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JCEM:雄性激素增加了女性患子宫肌瘤的风险

2015-12-17 cuiqian译 MedSci原创

根据发表在Journal of Clinical Endocrinology & Metabolism的一项研究,有高水平的睾丸激素和雌激素的中年女性比激素水平较低的女性的子宫可能面临对更大的风险,即子宫肌瘤。斯坦福大学医学院Sc.D,该研究的作者之一, Jason Y.Y. Wong说,四分之三的女性到50岁时会发展为子宫肌瘤。非裔美国女性或超重的女性都面临着发展子宫肌瘤更大的风险。子宫

根据发表在Journal of Clinical Endocrinology & Metabolism的一项研究,有高水平的睾丸激素和雌激素的中年女性比激素水平较低的女性的面临对更大的子宫疾病风险,即子宫肌瘤。

斯坦福大学医学院Sc.D,该研究的作者之一, Jason Y.Y. Wong说,四分之三的女性到50岁时会发展为子宫肌瘤。非裔美国女性或超重的女性发展为子宫肌瘤的风险更大。子宫肌瘤可以导致不规则出血,不孕,盆腔疼痛,复发性流产和其他生殖并发症。第一线治疗是接受子宫切除术,并且目前可用的一些其他的治疗选择较少。

睾酮是性激素中称为雄激素中的一种。虽然睾丸激素通常与男性相关,但女性女性也自然产生少量的激素。

“我们的研究表明,经历绝经过渡期的女性有较高的睾丸激素水平,发生肌瘤的风险增加,特别是如果他们也有更高的雌激素水平,”Wong说。“这项研究是对雄激素和雌激素水平和子宫肌瘤的发展之间的关系的第一个纵向调查。”

这项13年的纵向研究检测了参加全国女性健康研究(SWAN)中的女性激素水平和子宫肌瘤的的发病率之间的关系。在研究开始时共有3240名女性参加,43.6%的参与者完成了后续的访问。在近一年的访问中,参加者进行了血液测试检查雌激素和雄激素水平。此外,这些女性还被问及她们是否曾被诊断患有或接受过子宫肌瘤治疗。

在参与者中,512名女性报告只有一次子宫肌瘤的发病,另有478名女性有复发状况。在血液中有较高水平的睾酮的参与者更容易患子宫肌瘤,是睾丸激素水平低的女性的1.33倍。有高水平的睾丸激素和雌激素女性面临更大的风险。虽然这两种激素水平很高的女性更可能患单发性子宫肌瘤,但她们也不太可能比低激素水平的女性有较高的复发率。

“我们的研究结果是特别有趣的,因为以前没有认识到睾丸激素是子宫肌瘤发展的一个因素,”另一位研究的作者,斯坦福大学医学院和退伍军人在帕洛阿尔托事务Palo Alto医疗保健系统的医学博士,Jennifer S. Lee说。“这项研究开辟了询问有关肌瘤如何发展以及如何治疗的线索。鉴于治疗子宫肌瘤的费用估计为每年$34.4,这项研究的结果对于找出新的方法来更好地治疗这种常见的情况是很重要的。”

原始出处:

Jason Y. Y. Wong, Ellen B. Gold, Wesley O. Johnson,et al.Circulating Sex Hormones and Risk of Uterine Fibroids: Study of Women's Health Across the Nation (SWAN),Journal of Clinical Endocrinology & Metabolism,2015.12.15

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    2016-06-11 achengzhao
  2. [GetPortalCommentsPageByObjectIdResponse(id=2062912, encodeId=251b206291204, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Sat Jun 11 08:47:00 CST 2016, time=2016-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1981681, encodeId=db0a19816818a, content=<a href='/topic/show?id=e4ff986824c' target=_blank style='color:#2F92EE;'>#雄性激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98682, encryptionId=e4ff986824c, topicName=雄性激素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3289320, createdName=海豹, createdTime=Wed May 11 19:47:00 CST 2016, time=2016-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777530, encodeId=03f81e775303d, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Sun Sep 25 01:47:00 CST 2016, time=2016-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48281, encodeId=bda84828137, content=好文章,值得看。, beContent=null, objectType=article, channel=null, level=null, likeNumber=175, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 16:16:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1286358, encodeId=0d9c1286358cc, content=<a href='/topic/show?id=24395268347' target=_blank style='color:#2F92EE;'>#性激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52683, encryptionId=24395268347, topicName=性激素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Sat Dec 19 09:47:00 CST 2015, time=2015-12-19, status=1, ipAttribution=)]
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    2016-09-25 smallant2015
  4. [GetPortalCommentsPageByObjectIdResponse(id=2062912, encodeId=251b206291204, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Sat Jun 11 08:47:00 CST 2016, time=2016-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1981681, encodeId=db0a19816818a, content=<a href='/topic/show?id=e4ff986824c' target=_blank style='color:#2F92EE;'>#雄性激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98682, encryptionId=e4ff986824c, topicName=雄性激素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3289320, createdName=海豹, createdTime=Wed May 11 19:47:00 CST 2016, time=2016-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777530, encodeId=03f81e775303d, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Sun Sep 25 01:47:00 CST 2016, time=2016-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48281, encodeId=bda84828137, content=好文章,值得看。, beContent=null, objectType=article, channel=null, level=null, likeNumber=175, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 16:16:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1286358, encodeId=0d9c1286358cc, content=<a href='/topic/show?id=24395268347' target=_blank style='color:#2F92EE;'>#性激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52683, encryptionId=24395268347, topicName=性激素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Sat Dec 19 09:47:00 CST 2015, time=2015-12-19, status=1, ipAttribution=)]
    2015-12-26 hixiaoluo

    好文章,值得看。

    0

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