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Arerugi:推荐一种诊断咳嗽变异性哮喘的手段

2018-07-23 MedSci MedSci原创

本研究旨在探究伴有长期或慢性咳嗽的支气管哮喘(BA),咳嗽变异性哮喘(CVA)和过敏性鼻炎(AR)诊断后,通过强制振荡技术(FOT)吸入支气管扩张剂后进行可逆性试验的有效性。研究共纳入了622名患者,咳嗽三周以上,并使用肺活量测定法和FOT对沙丁胺醇进行支气管可逆性测试。然后将其分成5组:BA,BA + AR,CVA,CVA + AR,AR,并检查其肺功能。结果显示,吸入沙丁胺醇后FEV1改善的平

本研究旨在探究伴有长期或慢性咳嗽的支气管哮喘(BA),咳嗽变异性哮喘(CVA)和过敏性鼻炎(AR)诊断后,通过强制振荡技术(FOT)吸入支气管扩张剂后进行可逆性试验的有效性。

研究共纳入了622名患者,咳嗽三周以上,并使用肺活量测定法和FOT对沙丁胺醇进行支气管可逆性测试。然后将其分成5组:BA,BA + AR,CVA,CVA + AR,AR,并检查其肺功能。

结果显示,吸入沙丁胺醇后FEV1改善的平均值有明显差异(p <0.001):BA 465ml(26%),CVA136ml(5.5%),AR 44ml(1.6%)。然而,在CVA中,平均可逆性值并未超过BA的诊断标准:200毫升(12%)。在BA/CVA中使用FOT在5Hz(R5)下改善呼吸阻力为25.7%/24.1%,并且明显高于AR组(p <0.001),即使是伴有 AR, BA+AR, CVA+AR和AR的情况下,结果仍然类似。用R5诊断AR中的CVA的ROC曲线中的AUC值为0.870,并且在R5,R20,R35和Fres中最高。当R5改善的阈值为15%时,灵敏度为74%,特异性为81%。

综上所述,该研究结果表明,使用FOT进行额外的支气管可逆性试验可能特别有助于诊断咳嗽变异性哮喘,其中单独的肺活量测定法的可逆性不足。

原始出处:

Kato K, Tanaka H. USEFULNESS OF THE FORCED OSCILLATION TECHNIQUE IN THE DIAGNOSIS OF COUGHVARIANT ASTHMA WITH PROLONGED OR CHRONIC COUGH. Arerugi. 2018;67(6):759-766. doi: 10.15036/arerugi.67.759.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=2054414, encodeId=29b7205441490, content=<a href='/topic/show?id=c2113980987' target=_blank style='color:#2F92EE;'>#咳嗽变异性哮喘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39809, encryptionId=c2113980987, topicName=咳嗽变异性哮喘)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLc3PoqaNe4QTZ947pojXuchvvmkkJN0wyBBbA3LVX2WDkgiaJ7cswu9yvA4CB0NicjcrCfBY1zRPkA/132, createdBy=b3812500089, createdName=ms6897892027066920, createdTime=Tue Sep 04 04:12:00 CST 2018, time=2018-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=353068, encodeId=37153530681d, content=有原文可以分享一下吗,没有找到呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e59d2486651, createdName=1246d155m86暂无昵称, createdTime=Mon Nov 19 16:08:11 CST 2018, time=2018-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334481, encodeId=1e2a334481e5, content=好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Fri Jul 27 08:17:27 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334067, encodeId=88ad33406eeb, content=推荐一种诊断咳嗽变异性哮喘的手段。, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Jul 25 12:54:24 CST 2018, time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342504, encodeId=589d13425047a, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Wed Jul 25 08:12:00 CST 2018, time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=333633, encodeId=ff64333633de, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Mon Jul 23 18:25:21 CST 2018, time=2018-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=333628, encodeId=1a413336281a, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Mon Jul 23 17:36:25 CST 2018, time=2018-07-23, status=1, ipAttribution=)]
    2018-11-19 1246d155m86暂无昵称

