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Neurology:尿酸盐水平或预示男性患帕金森病风险

2016-01-14 QQduhp 译 MedSci原创

帕金森病是一种运动系统障碍的疾病,主要由于分泌多巴胺的脑细胞减少,通常发生于60岁以上的老人。主要症状有震颤或颤抖、四肢和身体僵硬、运动迟缓、平衡和协调能力受损。症状开始较轻微,随着时间的推移,病情逐渐恶化,进而无法自理。 目前还没有治愈该病的药物,但医务人员采用补充多巴胺的治疗方案,以缓解老人的病情。尿酸是一种强大的抗氧化剂,可消除血液中约60%的自由基。尿酸是嘌呤代谢的终产物。既往研究表明,它

帕金森病是一种运动系统障碍疾病,主要由于分泌多巴胺的脑细胞的减少引起,通常发生于60岁以上的老人中。主要症状有震颤或颤抖、四肢和身体僵硬、运动迟缓、平衡和协调能力受损。症状开始较轻微,随着时间的推移,病情逐渐恶化,进而无法自理。
 
目前还没有治愈该病的药物,但医务人员采用补充多巴胺的治疗方案,以缓解老人的病情。

尿酸是一种强大的抗氧化剂,可消除血液中约60%的自由基。尿酸是嘌呤代谢的终产物。既往研究表明,它可能对大脑细胞起到保护作用。 
宾夕法尼亚州立大学Xiang Gao博士和他的同事对90214名参与者进行了探究。 

研究人员通过采用血液测试来评估参与者的尿酸盐水平。其中共有388人发展为帕金森病,与1267名未患帕金森病的民众对比。研究人员还与既往三项研究联合分析。参与者最低尿酸盐含量小于4.9mg/dL,最高水平为6.3-9.0mg/dL。正常水平范围为3.5-7.2mg/dL。 

结果表明,尿酸盐水平最高的男性相比尿酸盐水平最低的男性而言,患帕金森病的风险减少40%。在患有帕金森病的男性中,45名尿酸水平高,58名男性尿酸水平最低;在健康男性中,111名男性尿酸水平最高,107名尿酸水平最低。此外,研究人员调整了其他可能会影响民众帕金森病风险的因素,如年龄、吸烟、咖啡因使用。

Gao博士指出,这些结果表明,尿酸可以预防帕金森病或减缓其在早期的病情进展。这些发现支持提高早期帕金森患者的尿酸盐水平可能减缓这种疾病进展,但是仍需要更进一步的研究。他指出,这项研究并不能证明高水平的尿酸盐可预防帕金森病,只是相比之下,风险较低。

但是研究人员也需考虑到过高水平的尿酸盐会导致肾结石和痛风。此外他们还需要更多的研究来理解尿酸盐和帕金森病之间在性别方面的差异。

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1992512, encodeId=9c0b1992512eb, content=<a href='/topic/show?id=93b14e55789' target=_blank style='color:#2F92EE;'>#尿酸盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47557, encryptionId=93b14e55789, topicName=尿酸盐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cb02500048, createdName=ms6832696159214430, createdTime=Tue May 17 23:47:00 CST 2016, time=2016-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999637, encodeId=4f97199963eb6, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sun Jul 03 15:47:00 CST 2016, time=2016-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73745, encodeId=243ee374570, content=尿酸是人体必需的抗氧化剂 对于代谢正常的人 单纯性高尿酸血症,即不发生通风者,预示其寿命会长。, beContent=null, objectType=article, channel=null, level=null, likeNumber=151, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1391689658, createdName=180****7709(上善若水), createdTime=Fri Mar 25 13:50:00 CST 2016, time=2016-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=64240, encodeId=96126424094, content=以前不知, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c7b1687122, createdName=1de4b7d2m31(暂无匿称), createdTime=Sat Feb 13 21:57:00 CST 2016, time=2016-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59600, encodeId=a0da596002e, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=213, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuK9CDibOwszLoEBg36ZXqzB5NDasNV9GTfFDmBicM1V8hUS4OtTicG3IiaFIKq4wqD23LUxORRJXqjVs/0, createdBy=00e81647535, createdName=I come, createdTime=Tue Jan 26 15:52:00 CST 2016, time=2016-01-26, status=1, ipAttribution=)]
    2016-07-03 yinhl1978
  3. [GetPortalCommentsPageByObjectIdResponse(id=1992512, encodeId=9c0b1992512eb, content=<a href='/topic/show?id=93b14e55789' target=_blank style='color:#2F92EE;'>#尿酸盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47557, encryptionId=93b14e55789, topicName=尿酸盐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cb02500048, createdName=ms6832696159214430, createdTime=Tue May 17 23:47:00 CST 2016, time=2016-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999637, encodeId=4f97199963eb6, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sun Jul 03 15:47:00 CST 2016, time=2016-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73745, encodeId=243ee374570, content=尿酸是人体必需的抗氧化剂 对于代谢正常的人 单纯性高尿酸血症,即不发生通风者,预示其寿命会长。, beContent=null, objectType=article, channel=null, level=null, likeNumber=151, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1391689658, createdName=180****7709(上善若水), createdTime=Fri Mar 25 13:50:00 CST 2016, time=2016-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=64240, encodeId=96126424094, content=以前不知, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c7b1687122, createdName=1de4b7d2m31(暂无匿称), createdTime=Sat Feb 13 21:57:00 CST 2016, time=2016-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59600, encodeId=a0da596002e, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=213, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuK9CDibOwszLoEBg36ZXqzB5NDasNV9GTfFDmBicM1V8hUS4OtTicG3IiaFIKq4wqD23LUxORRJXqjVs/0, createdBy=00e81647535, createdName=I come, createdTime=Tue Jan 26 15:52:00 CST 2016, time=2016-01-26, status=1, ipAttribution=)]
    2016-03-25 180****7709(上善若水)

    尿酸是人体必需的抗氧化剂 对于代谢正常的人 单纯性高尿酸血症,即不发生通风者,预示其寿命会长。

    0

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    2016-02-13 1de4b7d2m31(暂无匿称)

    以前不知

    0

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    2016-01-26 I come

    有意思

    0

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