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Nat Commun:刷新认知!生物钟竟可阻止肝癌进展!

2018-11-11 Michael,Zoe 转化医学网

近日,由来自休斯顿德克萨斯大学健康科学中心(UTHealth)的研究人员发现,体内生物钟竟然对抑制肝癌具有显着作用。他们发现在50%的肝癌组织中会出现一种功能失调的蛋白,而这种蛋白又可诱导机体生物钟功能障碍,该研究的最新进展发表于最新的《Nature Communications》杂志。让我们来看看生物钟与肝癌究竟是如何相互影响的。

请问各位读者有没有经常熬夜?经常黑白颠倒?经常作息时间不规律?如何存在这些生活陋习,那一定要及时纠正了。近日,由来自休斯顿德克萨斯大学健康科学中心(UTHealth)的研究人员发现,体内生物钟竟然对抑制肝癌具有显着作用。他们发现在50%的肝癌组织中会出现一种功能失调的蛋白,而这种蛋白又可诱导机体生物钟功能障碍,该研究的最新进展发表于最新的《Nature Communications》杂志。让我们来看看生物钟与肝癌究竟是如何相互影响的。

首先,我们来认识一下我们身体内的时钟,即生物钟。生物钟是一个生命体本身的24小时计时系统,但它又不仅仅是一个简单的计时器,同时他可以通过多条信号通路参与调控身体所有细胞的正常运转,并调节人体及动物体睡眠,新陈代谢和其他重要的身体功能。

该研究的资深作者,代谢中心助理教授Kristin Eckel-Mahan博士表示“通过在细胞水平操纵动物的生物钟,他们能够在小鼠模型中抑制肝癌的生长”。 Eckel-Mahan教授也表示,其他研究人员在人体组织样本中也证实了他们的发现。



据美国疾病控制与预防中心报告,2015年美国一共报告了32,908例新发肝癌病例,其中25,760人最终死于肝癌。这个数据在所有类型的肿瘤中也属于高致死率的肿瘤。因此,研究和开发新型抗肝癌药物成为当下肿瘤研究一个较为受欢迎的研究热点。

Eckel-Mahan教授的研究小组在肝癌患者的组织内发现了一种功能失常的蛋白质,该蛋白质抑制了关键昼夜节律转录因子的表达,并阻断了肿瘤抑制因子执行其正常24小时的细胞功能。当研究人员迫使肿瘤细胞重新表达这种奇特的蛋白时,肿瘤细胞就会死亡。Eckel-Mahan教授表示,50%的肝脏肿瘤可以表达这种功能失常的蛋白质,并导致这些细胞出现昼夜节律功能障碍,进而导致肿瘤抑制因子失调,最终引起肝癌的不可控性。

研究人员这项研究的重点是肝细胞癌(HCC),这一肿瘤是人类发现的主要肝脏恶性肿瘤之一,也是所有恶性肿瘤致死率排名第二的肿瘤类型。随着肥胖相关性脂肪肝疾病患病人数的与日俱增,肝细胞癌患者也正在随之上升。



Eckel-Mahan教授表示“这些结果表明,针对肝细胞肝癌患者体内的生物钟关键蛋白可能是阻止肝细胞肝癌肿瘤生长和进展潜在的治疗方案。接下来的研究将是明确如何提前预防肿瘤抑制相关性细胞生物钟的紊乱,并研究现有的药物能否改善人体生物钟的正常功能并最终阻止肝癌的进展。

所以说,正常的生物钟对于阻止癌症的进展至关重要。根据这项研究,我们可以反向推理一下,如何因为我们自身生活作息的异常导致身体内的生物钟功能紊乱,那么是不是也会导致抑制性细胞的功能失调呢?所以保持一个健康良好的生活作息习惯才是对自己身体负责。

原始出处:Fekry B, Ribas-Latre A, Baumgartner C, et al. Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma. Nat Commun. 2018 Oct 19;9(1):4349. 

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    2019-10-25 liuli5079
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    2019-02-15 liye789132251
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    2018-11-15 orangesking

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2087457, encodeId=03d0208e45767, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Fri Oct 25 00:08:00 CST 2019, time=2019-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1883418, encodeId=6b6518834184d, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Fri Feb 15 23:08:00 CST 2019, time=2019-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352687, encodeId=af2e35268e55, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Thu Nov 15 19:59:31 CST 2018, time=2018-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352392, encodeId=df0d352392b0, content=学习了,很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/mjoCpRKGsP5icib6bMgxrYQfeS1mCb8mEib8DKvmxUicqrWrf7mtcRmzERic2KGibyoFNr4vheOB9SibjCAX6KS2DGgWw/132, createdBy=5fe92480877, createdName=wsh2709, createdTime=Mon Nov 12 17:25:50 CST 2018, time=2018-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352388, encodeId=cdc03523885f, content=早睡早起!, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuMR3WZ1VnSfbWUadIWeyMyS20yXZARSoSoYng9V8Qjz3mK7SsCiazXVErDamlfgtiaWXjP1nv3I2tX/0, createdBy=94ef2037358, createdName=小太阳馒头, createdTime=Mon Nov 12 16:38:52 CST 2018, time=2018-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352361, encodeId=b10635236185, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Mon Nov 12 09:06:20 CST 2018, time=2018-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352341, encodeId=182535234138, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=91802412712, createdName=1237cdb8m17暂无昵称, createdTime=Mon Nov 12 07:43:04 CST 2018, time=2018-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352338, encodeId=2ee43523382c, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Mon Nov 12 06:52:11 CST 2018, time=2018-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352330, encodeId=e1a0352330f6, content=学习了很有用不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Mon Nov 12 01:47:50 CST 2018, time=2018-11-12, status=1, ipAttribution=)]
    2018-11-12 wsh2709

    学习了,很好

    0

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    2018-11-12 小太阳馒头

    早睡早起!

    0

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    2018-11-12 kafei

    学习了谢谢

    0

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    2018-11-12 1237cdb8m17暂无昵称

    学习了

    0

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    2018-11-12 深海的鱼

    学习学习学习

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    2018-11-12 飛歌

    学习了很有用不错

    0

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