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Rheumatology (Oxford):产前暴露于抗疟药可降低心源性新生儿狼疮风险

2017-09-25 佚名 环球医学

一项单中心、回顾性、队列研究表明,产前暴露于抗疟药会降低心源性而非非心源性新生儿狼疮风险。目的:最近的研究表明,产前暴露于HCQ会降低心源性新生儿狼疮风险。本研究旨在评估产妇妊娠期摄入抗疟药(AM)是否会降低心源性和非心源性新生儿狼疮风险。方法:本单中心、回顾性、队列研究的入组标准为:1984年1月1日~2013年10月1日出生的连续儿童,其母亲为CTD并且抗Ro和/或抗La抗体阳性。总共筛查了3



一项单中心、回顾性、队列研究表明,产前暴露于抗疟药会降低心源性而非非心源性新生儿狼疮风险。

目的:最近的研究表明,产前暴露于HCQ会降低心源性新生儿狼疮风险。本研究旨在评估产妇妊娠期摄入抗疟药(AM)是否会降低心源性和非心源性新生儿狼疮风险。

方法:本单中心、回顾性、队列研究的入组标准为:1984年1月1日~2013年10月1日出生的连续儿童,其母亲为CTD并且抗Ro和/或抗La抗体阳性。总共筛查了315名个体,纳入了268名参与者。AM暴露的定义为整个妊娠期HCQ或氯喹给药。结局指标为心源性和非心源性新生儿狼疮。进行了概率和贝叶斯分析。研究人员假设,产前AM暴露会降低心源性而非非心源性新生儿狼疮风险。

结果:总共纳入了268名孕妇,73名整个妊娠期AM暴露。99名婴儿发生新生儿狼疮,117名仍未受到影响,52名未发生心源性新生儿狼疮,但是因他们的完全非心源性新生儿狼疮状态未知而不能被列为未受到影响。Logistic回归表明,AM对心源性新生儿狼疮具有保护作用,但是结果无统计学显着性(OR,0.21;P=0.07)。贝叶斯分析表明,实现心源性新生儿狼疮的保护作用(OR<1.0)的概率为显着性(98.7%)。AM对非心源性新生儿狼疮的影响不具显着性(OR,0.78;P=0.21)。

结论:该大型单中心队列研究显示,整个妊娠期暴露于AM与发生心源性而非非心源性新生儿狼疮概率的降低相关。

原始出处:

Julie Barsalou  Edgar Jaeggi  Carl A. Laskin  Patrick Brown  Simon Y. Tian Robert M. Hamilton  Earl D. Silverman.Prenatal exposure to antimalarials decreases the risk of cardiac but not non-cardiac neonatal lupus: a single-centre cohort study.Rheumatology (Oxford) 1 September 2017

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    2017-09-27 qilu_qi
  6. [GetPortalCommentsPageByObjectIdResponse(id=1972856, encodeId=cfe219e2856c3, content=<a href='/topic/show?id=1a911356535' target=_blank style='color:#2F92EE;'>#Oxford#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13565, encryptionId=1a911356535, topicName=Oxford)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/WQ1WyMBGic8d2fKdCe6Cm3vaRh4X8YnlumYndC46iagNCBl9Df8RtoCaQchnFtZldHUctGJjsgsyutUlu8vPq6yQ/132, createdBy=97862500016, createdName=ms3117646317107274, createdTime=Mon Jan 22 08:26:00 CST 2018, time=2018-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951546, encodeId=8dfa1951546d3, content=<a href='/topic/show?id=aeeb5545681' target=_blank style='color:#2F92EE;'>#抗疟药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55456, encryptionId=aeeb5545681, topicName=抗疟药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca20190, createdName=wushaoling, createdTime=Tue Jul 10 11:26:00 CST 2018, time=2018-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2062520, encodeId=8d7020625201d, content=<a href='/topic/show?id=872c15438a4' target=_blank style='color:#2F92EE;'>#Rheumatology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15438, encryptionId=872c15438a4, topicName=Rheumatology)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3307462, createdName=风铃821, createdTime=Fri Apr 27 11:26:00 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1387228, encodeId=aeae138e22831, content=<a href='/topic/show?id=8a3a6814425' target=_blank style='color:#2F92EE;'>#狼疮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68144, encryptionId=8a3a6814425, topicName=狼疮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a6e2500005, createdName=sunrural_42825357, createdTime=Wed Sep 27 06:26:00 CST 2017, time=2017-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502513, encodeId=b6251502513b8, content=<a href='/topic/show?id=ef4b2441971' target=_blank style='color:#2F92EE;'>#产前#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24419, encryptionId=ef4b2441971, topicName=产前)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b49a9545081, createdName=qilu_qi, createdTime=Wed Sep 27 06:26:00 CST 2017, time=2017-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1593453, encodeId=9a09159345365, content=<a href='/topic/show?id=9850510e9a3' target=_blank style='color:#2F92EE;'>#心源性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51079, encryptionId=9850510e9a3, topicName=心源性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=955718147815, createdName=mhm295, createdTime=Wed Sep 27 06:26:00 CST 2017, time=2017-09-27, status=1, ipAttribution=)]
    2017-09-27 mhm295
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