7' target=_blank style='color:#2F92EE;'>#CD6#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4354, encryptionId=e8254354e7, topicName=CD6)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=010d202, createdName=amy0550, createdTime=Tue Nov 26 09:02:00 CST 2019, time=2019-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1387369, encodeId=5c21138e3694e, content=<a href='/topic/show?id=8a3a6814425' target=_blank style='color:#2F92EE;'>#狼疮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68144, encryptionId=8a3a6814425, topicName=狼疮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a6e2500005, createdName=sunrural_42825357, createdTime=Sat Nov 09 00:02:00 CST 2019, time=2019-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400448, encodeId=6ade1400448bd, content=<a href='/topic/show?id=e7c018e7af' target=_blank style='color:#2F92EE;'>#ACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1877, encryptionId=e7c018e7af, topicName=ACR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19792261142, createdName=10518094zz, createdTime=Sat Nov 09 00:02:00 CST 2019, time=2019-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532276, encodeId=95f615322e6cb, content=<a href='/topic/show?id=10b5825e4aa' target=_blank style='color:#2F92EE;'>#肾炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82574, encryptionId=10b5825e4aa, topicName=肾炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=84df12331144, createdName=villahu, createdTime=Sat Nov 09 00:02:00 CST 2019, time=2019-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631357, encodeId=daa7163135ec9, content=<a href='/topic/show?id=66e56905c7' target=_blank style='color:#2F92EE;'>#Equillium#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6905, encryptionId=66e56905c7, topicName=Equillium)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Nov 09 00:02:00 CST 2019, time=2019-11-09, status=1, ipAttribution=)]
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