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Chest:传统香烟与电子烟对氧化应激和血管功能的影响

2016-10-02 xing.T MedSci原创

由此可见,单次吸食香烟对氧化应激标志物和血流介导的血管扩张程度的就会产生不利影响,尽管电子香烟似乎影响较。但是,吸电子香烟对血管的慢性影响进行进一步的研究是很有必要的。

人们在戒烟过程中,很多人选择通过先用电子烟来替代真正的烟草,达到缓慢的戒烟效果。然而,电子烟的血管安全性尚未澄清。最近,呼吸疾病领域权威杂志《Chest》杂志发表了一篇旨在比较电子烟与传统香烟对健康吸烟者和不吸烟成年人氧化应激和血管内皮功能的影响。

研究者采用交叉、单盲的研究,纳入了40名健康受试者(20吸烟者和20名不吸烟者,两组研究对象年龄和性别相匹配)。首先,所有受试者都吸传统香烟,一个星期后,所有吸香烟者改吸相同尼古丁含量的电子烟。研究对象在吸烟前和吸烟后采集血液样本,并测量氧化应激标志物、一氧化氮的生物利用度、维生素E水平以及血流介导的血管扩张程度。

研究者发现:吸传统香烟和电子烟都可导致可溶性NOX2衍生肽和8-异前列腺素F2α水平显著升高,而一氧化氮的生物利用度、维生素E水平以及血流介导的血管扩张程度显著下降。广义估计方程分析证实,氧化应激标志物和血流介导的血管扩张程度受吸烟的影响显著,而研究结果表明电子香烟与传统香烟对维生素E水平(P=0.413)以及血流介导的血管扩张程度(P=0.311)的生物学效应的影响均无统计学差异。然而,电子香烟似乎比传统香烟对可溶性NOX2衍生肽(P=0.001)、8-异前列腺素F2α(P=0.046)和一氧化氮的生物利用度(P=0.001)的水平影响较小。

由此可见,单次吸食香烟对氧化应激标志物和血流介导的血管扩张程度就会产生不利影响,尽管电子香烟似乎影响较小。但是,吸电子香烟对血管的慢性影响进行进一步的研究很有必要。

原始出处:

Roberto Carnevale. et al. Acute Impact of Tobacco vs Electronic Cigarette Smoking on Oxidative Stress and Vascular Function. Chest. 2016.

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    2017-05-12 Smile2680
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    2016-10-06 忠诚向上

    好好学习

    0

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