新型工程化蛋白或可扼杀阿尔兹海默氏症

2015-10-26 佚名生物谷

图片来源：medicalxpress.com 最近，一项来自瑞典皇家理工学院(kth royal institute of technology)的最新研究指出，一种工程化的新型蛋白可以成功抑制携带人类阿尔兹海默氏症基因的小鼠患痴呆症，相关研究或为开发治疗相关疾病的疗法提供希望。文章中研究者开发了一种可以靶向作用淀粉样β蛋白多肽的结合性蛋白，淀粉样β蛋白和阿尔兹海默氏症发病直接相关。当同

图片来源：medicalxpress.com

最近，一项来自瑞典皇家理工学院(kth royal institute of technology)的最新研究指出，一种工程化的新型蛋白可以成功抑制携带人类阿尔兹海默氏症基因的小鼠患痴呆症，相关研究或为开发治疗相关疾病的疗法提供希望。文章中研究者开发了一种可以靶向作用淀粉样β蛋白多肽的结合性蛋白，淀粉样β蛋白和阿尔兹海默氏症发病直接相关。

当同这种结合性蛋白进行组装时，研究者就发现，携带人类阿尔兹海默氏症基因的实验室小鼠就不会患上疾病相关的记忆损伤或认知能力损伤等；这种结合性蛋白同样也可以抑制实验室小鼠大脑中淀粉样蛋白斑块的形成，研究者Lindberg教授指出，我们很高兴可以看到小鼠大脑中淀粉样β蛋白的水平明显下降了。

这种新型结合性蛋白可以模拟抗体的功能但其比抗体要小很多，研究者利用一种名为affibodies的工程化蛋白开发了新型的结合性蛋白，其可以同多种不同致病性的蛋白进行紧密特殊地结合。本文研究中研究者则利用新型蛋白同和阿尔兹海默氏症发病的淀粉样多肽蛋白进行了特殊结合；接受affibodies工程化蛋白治疗的小鼠的表现同健康动物一样。

研究者表示，相关研究结果为开发抵御阿尔兹海默氏症的新型疗法提供了一定思路，同时研究者或许也可以在10年内开发出可用的药物来帮助患者抵御痴呆症等老年性疾病的发生。如今阿尔兹海默氏症是一种常见的痴呆症，针对症状有很多药物进行治疗但并没有有效的根治疗法，因为当前的药物并不能有效针对引发疾病的机制进行作用。

据阿尔茨海默氏症协会数据显示，当前有3500万阿尔兹海默氏症患者，而且研究者估计到2050年这一数字将会翻三倍，随着疾病发展患者的大脑功能会不断下降，最终脑细胞会不断死亡，研究者Stani表示，本文研究中我们开发了一种新型的蛋白质，这种蛋白质具有抑制机体患阿尔兹海默氏症的潜力，因此我们希望通过后期的研究以此为基础来开发真正有效的疗法来帮助遏制该疾病的发生。

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2015-10-28 habb

#阿尔兹海默#

95 0
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2015-10-27 fengzhigu

是啊

229 0
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2015-10-27 liusanxin

看起来不错，实际上……

159 0
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2015-10-26 lixh1719

谨慎的乐观

206 0

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