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Adv Mater:基于超薄MXene微模型的场效应晶体管用于监测神经系统活动

2017-05-30 佚名 MaterialsViews

大脑作为人类成为万物之灵的重要武器,一直是科学家研究的重要课题。人类在长期的进化发展中,产生了语言和思维,使得人类不仅能够被动地适应外界环境变化,而且能够主动认识世界,改造世界。这一切都要直接或者间接的依靠神经系统的调节和控制。因此,揭示神经元间各种不同的映射形式,了解神经回路的基础对于提高人类神经系统活动的效率和阐明神经系统疾患的病因,机制,探索治疗新手段有重要意义。自从2011年以来,因为其优

大脑作为人类成为万物之灵的重要武器,一直是科学家研究的重要课题。人类在长期的进化发展中,产生了语言和思维,使得人类不仅能够被动地适应外界环境变化,而且能够主动认识世界,改造世界。这一切都要直接或者间接的依靠神经系统的调节和控制。因此,揭示神经元间各种不同的映射形式,了解神经回路的基础对于提高人类神经系统活动的效率和阐明神经系统疾患的病因,机制,探索治疗新手段有重要意义。

自从2011年以来,因为其优良的机械,电学和物理化学性质,被誉为拥有着堪比石墨烯的新兴二维材料MXene获得了越来越多的关注。MXene拥有生物兼容的亲水性表面和金属一样传导电子的能力,同时作为原子层面的二维材料使得其成为生物信号传感的完美候选人。然而目前,MXene在细胞层面进行生物监测和功能表征的应用研究却基本处于空白,这种材料究竟能否胜任生物信号传感检测,及会有怎样的检测表现都仍是未知。

香港城市大学史鹏和支春义课题组首次将新型二维材料应用于神经系统活动的监测。基于微接触印刷技术(microcontact printing)将微米级别MXene图模印制成场效应晶体管电路;同时利用MXene优良的导电性与生物兼容性,实现神经细胞与电极的直接联系,通过电信号的变化监测神经细胞分泌物并进一步探索神经系统活动。研究表明,MXene生物传感器不仅拥有很高的检测灵敏度,而且相比较于传统的高速钙离子成像系统,其检测结果更加方便,快捷和精准。

原始出处:

Bingzhe Xu,Minshen Zhu,Wencong Zhang,et al.Ultrathin MXene-Micropattern-Based Field-Effect Transistor for Probing Neural Activity.Advanced Materials.29 February 2016

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    2017-06-19 天涯183

    非常好的文章,学习了,很受益

    0

  3. 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    2017-06-06 天涯183

    非常好的文章,学习了,很受益

    0

  4. 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  5. 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    2017-06-01 往日如昨

    学习了谢谢分享

    0

  6. 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    2017-05-31 meiliwuxian

    看不懂

    0

  7. 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attachment=null, authenticateStatus=null, createdAvatar=, createdBy=445f1740270, createdName=meiliwuxian, createdTime=Wed May 31 06:41:48 CST 2017, time=2017-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204511, encodeId=652f204511c4, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Tue May 30 23:00:08 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204505, encodeId=f42b2045051f, content=研究表明,MXene生物传感器不仅拥有很高的检测灵敏度,而且相比较于传统的高速钙离子成像系统,其检测结果更加方便,快捷和精准。, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Tue May 30 22:49:17 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204481, encodeId=b0002044812d, content=非常好的文章,学习了,很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Tue May 30 21:29:19 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204477, encodeId=33c42044e799, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/Q3auHgzwzM6P57Bs8gOPaY1cQP9lIia0lmZOEXraGaoicqNToIslXDKw/0, createdBy=7a041951742, createdName=衣带渐宽, createdTime=Tue May 30 21:20:43 CST 2017, time=2017-05-30, status=1, ipAttribution=)]
    2017-05-30 明月清辉

    谢谢分享,学习了

    0

  8. 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objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/Q3auHgzwzM6P57Bs8gOPaY1cQP9lIia0lmZOEXraGaoicqNToIslXDKw/0, createdBy=7a041951742, createdName=衣带渐宽, createdTime=Tue May 30 21:20:43 CST 2017, time=2017-05-30, status=1, ipAttribution=)]
    2017-05-30 有备才能无患

    研究表明,MXene生物传感器不仅拥有很高的检测灵敏度,而且相比较于传统的高速钙离子成像系统,其检测结果更加方便,快捷和精准。

    0

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objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/Q3auHgzwzM6P57Bs8gOPaY1cQP9lIia0lmZOEXraGaoicqNToIslXDKw/0, createdBy=7a041951742, createdName=衣带渐宽, createdTime=Tue May 30 21:20:43 CST 2017, time=2017-05-30, status=1, ipAttribution=)]
    2017-05-30 天涯183

    非常好的文章,学习了,很受益

    0

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    2017-05-30 衣带渐宽

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