    有原文可以分享一下吗,没有找到呢

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2054414, encodeId=29b7205441490, content=<a href='/topic/show?id=c2113980987' target=_blank style='color:#2F92EE;'>#咳嗽变异性哮喘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39809, encryptionId=c2113980987, topicName=咳嗽变异性哮喘)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLc3PoqaNe4QTZ947pojXuchvvmkkJN0wyBBbA3LVX2WDkgiaJ7cswu9yvA4CB0NicjcrCfBY1zRPkA/132, createdBy=b3812500089, createdName=ms6897892027066920, createdTime=Tue Sep 04 04:12:00 CST 2018, time=2018-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=353068, encodeId=37153530681d, content=有原文可以分享一下吗,没有找到呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e59d2486651, createdName=1246d155m86暂无昵称, createdTime=Mon Nov 19 16:08:11 CST 2018, time=2018-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334481, encodeId=1e2a334481e5, content=好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Fri Jul 27 08:17:27 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334067, encodeId=88ad33406eeb, content=推荐一种诊断咳嗽变异性哮喘的手段。, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Jul 25 12:54:24 CST 2018, time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342504, encodeId=589d13425047a, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Wed Jul 25 08:12:00 CST 2018, time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=333633, encodeId=ff64333633de, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Mon Jul 23 18:25:21 CST 2018, time=2018-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=333628, encodeId=1a413336281a, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Mon Jul 23 17:36:25 CST 2018, time=2018-07-23, status=1, ipAttribution=)]
    2018-07-27 张新亮1853311252142e2fm

    好文章学习了

    0

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    2018-07-25 jyzxjiangqin

    推荐一种诊断咳嗽变异性哮喘的手段。

    0

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  6. [GetPortalCommentsPageByObjectIdResponse(id=2054414, encodeId=29b7205441490, content=<a href='/topic/show?id=c2113980987' target=_blank style='color:#2F92EE;'>#咳嗽变异性哮喘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39809, encryptionId=c2113980987, topicName=咳嗽变异性哮喘)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLc3PoqaNe4QTZ947pojXuchvvmkkJN0wyBBbA3LVX2WDkgiaJ7cswu9yvA4CB0NicjcrCfBY1zRPkA/132, createdBy=b3812500089, createdName=ms6897892027066920, createdTime=Tue Sep 04 04:12:00 CST 2018, time=2018-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=353068, encodeId=37153530681d, content=有原文可以分享一下吗,没有找到呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e59d2486651, createdName=1246d155m86暂无昵称, createdTime=Mon Nov 19 16:08:11 CST 2018, time=2018-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334481, encodeId=1e2a334481e5, content=好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Fri Jul 27 08:17:27 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334067, encodeId=88ad33406eeb, content=推荐一种诊断咳嗽变异性哮喘的手段。, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Jul 25 12:54:24 CST 2018, time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342504, encodeId=589d13425047a, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Wed Jul 25 08:12:00 CST 2018, time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=333633, encodeId=ff64333633de, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Mon Jul 23 18:25:21 CST 2018, time=2018-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=333628, encodeId=1a413336281a, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Mon Jul 23 17:36:25 CST 2018, time=2018-07-23, status=1, ipAttribution=)]
    2018-07-23 天地飞扬

    了解一下,谢谢分享!

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2054414, encodeId=29b7205441490, content=<a href='/topic/show?id=c2113980987' target=_blank style='color:#2F92EE;'>#咳嗽变异性哮喘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39809, encryptionId=c2113980987, topicName=咳嗽变异性哮喘)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLc3PoqaNe4QTZ947pojXuchvvmkkJN0wyBBbA3LVX2WDkgiaJ7cswu9yvA4CB0NicjcrCfBY1zRPkA/132, createdBy=b3812500089, createdName=ms6897892027066920, createdTime=Tue Sep 04 04:12:00 CST 2018, time=2018-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=353068, encodeId=37153530681d, content=有原文可以分享一下吗,没有找到呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e59d2486651, createdName=1246d155m86暂无昵称, createdTime=Mon Nov 19 16:08:11 CST 2018, time=2018-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334481, encodeId=1e2a334481e5, content=好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Fri Jul 27 08:17:27 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334067, encodeId=88ad33406eeb, content=推荐一种诊断咳嗽变异性哮喘的手段。, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Jul 25 12:54:24 CST 2018, time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342504, encodeId=589d13425047a, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Wed Jul 25 08:12:00 CST 2018, time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=333633, encodeId=ff64333633de, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Mon Jul 23 18:25:21 CST 2018, time=2018-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=333628, encodeId=1a413336281a, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Mon Jul 23 17:36:25 CST 2018, time=2018-07-23, status=1, ipAttribution=)]
    2018-07-23 三生有幸9135

    学习一下

    0

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